SGLT2 inhibitors provide robust prognostic benefits in heart failure with inconsistent results in post-myocardial infarction settings
SGLT2 inhibitors show promise for heart failure and diabetes
This narrative review examines the cardiovascular and metabolic effects of SGLT2 inhibitors, specifically empagliflozin and dapagliflozin. T…
New evidence shows how SGLT2 inhibitors may protect the heart and manage risks for patients with type 2 diabetes and heart failure.
Metformin is associated with higher lactate concentrations during exercise in adults with prediabetes and type 2 diabetes
Metformin May Raise Lactate During Exercise
This meta-analysis of 325 participants evaluated the impact of metformin on exercise metabolism and capacity. The analysis found that metfor…
A new analysis suggests metformin may increase lactate levels during exercise, which could affect workout intensity.
Preoperative comorbidities linked to reduced weight loss after metabolic and bariatric surgery in adults
Pre-existing health conditions may slightly reduce weight loss after surgery
A meta-analysis of twenty-three studies reveals that mental illness, diabetes, and sleep apnea are associated with slightly lower weight los…
Adults with mental illness or diabetes before surgery saw slightly less weight loss. Other conditions like high blood pressure did not affec…
Eating later in the biological day is associated with impaired glucose regulation and reduced insulin sensitivity
Eating later in the day is linked to worse blood sugar and heart health markers
This narrative review examines chrononutrition in obesity, type 2 diabetes, hypertension, and cardiovascular disease. Findings indicate that…
A review suggests eating later in the biological day is associated with impaired glucose regulation and reduced insulin sensitivity in peopl…
37 loci linked to gestational diabetes, 7 novel, in large multi-ancestry meta-analysis
Scientists found new genetic links to diabetes during pregnancy in this large study
This meta-analysis of genome-wide association studies across up to 38,305 GDM cases and 776,145 controls identified 37 loci associated with …
A massive study looked at DNA from many people to find genes linked to diabetes in pregnancy. They discovered new genetic markers that help …
Probiotics, synbiotics, and berberine modestly lower fasting glucose and HbA1c in type 2 diabetes
Probiotics and Berberine Modestly Lower Blood Sugar in Type 2 Diabetes
This meta-analysis of over 2,000 participants found that probiotics, synbiotics, and berberine produced significant but modest reductions in…
Probiotics, synbiotics, and berberine may help lower blood sugar and HbA1c, but the effects are modest.
Narrative review proposes FISI tools for metabolic syndrome and diabetes management across the life cycle
New tools for managing metabolic syndrome and diabetes types
This narrative review discusses the Dietary Inflammatory Index (DII) versus the Food Inflammation Index (FII) in the context of Metabolic Sy…
A review proposes new dietary tools like C-FISI and P-FISI to help manage metabolic syndrome and diabetes across a person's life.
Case report and review of literature on acute NSTEMI after fluorescein angiography in a 76-year-old woman
Rare heart attack possible after fluorescein angiography in older adults with heart disease
This case report and review of the literature describes a 76-year-old woman with hypertension, hyperlipidemia, and type 2 diabetes mellitus …
A 76-year-old woman with heart disease had a heart attack shortly after a dye test, highlighting rare risks.
Network meta-analysis compares bexagliflozin efficacy and safety with other SGLT2 inhibitors in type 2 diabetes
New analysis shows bexagliflozin helps lower blood sugar and weight in adults with type 2 diabetes compared to other drugs
This systematic review and network meta-analysis synthesized evidence on bexagliflozin versus other SGLT2 inhibitors and placebo in adults w…
A large review of 26,838 patients found bexagliflozin lowers blood sugar and weight well. It also lowers blood pressure and causes fewer inf…
Pediatric Gut Microbiome Links to Metabolic Dysfunction-Associated Steatotic Liver Disease and Type 2 Diabetes
Your Child's Gut Health May Protect Against Fatty Liver Disease
Current literature reveals complex associations between the pediatric gut microbiome and metabolic dysfunction-associated steatotic liver di…
• Specific gut bacteria patterns predict fatty liver risk in children • Helps parents of overweight kids with diabetes or obesity • Not read…
Systematic review and meta-analysis on VR for Type 2 Diabetes management
Virtual Reality Lowers Blood Sugar Without Extra Gym Time for Diabetics
This systematic review and meta-analysis synthesized evidence on virtual reality interventions for adults with Type 2 Diabetes. The analysis…
• VR cuts blood sugar levels by half a point on average • Helps adults managing type 2 diabetes at home • Works as well as current methods b…
Systematic review and meta-analysis of HIIT versus MICT for Type 2 Diabetes outcomes
High-Intensity Interval Training Helps Lower Blood Sugar and Improve Heart Health for People With Type 2 Diabetes
This systematic review and meta-analysis evaluated High-Intensity Interval Training (HIIT) against Moderate-Intensity Continuous Training (M…
A review of eight studies found that high-intensity interval training works better than steady exercise for lowering fasting blood sugar and…
Research across Type 2 Diabetes
Related studies from across the Type 2 Diabetes family.
