N/A N=336 Assessment of Myocardial Ischemic-Reperfusion Injury During Off- and On- Pump CABG
Ischemic Heart Disease · Coronary Artery Disease · Ischemic Reperfusion Injury
Primary: Myeloperoxidase — 184.3; 66.5; 144.71 g/L
Clinical Trial Search
Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
N/A N=59 Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins
Hyperglycemia
Primary: Forearm Blood Flow — 6.48; 9.2; 7.32; 8.26 ml/100 ml tissue/min
Phase 1 N=20 Reperfusion With Cooling in Cerebral Acute Ischemia
Stroke, Acute
Primary: Number of Participants With Reperfusion Injury Hemorrhagic Transformation — 3 participants
N/A N=266 Remote Ischemic Postconditioning in Humans
Myocardial Reperfusion Injury
Primary: Maximum Increase of Troponin at 24 Hours — 0.478; 0.476 ng/ml
Phase 3 N=88 Erythropoietin (EPO) and Ischemia-reperfusion After Kidney Transplantation
Kidney Transplantation
Primary: Kidney Graft Function by Estimated Glomerular Filtration Rate (eGFR) — 47; 46 ml/min — p=<0.05
N/A N=96 Remote Ischemic Preconditioning in ad Hoc Percutaneous Coronary Interventions
Coronary Artery Disease
Primary: Delta Cardiac Troponin I (ΔcTnI) — 0.04; 0.19 ng/mL
Phase 4 N=104 Pilot Study of Edaravone to Treat Acute Myocardial Infarction
Myocardial Infarction · Reperfusion Injury
Primary: Cardiac Death — 0; 0 events
N/A N=30 Remote Ischemic Conditioning to Enhance Resuscitation (RICE) Pilot
Cardiac Arrest
Primary: Attrition — 0; 0 Participants
N/A N=160 The Effect of Remote Ischemic Preconditioning in Living Donor Hepatectomy
Tissue Donors · Liver Transplantation · Ischemia Reperfusion Injury
Primary: Postopera The Maximal Aspartate Aminotransferase Level Within 7 Postoperative Days — 145; 152 IU/L
N/A N=60 Inhibition of Lipid Peroxidation During Cardiac Surgery
Cardiopulmonary Bypass Induced Lipid Peroxidation
Primary: Plasma Isofuran Concentrations — 61.5; 67.7; 72.1; 82.7 pg/mL — p=0.05
Phase 1 N=16 Reoxygenation After Cardiac Arrest II (REOX II Study)
Cardiac Arrest
Primary: Plasma Isofurans (pg/mL)/Isoprostanes (pg/mL) Ratio
N/A N=626 Remote Ischaemic Postconditioning in the Clinical Setting of NSTEACS and Urgent PCI
Post Procedural Myocardial Infarction
Primary: Peri-Procedural Myocardial Injury — 23; 29 Participants
Phase 2 N=103 Phase II Clinical Trial to Evaluate the Benefits of Postconditioning in ST-Elevation Myocardial Infarction (STEMI)
Acute Myocardial Infarction
Primary: Infarct Size on Baseline Cardiac Magnetic Resonance Imaging (cMRI) — 20.1; 21.0 ml — p=0.90
N/A N=18 Renal Perfusion, Filtration and Oxygenation During Cardiopulmonary Bypass (CPB)
Complication of Extracorporeal Circulation · Renal Impairment
Primary: Renal Blood Flow (RBF) — 554; 524; 564; 558 ml per minute per 1.73 m2 body surface — p=0.638
Phase 2 N=30 Sodium Nitrite in Acute Myocardial Infarction
Acute Myocardial Infarction
Primary: Ischemia Area at Risk as Determined by Paired Single-photon Computed Tomography Studies With Technetium Tc99m Sestamibi.
