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Home › Conditions › Hyperglycemia

Hyperglycemia

Part of Postprandial Hyperglycemia

13 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Hyperglycemia

48 trials tracked for Hyperglycemia: 18 in phase 3 or 4 and 4 with published results. The most-cited published study has 422 citations.

48Trials tracked
18Phase 3 & 4
0Recruiting
4With published results
Phase distribution
Phase 4 15 Phase 3 3 Phase 2 6 Other / NA 24
  1. Phase 4 Insulin for Hyperglycemia in Stroke Trial Completed · 422 cited
  2. Phase 3 Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial Completed · 421 cited
  3. Phase 4 Study of Glycemic Control on Liver Transplantation Outcomes Completed · 21 cited
  4. Phase 4 Remifentanil and Glycemic Response in Cardiac Surgery Completed · 19 cited
  5. Phase 4 The Management of Glucocorticoid-Induced Hyperglycemia in Hospitalized Patients Completed
  6. Phase 4 Sitagliptin in Non-Diabetic Patients Undergoing General Surgery Completed
Show 42 more trials
  1. Phase 4 Sitagliptin for Hyperglycemia in Patients With T2DM Undergoing Cardiac Surgery Completed
  2. Phase 4 Intravenous Exenatide in Coronary Intensive Care Unit (ICU) Patients Completed
  3. Phase 4 Hospital Insulin Protocol Aims for Glucose Control in Corticosteroid-induced Hyperglycemia Completed
  4. Phase 4 A Randomized Clinical Trial To Study Losartan On Endothelial Dysfunction and Insulin Resistance In Obese Patients Completed
  5. Phase 4 Dipeptidyl Peptidase-4 Inhibitor (Sitagliptin) Therapy in the Inpatients With Type 2 Diabetes Completed
  6. Phase 4 Basal Bolus Versus Basal Insulin in Type 2 Diabetes Mellitus (T2DM) Completed
  7. Phase 4 Conversion of Hyperglycemic Patients Being Treated With Intravenous Insulin Infusions to Lantus Insulin Completed
  8. Phase 4 Diabetes in the Elderly: Prospective Study Completed
  9. Phase 4 Strict Glycemic Control by Insulin Infusion:Observations on Emergency Department Initiation Completed
  10. Phase 4 Ketosis-Prone Diabetes Mellitus (KPDM): Metformin Versus Sitagliptin Treatment Completed
  11. Phase 3 Safety and Efficacy Study of Empagliflozin and Metformin for 24 Weeks in Treatment Naive Patients With Type 2 Diabetes Completed
  12. Phase 3 Computerized Glucose Control in Critically Ill Patients Completed
  13. Phase 2 Intravenous Exenatide (Byetta) During Surgery Completed
  14. Phase 2 Glucose Regulation in Acute Stroke Patients (GRASP) Study Completed
  15. Phase 2 Expanding Use of CGM in Critical Care: Impact on Nurse Work Patterns and Patient Outcomes Completed
  16. Phase 2 The Effects of Metformin on Blood Vessel Structure and Function Completed
  17. Phase 2 Somatostatin Analogue SOM230 (Pasireotide) in Healthy Male Volunteers Completed
  18. Phase 2 Early Insulin and Development of ARDS Completed
  19. N/A Continuous Glucose Monitoring for Hyperglycemia in Critically Ill Patients Completed
  20. N/A The Effect of Tight Glycemic Control on Surgical Site Infection Rates in Patients Undergoing Open Heart Surgery Completed
  21. N/A Feasibility Study to Evaluate Safety and Device Performance of the Hospital Glucose Management System (HGMS) Completed
  22. N/A TPN-Induced Hyperglycemia: Impact on Clinical Outcome in Intensive Care Unit (ICU) and Non-ICU Patients Completed
  23. N/A MedStar Health Type 2 Diabetes Pathway to Control Completed
  24. N/A Procoagulant Effects of Hyperglycemia After Acute Stroke: A Pilot Study Completed
  25. N/A Glucose and Lipid Metabolism on Antipsychotic Medication Completed
  26. N/A The Synergy to Control Emergency Department Hyperglycemia Program for Type 2 Diabetes Completed
  27. N/A Low-Carbohydrate Dietary Pattern on Glycemic Outcomes Trial Completed
  28. N/A Inpatient Closed-loop Glucose Control Completed
  29. N/A Impact of Consumption of Beta-glucans on the Intestinal Microbiota and Glucose and Lipid Metabolism Completed
  30. N/A Effectiveness and Cost-Effectiveness of Fully-Automated Digital vs. Human Coach-Based Diabetes Prevention Programs Completed
  31. N/A Intervening in Diabetes With Healthy Eating, Activity, and Linkages To Healthcare - The I-D-HEALTH Study Completed
  32. N/A Green Tea Confections For Managing Postprandial Hyperglycemia-Induced Vascular Endothelial Dysfunction Completed
  33. N/A Comparative Trial Between 3 Types of Insulin Infusion Protocols Completed
  34. N/A Insulin Secretion in Diabetes Before and After Glycemic Control Completed
  35. N/A Feasibility and Acceptability of a Beverage Intervention for Hispanic Adults Completed
  36. N/A SPECS: Safe Pediatric Euglycemia in Cardiac Surgery Completed
  37. N/A Ischemia/Reperfusion Injury of Human Endothelium: Role of Glucose and Statins Completed
  38. N/A The Effect of the Hyperinsulinemic Normoglycemic Clamp on Myocardial Function and Utilization of Glucose Completed
  39. N/A Hyperglycemia and Mitochondrial Function in The Endothelium of Humans Completed
  40. N/A Healthy Volunteers Study of the Effects of Olanzapine and Ziprasidone Completed
  41. N/A Effects of a Complete Diet in Critically Ill Patients With Stress Hyperglycemia Completed
  42. N/A IV Insulin Protocol in Diabetes and Renal Transplantation Completed

