Phase 4 Completed N=72 Randomized Treatment

Hospital Insulin Protocol Aims for Glucose Control in Corticosteroid-induced Hyperglycemia

Hyperglycemia

Source: ClinicalTrials.gov NCT01184014 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Nov 2013

Primary outcomePrimary: Mean Blood Glucose of All Readings — 157.2; 181.8 mg/dL

Summary

The objective of this study is to determine the best insulin regimen for hospitalized patients who receive high doses of steroids who have high blood glucose.

Outcome Measures

Outcome	Result	p-value
PRIMARY Mean Blood Glucose of All Readings	157.2; 181.8	—

Eligibility Criteria

Inclusion Criteria

Men or women aged ≥18 years who receive steroids in doses greater than physiologic replacement levels of ≥ 10 mg Prednisone or its equivalent of dexamethasone or methylprednisolone.
Have signed the consent form for the study
Have a BG > 180 mg/dL any time during the first 24 hour of steroid administration that is above physiological replacement ( ≥ 10 mg Prednisone or equivalent)
Are scheduled to be in hospital ≥ 2 days.

Exclusion Criteria

Unable to read or understand English
History of psychiatric disability affecting informed consent or compliance with drug intake
Type 1 diabetes
Acute or chronic renal failure (creatinine clearance < 30 mL/min estimated by method of Cockcroft and Gault)
Patients in Hospice Care
Age <18 years
Previously enrolled in this study.
Not appropriate for the steroid protocol in judgment of the principal investigator and/or attending physician.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01184014). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.