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Colorectal Cancer

20 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Colorectal Cancer

532 trials tracked for Colorectal Cancer: 78 in phase 3 or 4 and 32 with published results. The most-cited published study has 2934 citations.

532Trials tracked

78Phase 3 & 4

0Recruiting

32With published results

Phase distribution

Phase 4 14 Phase 3 64 Phase 2 252 Phase 1 41 Other / NA 161

Phase 3 Study of Pembrolizumab (MK-3475) vs Standard Therapy in Participants With Microsatellite Instability-High (MSI-H) or Mismatch Repair Deficient (dMMR) Stage IV Colorectal Carcinoma (MK-3475-177/KEYNOTE-177) Completed · 2,934 cited
Phase 3 Study of TAS-102 in Patients With Metastatic Colorectal Cancer Refractory to Standard Chemotherapies Completed · 1,423 cited
Phase 3 Laparoscopic-Assisted Resection or Open Resection in Treating Patients With Rectal Cancer Completed · 1,092 cited
Phase 3 A Study to Investigate Efficacy and Safety of Cobimetinib Plus Atezolizumab and Atezolizumab Monotherapy Versus Regorafenib in Participants With Metastatic Colorectal Adenocarcinoma (COTEZO IMblaze370) Completed · 559 cited
Phase 3 Adjuvant HIPEC in High Risk Colon Cancer Completed · 318 cited
Phase 3 A Study of Efficacy and Safety of Fruquintinib (HMPL-013) in Participants With Metastatic Colorectal Cancer Completed · 317 cited