Showing the 48 most-cited and recently-updated of 48 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Hyperglycemia: what the trials found

Management of hyperglycemia through various insulin formulations and adjuncts shows varied outcomes in clinical settings. Insulin glargine was evaluated for glycemic control, showing no significant difference in average daily glucose levels or the percentage of participants maintaining target ranges [7, 10]. In a study comparing different insulin regimens (Basal Plus, Basal-bolus, and SSRI), the SSRI group demonstrated significantly fewer hypoglycemia events compared to other regimens 13. Additionally, one trial noted that specific insulin glargine protocols resulted in varying percentages of blood glucose values within target ranges and differing rates of hyperglycemia (>180 mg/dL) 16.

Sitagliptin was evaluated in hospital settings; it was associated with a lower number of patients with mean daily blood glucose >240 mg/dL compared to other groups, and showed no significant difference in the length of stay 12. Sitagliptin also demonstrated a reduction in ICU stay duration 6. Exenatide was shown to significantly reduce median glucose values from steady state through 48 hours or until discharge, while also reducing time to steady state 11. Metformin was utilized in several trials for glycemic management [8, 18, 22], with one study showing significant reductions in HbA1c and fasting plasma glucose (FPG) at 24 weeks 18.

In acute settings, the use of remifentanil was associated with significantly lower instances of blood glucose >180 mg/dL and a reduced requirement for insulin compared to other conditions 4. Intensive IV insulin protocols aimed at maintaining target concentrations did not show significant differences in clinical outcomes like Modified Rankin Scale or NIHSS scores, but were associated with a significant reduction in severe hypoglycemia 17. One study noted that insulin administration was associated with lower infection rates and lower rates of hypoglycemia in specific patient populations 3.

Recent results — preliminary, needs further review

  • Dexcom G6 monitoring showed significantly different percentages of time spent in target glycemic ranges across various groups (p<0.001) 1.
  • Exenatide 0.27 ng/kg/min was evaluated for maintaining intraoperative euglycemia, but the results did not reach statistical significance (p=0.05) 20.

For the clinician treating this condition

  • Sitagliptin is associated with fewer patients reaching high mean daily glucose levels (>240 mg/dL) and shorter ICU stays [6, 12].
  • Exenatide significantly reduces median glucose values and shortens the time to reach a steady state in clinical settings 11.
  • Metformin demonstrates significant reductions in HbA1c and fasting plasma glucose over a 24-week period 18.
  • Intensive IV insulin protocols can reduce the incidence of severe hypoglycemia (blood glucose <40 mg/dL) but do not necessarily improve functional outcomes like NIHSS or Modified Rankin Scale scores 17.