N/A N=101 Remote Ischemic Preconditioning and Contrast Induced - Acute Kidney Injury in Patients Undergoing Elective PCI
Remote Ischemic Preconditioning · Contrast Induced - Acute Kidney Injury
Primary: Number of Participants With Contrast Induced-Acute Kidney Injury — 2; 3 participants
N/A N=96 Effect of Epinephrine/ Phenylephrine for Preventing the Postreperfusion Syndrome During Reperfusion in Liver Transplantation
Hypotension After Reperfusion in Liver Transplantation
Primary: Occurrence of Postreperfusion Syndrome (PRS) — 45; 39; 87 percentage of participants
Phase 2 N=31 REVEAL: Reduction of Infarct Expansion and Ventricular Remodeling With Erythropoietin After Large Myocardial Infarction
Acute ST Elevation Myocardial Infarction
Primary: Infarct Size in the Territory of the Infarct Related Artery — 15.8; 15.0 percentage of LV mass
Phase 2 N=27 The Effects of Intravenous Heme Arginate on Heme Oxygenase-1 Expression (HO-1) and Oxidative Stress in the Human Heart
Myocardial Ischemia
Primary: Heme Oxygenase-1 (HO-1) Messenger Ribonucleic Acid (mRNA) Levels (Atrial Tissue) — 392.7; 229.8; 10.8 arbitrary units — p==0.001
Phase 2 N=9 Reparixin in Pancreatic Islet Transplantation
Pancreatic Islet Transplantation in Type 1 Diabetes Mellitus
Primary: The Percentage of Insulin-independent Patients Following Single Infusion Islet Cell Transplantation at Day 75 +/- 5 — 0; 0 percentage of patients
Phase 2 N=205 Remote Ischemic Preconditioning Prior to Vascular Surgery
Peripheral Arterial Disease · Vascular Surgery
Primary: Troponin I Elevation Above the Upper Reference Limit (URL) — 25; 22 participants
N/A N=109 Biochemical Effects of Remote Ischemic Pre-Conditioning on Contrast-induced Acute Kidney Injury
Contrast-induced Acute Kidney Injury
Primary: Number of Patients With Acute Kidney Injury — 8; 16 Participants
Phase 2 N=93 Combined Drug Approach to Prevent Ischemia-reperfusion Injury During Transplantation of Livers (CAPITL)
Reperfusion Injury
Primary: Peak Aspartate Aminotransferase Within First 72h Post Transplant — 1262.9; 1451.2 U/L
N/A N=321 Remote Ischemic Preconditioning in Neurological Death Organ Donors
Organ Transplantation
Primary: Number of Organs Recovered Per Donor — 3.79; 3.60 organs recovered per donor — p=0.38
N/A N=121 Remote Ischemic Conditioning (RIC) in Recipients of Brain Death Donor Livers - A Feasibility and Safety Study
Liver Failure · Carcinoma, Hepatocellular
Primary: Percentage of Participants Completing Entire Intervention Protocol — 70.96 percentage of participants
N/A N=99 Platelet Function in Resuscitated Patients
Acute ST Segment Elevation Myocardial Infarction
Primary: Platelet Inhibition Measured With Optical Aggregometry — 109; 253.8 AU*min
N/A N=1,500 Remote Ischemic Conditioning in Patients With Acute Stroke (RESIST)
Stroke, Acute · Ischemic Stroke · Hemorrhagic Stroke
Primary: Modified Rankin Scale at 3 Months in Acute Stroke (AIS and ICH) — 2; 1 units on a scale
Phase 2 N=103 The Neuroprotective Effect of Remote Ischemic Preconditioning on Ischemic Cerebral Vascular Disease
Cerebrovascular Disease
Primary: Blood Pressure and Heart Rates;
Phase 2 N=74 Reparixin in Prevention of Delayed Graft Function After Kidney Transplantation
Ischemia-Reperfusion Injury · Kidney Diseases
Primary: Creatinine Clearance (CrCl) in the Immediate Post-transplant Period — 5.11; 7.44; 6.30; 9.66 mL/min — p=0.9076
N/A N=20 Effect of Intermittent Pedicle Clamping on Hepatocellular Injury During Liver Surgery
Hepatocellular Injury · Blood Loss
Primary: Hepatocellular Damage Reflected by Liver Fatty-acid Binding Protein (L-FABP) Levels — 9097; 11,688 ng*h/mL