Show 44 more trials

Phase 3 A Trial to Compare Oxaliplatin, Folinic Acid (FA) and 5-Fluorouracil (5FU) Combination Chemotherapy (FOLFOX-4) With or Without Cetuximab in the 1st Line Treatment of Metastatic Colorectal Cancer (mCRC) in Chinese Rat Sarcoma Viral Oncogene Homolog (RAS) Wild-type Patients Completed · 257 cited
Phase 3 Study of Trifluridine/Tipiracil (TAS-102) in Patients With Metastatic Colorectal Cancer in Asia Completed · 255 cited
Phase 3 Panitumumab and RAS, Diagnostically-useful Gene Mutation for mCRC Completed · 254 cited
Phase 3 Calcium Gluconate and Magnesium Sulfate in Preventing Neurotoxicity in Patients With Colon Cancer or Rectal Cancer Receiving Oxaliplatin-Based Combination Chemotherapy Completed · 235 cited
Phase 3 BBI608 and Best Supportive Care vs Placebo and Best Supportive Care in Pretreated Advanced Colorectal Carcinoma Completed · 168 cited
Phase 3 Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus MOVIPREP® Using 2-Day Split-Dosing and 1-Day Morning Split-Dosing Regimen in Adults. Completed · 111 cited
Phase 3 Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus Trisulfate Solution Using 2-Day Split-Dosing Regimen in Adults Completed · 95 cited
Phase 3 Efficacy of Morning-only Bowel Preparation for Afternoon Colonoscopy. Completed · 85 cited
Phase 3 The Safety and Efficacy of Methylene Blue MMX® Modified Release Tablets Administered to Subjects Undergoing Screening or Surveillance Colonoscopy Completed · 84 cited
Phase 3 Study of Lenvatinib (MK-7902/E7080) in Combination With Pembrolizumab (MK-3475) Versus Standard of Care in Participants With Metastatic Colorectal Cancer (MK-7902-017/E7080-G000-325/LEAP-017) Completed · 76 cited
Phase 3 An Investigational Immunotherapy Study of Nivolumab With Standard of Care Therapy vs Standard of Care Therapy for First-Line Treatment of Colorectal Cancer That Has Spread Completed · 67 cited
Phase 3 Cetuximab and/or Bevacizumab Combined With Combination Chemotherapy in Treating Patients With Metastatic Colorectal Cancer Completed · 64 cited
Phase 3 Nintedanib (BIBF 1120) vs Placebo in Refractory Metastatic Colorectal Cancer (LUME-Colon 1) Completed · 64 cited
Phase 3 Oxaliplatin, Leucovorin Calcium, and Fluorouracil With or Without Celecoxib in Treating Patients With Stage III Colon Cancer Previously Treated With Surgery Completed · 42 cited
Phase 4 The Effect of Exparel on Post Operative Pain and Narcotic Use After Colon Surgery Completed · 36 cited
Phase 4 Miralax (PEG 3350) vs. Golytely as Bowel Preparation for Screening Colonoscopy Completed · 35 cited
Phase 3 Optimization of Bevacizumab Scheduling With Chemotherapy for Metastatic Colorectal Cancer Completed · 34 cited
Phase 4 Comparative Efficacy of Water & Indigo Carmine vs. Water or Air Method on Adenoma Detection Rate (ADR) - a Randomized Controlled Trial (RCT) Completed · 31 cited
Phase 4 Intraoperative TAP Block With Bupivacaine/Dexamethasone Against Liposomal Bupivacaine (Exparel®) Completed · 25 cited
Phase 3 Biological Mesh Closure of the Pelvic Floor After Extralevator Abdomino Perineal Resection for Rectal Cancer Completed · 25 cited
Phase 4 A Translational Study of Bevacizumab in Participants With Metastatic Colorectal Cancer Completed · 18 cited
Phase 3 Comparing Efficacy and Safety of Stivant (AryoGen Bevacizumab) Versus Avastin in Metastatic Colorectal Cancer Completed · 15 cited
Phase 3 Efficacy and Safety of Olaparib (MK-7339) With or Without Bevacizumab Compared to Bevacizumab With a Fluoropyrimidine in Unresectable or Metastatic Colorectal Cancer (CRC) (MK-7339-003/LYNK-003) Completed · 13 cited
Phase 3 A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Standard of Care in Subjects With Previously Treated Metastatic PD-L1 Positive Colorectal Cancer (MK-4280A-007) Completed · 4 cited
Phase 3 S0000D: Effect of Vitamin E and/or Selenium on Colorectal Polyps in Men Enrolled on SELECT Trial SWOG-S0000 Completed · 3 cited
Phase 3 Multicenter Randomized Parallel Group Phase III Study Comparing the Bowel Cleansing Efficacy, Safety and Tolerability of NER1006 Versus a Sodium Picosulfate and Magnesium Salt Solution Using Day Before-Only Dosing Regimen in Adults. Completed
Phase 4 A Study of Bevacizumab Plus 5-Flurouracil (5-FU) Based Doublet Chemotherapy as Neoadjuvant Therapy for Participants With Previously Untreated Unresectable Liver-Only Metastases From Colorectal Cancer Completed
Phase 4 A Study of Bevacizumab (Avastin) in Combination With Chemotherapy in Participants With Metastatic Cancer of the Colon or Rectum Completed
Phase 4 Patient Satisfaction With Propofol for Out Patient Colonoscopy Completed
Phase 4 Glucagon Use in Colonoscopies Completed
Phase 4 Efficacy and Patient Satisfaction of Miralax and Gatorade Versus Movi Prep Completed
Phase 4 Comparative Effectiveness of Split-Dose Colonoscopy Bowel Preparation Regimens Completed
Phase 4 A Study of Xeloda (Capecitabine) as Adjuvant Monotherapy in Patients With Colon Cancer. Completed
Phase 4 Improvement of Fluid Balance in Patients Undergoing Surgery of the Colon and Rectum Completed
Phase 4 OBELIX Study: A Study of Avastin (Bevacizumab) in Combination With XELOX in Patients With Metastatic Cancer of the Colon or Rectum. Completed
Phase 3 Comparison of Survival Benefit of Panitumumab With Supportive Care to Best Supportive Care Alone in Patients With Metastatic Colorectal Cancer Completed
Phase 3 A Study of Xeloda (Capecitabine) Compared With 5-Fluorouracil in Combination With Low-Dose Leucovorin in Patients Who Have Undergone Surgery for Colon Cancer Completed
Phase 3 A Study of Bevacizumab (Avastin) in Combination With Chemotherapy in Participants With Metastatic Cancer of the Colon or Rectum. Completed
Phase 3 Open-label, Single Arm Trial of BI 695502 in Patients With Previously Untreated Metastatic Colorectal Cancer Completed
Phase 3 A Study of Napabucasin (BBI-608) in Combination With FOLFIRI in Adult Patients With Previously Treated Metastatic Colorectal Cancer Completed
Phase 3 Rifaximin and Placebo in the Treatment of Bowel Dysfunction After Anterior Resection for Rectal Cancer Completed
Phase 3 A Study of Coformulated Favezelimab/Pembrolizumab (MK-4280A) Versus Standard of Care in Subjects With Previously Treated Metastatic PD-L1 Positive Colorectal Cancer (MK-4280A-007)-China Extension Study Completed
Phase 3 Initial Attack on Latent Metastasis Using TAS-102 for ct DNA Identified Colorectal Cancer Patients After Curative Resection Completed
Phase 3 A Study of Capecitabine (Xeloda) and Bevacizumab as a First-line Therapy in Patients With Metastatic Colorectal Cancer Completed

Showing the 50 most-cited and recently-updated of 532 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

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Questions about Colorectal Cancer

How do specific mutations affect treatment response in Colorectal Cancer?

Specific mutations like KRAS, BRAF, and MMR status strongly influence treatment response in colorectal cancer, guiding targeted therapy and immunotherapy decisions.

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What factors affect the quality of life for survivors of Colorectal Cancer?

Quality of life for colorectal cancer survivors is influenced by physical symptoms, psychological distress, social support, self-efficacy, and demographic factors like age and gender.

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How does gut microbiota relate to the development of Colorectal Cancer?

Gut microbiota imbalances, including harmful bacteria like Fusobacterium nucleatum, can promote colorectal cancer through inflammation, DNA damage, and immune disruption, while beneficial microbes may offer protection.

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What are the challenges of using artificial intelligence for Colorectal Cancer treatment?

AI in colorectal cancer treatment faces challenges including data quality and privacy issues, lack of generalizability, interpretability problems, and regulatory validation hurdles.

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Can home exercise help reduce fatigue and anxiety in Colorectal Cancer patients?

Yes, home exercise may help reduce fatigue and anxiety in colorectal cancer patients, but the evidence is low certainty and more research is needed.

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See all 5 questions about Colorectal Cancer →

All Colorectal Cancer Articles