Resveratrol supplementation significantly reduces LDL-C but lacks consistent impact on glycemic indices in type 2 diabetes
Resveratrol fails to improve blood sugar in type 2 diabetes
This umbrella review and meta-analysis of 10 meta-analyses evaluated resveratrol for managing type 2 diabetes. While a significant reduction…
Resveratrol supplements did not lower blood sugar or improve cholesterol in type 2 diabetes, except for a small drop in LDL cholesterol.
SGLT2 inhibitors associated with lower all-cause mortality in heart transplant recipients with type 2 diabetes
SGLT2 inhibitors associated with lower mortality in heart transplant patients
This meta-analysis examined the impact of SGLT2 inhibitor use on outcomes for heart transplant recipients with type 2 diabetes. The authors …
New analysis suggests SGLT2 inhibitors may lower death rates for heart transplant recipients with type 2 diabetes without increasing UTI ris…
Single-incision sleeve plus bypass shows short-term safety and metabolic improvement in 3 patients with obesity and T2DM
SILSG-JJB Procedure Shows Promise for Weight Loss and Diabetes
This case report and review describes 3 female patients with severe obesity and type 2 diabetes who underwent single-incision laparoscopic s…
A new surgical approach may help people with severe obesity and Type 2 Diabetes achieve weight loss and better blood sugar levels.
Transcriptomic analysis identifies 337 high-confidence genes associated with Type 2 Diabetes in human pancreatic islets
Meta-analysis reveals 337 genes linked to type 2 diabetes in islets
This meta-analysis of transcriptomic data from human pancreatic islets identified 337 high-confidence T2D-associated genes. The study also d…
A meta-analysis of human pancreatic islets identified 337 high-confidence genes tied to type 2 diabetes, and a 10-gene panel perfectly disti…
Semaglutide reduces risk of kidney decline or death in type 2 diabetes and CKD
Semaglutide lowers kidney and heart risks in type 2 diabetes patients
This randomized controlled trial enrolled 3,533 participants with type 2 diabetes and chronic kidney disease. Once-weekly subcutaneous semag…
A large trial shows once-weekly semaglutide reduces kidney failure and death risks in people with type 2 diabetes and chronic kidney disease…
GLP-1 receptor agonists may reduce cognitive decline in type 2 diabetes patients with dementia
GLP-1 drugs may slow cognitive decline in type 2 diabetes
A systematic review of systematic reviews and meta-analyses found that GLP-1 receptor agonists are associated with reduced overall cognitive…
A review of reviews suggests GLP-1 drugs like Ozempic may help protect memory and thinking in people with type 2 diabetes.
Evolocumab reduces cardiovascular events in diabetes without known atherosclerosis
Evolocumab cuts heart events in high-risk diabetes patients
This prespecified subgroup analysis of a phase 3 RCT evaluated evolocumab added to statin therapy in 3655 high-risk patients with type 2 dia…
Adding evolocumab to statins reduced heart attacks and strokes by about 30% in high-risk diabetes patients without known heart disease.
Insulin degludec/liraglutide ranks highest for HbA1c reduction with SUCRA value of 89.4%
Comparing Combination Diabetes Drugs for Blood Sugar Control
This network meta-analysis evaluated 12,815 patients with type 2 diabetes to compare fixed-ratio combination products and their individual c…
A review of 12,815 patients found that insulin degludec/liraglutide may be best for lowering blood sugar, but has more side effects than oth…
scFv-based biologics show potential for immunomodulation in type 1 and type 2 diabetes
Review explores scFv biologics for Type 1 and Type 2 diabetes care
This narrative review explores the potential of single-chain variable fragment (scFv)-based biologics for treating type 1 and type 2 diabete…
This review looks at scFv-based biologics for diabetes. It discusses how these treatments might help with immune control and blood sugar bal…
Long-term voglibose use likely caused leukopenia in a 71-year-old man with type 2 diabetes
Switching diabetes drugs reversed low white blood cell counts in a 71-year-old man
This case report describes a 71-year-old male with well-controlled type 2 diabetes who developed leukopenia after long-term voglibose use. W…
A 71-year-old man with type 2 diabetes saw his white blood cell count rise after switching from voglibose to acarbose, suggesting the first …
Metabolic subtypes identify Japanese adults with prediabetes at highest or lowest T2D risk
Japanese adults with prediabetes benefit most from lifestyle changes in one specific metabolic group
This randomized controlled trial enrolled 295 Japanese adults with impaired glucose tolerance in the Japanese Diabetes Prevention Program. P…
A study of 295 Japanese adults found that lifestyle changes work best for those with a specific metabolic pattern. This group had the lowest…
GLP-1RAs show lower risk of serious liver events compared with DPP-4 inhibitors in adults with type 2 diabetes
GLP-1 drugs may lower serious liver risks compared to DPP-4 inhibitors in type 2 diabetes
This systematic review and exploratory meta-analysis evaluated incident cirrhosis or composite serious liver events among adults with type 2…
A new analysis suggests GLP-1 receptor agonists might reduce serious liver events compared to DPP-4 inhibitors for adults with type 2 diabet…
Questions about Type 2 Diabetes Mellitus
Does a higher nutritional risk index lower osteoporosis risk in women with Type 2 Diabetes?
