Phase 4
N=136
Miralax (PEG 3350) vs. Golytely as Bowel Preparation for Screening Colonoscopy
Colon Cancer
Bottom Line
View on ClinicalTrials.gov: NCT01170754 ↗Enrolled (actual)
136
Serious AEs
0.0%
Results posted
Jun 2016
Primary outcome: Primary: Boston Prep Scale — 7.0; 7.2 units on a scale — p=.45
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- PEG-3350 and Gatorade (Drug); Golytely 4 liters (Drug)
- Age
- Adult, Older Adult · 40+ yrs
- Sex
- All
- Sponsor
- Temple University
- Primary completion
- Jul 2011
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Boston Prep Scale |
7.0; 7.2 | .45 |
| SECONDARY Sodium Level in mmol/L |
138.8; 139.3 | .13 |
| SECONDARY Potassium Level in mmol/L |
4.0; 3.9 | .31 |
| SECONDARY Chloride Level in mmol/L |
104.1; 104.2 | .87 |
| SECONDARY Bicarbonate Level in mmol/L |
26.4; 25.9 | .25 |
| SECONDARY BUN Level in mg/dl |
9.0; 9.5 | .47 |
| SECONDARY Creatinine Level in mg/dl |
0.9; 1.1 | .34 |
| SECONDARY Glucose Level in mg/dl |
98.2; 93.7 | .18 |
| SECONDARY Calcium Level in mg/dl |
9.3; 9.3 | .75 |
| SECONDARY Magnesium Level in mg/dl |
2.1; 2.1 | .92 |
| SECONDARY Phosphorus Level in mg/dl |
3.4; 3.5 | .60 |
Summary
A major limitation to the widespread acceptance of colonoscopy as a procedure to screen for colorectal cancer is the laxative preparation. Phosphate-based preps (e.g. Fleets Phosphosoda) are now used on a limited basis because of their known association with renal injury. Polyethylene glycol (PEG) mixed with a balanced electrolyte solution (e.g. Golytely) has been used for over two decades for colon cleansing. The mixture is not very palatable due to the electrolyte additives which include sodium sulfate.
To overcome the limitation of existing preps, gastroenterologists and colorectal surgeons worldwide have been using PEG powder alone (same quantity as found in Golytely prep) not mixed with electrolytes (Glycolax or Miralax) and dissolving this into 64 ounces of Gatorade. Conservatively, we estimate that 25% of colonoscopies in the US are being done with this prep. Anecdotally there have been reports (case series) that it is far more palatable and the prep is equally efficacious. The active ingredient, PEG, is not changed and therefore this is not surprising. The issue at present is that there has never been a blinded study to confirm these claims.
This study will compare the efficacy of the two preps. There is no funding. The investigators will charge insurance companies for the prep - this is our current practice. The procedures will be done on healthy individuals referred for colon cancer screening and the exam will be billed to their insurance. There will be no patient honorarium. The investigators will check electrolytes to be sure patients do not develop hypokalemia with the Gatorade prep.
Eligibility Criteria
Inclusion Criteria
All adults undergoing average risk colon cancer screening (ages 40-75 years old)
•Able to provide informed consent
Exclusion Criteria
- A history of constipation
- Patients who use medications to assist with a bowel movement such as osmotic, stimulant, or cathartic laxatives (including "colon cleansers")
- Diabetes or glucose intolerance
- Patients with severe underlying renal or hepatic impairment
- Pregnant women - pregnancy test performed on all menstruating women before procedure.
Data sourced from ClinicalTrials.gov (NCT01170754). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.