Phase 4
N=83
Remission Evaluation of Metabolic Interventions in Type 2 Diabetes (REMIT Pilot Trial)
Type 2 Diabetes Mellitus
Bottom Line
View on ClinicalTrials.gov: NCT01181674 ↗Enrolled (actual)
83
Serious AEs
0.0%
Results posted
May 2020
Primary outcome: Primary: Normoglycemia on Therapy — 14; 1; 19; 1 Participants
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- insulin glargine (Drug); metformin (Drug); acarbose (Drug); lifestyle therapy (Behavioral); Standard glycemic care (Other)
- Age
- Adult, Older Adult · 30+ yrs
- Sex
- All
- Sponsor
- Population Health Research Institute
- Primary completion
- Feb 2015
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Normoglycemia on Therapy |
14; 1; 19; 1 | — |
| SECONDARY 1) Percentage of Participants With Normal Glucose Tolerance in the Experimental Group 1 Compared to the Control Group. 2) Percentage of Participants With Normal Glucose Tolerance in the Experimental Group 2 Compared to the Control Group. |
2; 2; 2; 1 | — |
| SECONDARY Percentage of Participants With Normal Fasting Plasma Glucose |
5; 5; 3 | — |
| SECONDARY Change in Fasting Plasma Glucose From Baseline |
-0.23; -0.64; 0.05 | — |
| SECONDARY HbA1C |
6.1; 6.0; 6.6; 6.2; 6.1; 6.6 | — |
| SECONDARY Change in Weight From Baseline |
99.5; 95.3; 89.3; 95.3; 92.4; 87.1 | — |
| SECONDARY Number of Participants With Symptomatic Hypoglycemic Episodes |
9; 10; 1 | — |
| SECONDARY Number of Participants With Severe Hypoglycemic Episodes |
0; 0; 0 | — |
Summary
The purpose of this pilot trial is to determine whether an intensive treatment with insulin glargine, metformin, acarbose and lifestyle can normalize blood glucose levels in patients with recently diagnosed type 2 diabetes mellitus when compared to standard diabetes care.
Eligibility Criteria
Inclusion Criteria
- men and women 30-80 years of age inclusive
- type 2 diabetes mellitus diagnosed by a physician within 3 years prior to patient enrollment
- anti-diabetic drug regimen (either drug or dose of drug) unchanged during 8 weeks prior to screening and randomization
- HbA1C ≤ 8.5% on no oral hypoglycemic agents or HbA1C ≤ 7.5% on 1 agent or on half-maximal doses of 2 agents
- body mass index ≥ 23 kg/m2
- a negative pregnancy test and an agreement to use a reliable method of birth control for the duration of the trial in all females with childbearing potential
- ability and willingness to perform self-monitoring of capillary blood glucose (SMBG)
- ability and willingness to self-inject insulin
- provision of informed consent.
Exclusion Criteria
- current use of insulin therapy
- history of hypoglycemia unawareness, or severe hypoglycemia requiring assistance
- renal dysfunction as evidenced by serum creatinine (Cr) ≥ 124 μmol/l
- history of lactic acidosis or diabetic ketoacidosis
- active liver disease or elevated alanine transferase (ALT) levels ≥ 2.5 times upper limit of normal at the time of enrollment
- history of inflammatory bowel disease, colonic ulcers, recent or significant bowel surgery, or predisposition to bowel obstruction
- cardiovascular disease including any of:
- systolic blood pressure >180 mmHg or diastolic blood pressure >105 mmHg
- peripheral vascular disease
- left bundle branch block or third degree AV block
- tachyarrhythmias or bradyarrhythmias with uncontrolled ventricular rate
- stenotic valvular heart disease
- cardiomyopathy
- history of heart failure
- history of aortic dissection
- documented history of angina or coronary artery disease
- history of stroke or transient ischemic attack
- pulmonary disease with dependence on oxygen
- history of any disease requiring intermittent or continuous systemic glucocorticoid treatment
- history of any major illness with a life expectancy of <3 years
- history of injury or any other condition that significantly limits participant's ability to achieve moderate levels of physical activity
- any history of excessive alcohol intake, acute or chronic
- known hypersensitivity to metformin, acarbose, or insulin glargine.
Data sourced from ClinicalTrials.gov (NCT01181674). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.