Yes, a higher Geriatric Nutritional Risk Index (GNRI) is linked to lower osteoporosis risk in women with type 2 diabetes, based on multiple studies.
Full answer →Which glucose-lowering therapies work best for heart failure and Type 2 Diabetes?
SGLT-2 inhibitors (like empagliflozin, dapagliflozin) are the most effective glucose-lowering therapies for heart failure in type 2 diabetes, reducing hospitalizations and cardiovascular death.
Full answer →All Type 2 Diabetes Mellitus Articles
- SGLT2 inhibitors provide robust prognostic benefits in heart failure with inconsistent results in post-myocardial infarction settings
- Metformin is associated with higher lactate concentrations during exercise in adults with prediabetes and type 2 diabetes
- Preoperative comorbidities linked to reduced weight loss after metabolic and bariatric surgery in adults
- Eating later in the biological day is associated with impaired glucose regulation and reduced insulin sensitivity
- 37 loci linked to gestational diabetes, 7 novel, in large multi-ancestry meta-analysis
- Probiotics, synbiotics, and berberine modestly lower fasting glucose and HbA1c in type 2 diabetes
- Narrative review proposes FISI tools for metabolic syndrome and diabetes management across the life cycle
- Case report and review of literature on acute NSTEMI after fluorescein angiography in a 76-year-old woman
- Systematic review and meta-analysis on VR for Type 2 Diabetes management
- Pediatric Gut Microbiome Links to Metabolic Dysfunction-Associated Steatotic Liver Disease and Type 2 Diabetes
- Network meta-analysis compares bexagliflozin efficacy and safety with other SGLT2 inhibitors in type 2 diabetes
- Systematic review and meta-analysis of HIIT versus MICT for Type 2 Diabetes outcomes
- Network meta-analysis compares glucose-lowering therapies for heart failure with reduced ejection fraction and type 2 diabetes
- Afternoon/Evening Exercise May Lower Blood Pressure More Than Morning Exercise: Meta-Analysis
- Semaglutide high dose for weight reduction in people with Type 2 Diabetes
- Telemedicine applications in general practice show positive clinical outcomes for chronic diseases
- Combination valsartan and dapagliflozin improves blood pressure and glucose in Type 2 Diabetes and hypertension
- Observational Study Evaluating Hospital-Based Chronic Disease Management Platform in Adults With Type 2 Diabetes
- Scoping review on AI fundus photography for Type 2 Diabetes highlights limited external validation and calibration
- Higher Geriatric Nutritional Risk Index linked to lower osteoporosis risk in diabetic women
- Systematic review suggests resveratrol may improve glycemic control and protect pancreatic beta-cell function in diabetes
- Non-traditional lipid indices associate with coronary heart disease risk in MASLD and type 2 diabetes patients
- Narrative review compares tirzepatide and semaglutide for obesity and type 2 diabetes outcomes
- IGFBP2 as a context-dependent regulator of metabolic dysregulation in obesity and type 2 diabetes
- Systematic review and meta-analysis of oxidative stress biomarkers in older adults with T2DM or Parkinson's disease
- Literature review synthesizes Schisandra chinensis effects on gut microbiota and metabolic pathways across multiple conditions
- SBSPON gene variant rs2291219 linked to higher T2DM risk in Northwest Indian population
- Bioinformatics study identifies shared immune genes and potential drugs for PCOS and T2DM
- Systematic review and meta-analysis of Mendelian randomization studies examining T2DM and cancer associations
- Multidisciplinary management in T2DM patients yielded a 29.24% remission rate in a single-arm observational study
- GLP-1RA use shows sex-specific pancreatitis and hypotension risks in T2D second-line therapy study
- MTHFR C677T polymorphism linked to elevated risk of schizophrenia and type 2 diabetes comorbidity in Han Chinese patients
- Single-dose fultagliptin benzoate pharmacokinetics and safety in patients with mild to moderate renal insufficiency versus healthy volunteers
- Circulating spexin levels are significantly lower in patients with type 2 diabetes mellitus compared to controls
- Meta-analysis identifies risk factors for diabetic kidney disease in Asian patients with type 2 diabetes
- Protocol compares Mediterranean and low-carb diets for diabetes remission in Lebanese adults
- Network meta-analysis finds acupuncture therapies may improve glycemic parameters in type 2 diabetes
- Anal fistula incidence higher in diabetic patients; current management strategies may be suboptimal
- Elevated plasma phenylalanine associated with obesity, type 2 diabetes, and cancer risk
- AI-ready dataset created for type 2 diabetes research, lacking clinical validation
- Structured exercise program improves glycemic control and fitness in Bangladeshi adults with type 2 diabetes
- Phase 4 trial compares pioglitazone versus dapagliflozin add-on in type 2 diabetes
- CT radiomics nomogram combining vertebral, muscle features shows AUC 0.956 for T2DM diagnosis