AI synthesis of 11 cited trials, updated Jun 29, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Enteral nutrition is associated with 30% to 80% incidence of hyperglycemia in critically ill patients
Diabetes & Endocrinology Meta-analysis
Enteral nutrition is associated with 30% to 80% incidence of hyperglycemia in critically ill patients Enteral Nutrition Linked to High Blood Sugar in ICU Patients
This systematic review of 45 studies examines enteral nutrition-related hyperglycemia in ICU and post-cardiac surgery populations. The revie…
Patients receiving enteral nutrition in intensive care units may face high blood sugar levels, especially following cardiac surgery.
Frontiers Jul 7, 2026
Pitaya by-products show antioxidant, anti-inflammatory, hypolipidemic, and hypoglycemic potential in systematic review
Nutrition & Obesity Medicine Sys. Review
Pitaya by-products show antioxidant, anti-inflammatory, hypolipidemic, and hypoglycemic potential in systematic review Pitaya By-products Show Potential for Managing Blood Sugar and Cholesterol
This systematic review of pitaya (Selenicereus spp.) by-products finds they are rich in bioactive compounds and exhibit antioxidant, anti-in…
Discarded parts of the pitaya fruit, like seeds and peels, contain compounds that may help manage high blood sugar and cholesterol levels.
Frontiers Jul 7, 2026
Ultramarathon running alters glucose dynamics in three distinct phases
Drug Pipeline Sys. Review
Ultramarathon running alters glucose dynamics in three distinct phases Glucose spikes during ultramarathons may not match standard diet or exercise rules
This mini-review synthesizes evidence on glucose dynamics during ultramarathon running, describing three phases: transient elevation, gradua…
A mini-review of ultramarathon runners shows blood glucose patterns that standard models cannot fully explain, suggesting new ways to manage…
Frontiers May 29, 2026
Meta-analysis links moderate-to-severe obstructive sleep apnea to higher metabolic syndrome risk in patients
ENT (Otolaryngology) Meta-analysis
Meta-analysis links moderate-to-severe obstructive sleep apnea to higher metabolic syndrome risk in patients Patients with worse sleep apnea face higher risks for diabetes and high blood pressure compared to those with milder cases
This meta-analysis evaluated the association between obstructive sleep apnea syndrome (OSAS) severity and metabolic syndrome risk. The poole…
A large review of over ten thousand patients shows that worse sleep apnea greatly increases the chance of getting metabolic syndrome, high b…
Frontiers May 15, 2026
Systematic Review and Meta-Analysis of Subcutaneous CGM in Elective Surgery
Diabetes & Endocrinology Sys. Review
Systematic Review and Meta-Analysis of Subcutaneous CGM in Elective Surgery New sensors catch low blood sugar missed by standard checks during surgery
This systematic review and meta-analysis of 557 adults undergoing elective surgery found that subcutaneous continuous glucose monitoring (CG…
New glucose sensors catch dangerous low blood sugar drops during surgery that standard checks completely miss, helping doctors keep patients…
medRxiv May 8, 2026
Baseline anti-GIP antibody levels associate with future diabetes-range glycemia in health checkup cohort
Diabetes & Endocrinology Cohort
Baseline anti-GIP antibody levels associate with future diabetes-range glycemia in health checkup cohort Certain Antibodies Might Warn Of Rising Blood Sugar Levels
This prospective cohort study followed 218 participants undergoing health checkups for a mean of 8.1 years.
New research shows specific antibodies in blood may predict diabetes risk years before symptoms start and offer new clues for prevention.
Frontiers Apr 29, 2026
Admission blood glucose levels associated with NRDS severity in neonates
Pediatrics Cohort
Admission blood glucose levels associated with NRDS severity in neonates High blood sugar linked to worse breathing in newborns with lung distress
This retrospective cohort study of 219 neonates with NRDS at a tertiary hospital in China found that hyperglycemia at admission was associat…
Newborns with high blood sugar had more severe breathing trouble and needed longer support than those with normal sugar levels.
Frontiers Apr 23, 2026
Endocrinologist-led glucose management with RT-CGM and insulin infusion improved glycemic control and reduced infections in adult EICU patients
Diabetes & Endocrinology Cohort
Endocrinologist-led glucose management with RT-CGM and insulin infusion improved glycemic control and reduced infections in adult EICU patients ICU Blood Sugar Control Gets a Game-Changing Upgrade
This retrospective before-after study evaluated 1138 adult EICU patients with stays ≥24 hours.
A new ICU blood sugar control method slashes dangerous highs and infections while keeping critically ill patients safer.
Frontiers Apr 20, 2026
CAR T-cell therapy linked to endocrine adverse events in FAERS analysis
Rheumatology Cohort
CAR T-cell therapy linked to endocrine adverse events in FAERS analysis CAR T-cell therapy may trigger rare but serious hormone problems like adrenal failure
A retrospective disproportionality analysis and literature review of 269 endocrine adverse event reports from the FAERS database (2017 to Q2…
CAR T-cell therapy can trigger rare but serious hormone problems like adrenal failure, and death risk rises when these issues occur with sev…
Frontiers Apr 16, 2026
Narrative review assesses GLP-1 receptor agonists versus insulin for steroid-induced hyperglycemia and diabetes
Neurology Sys. Review
Narrative review assesses GLP-1 receptor agonists versus insulin for steroid-induced hyperglycemia and diabetes A Common Medication Side Effect May Have a Surprising New Solution
This narrative review evaluates the efficacy and safety of glucocorticosteroid-induced hyperglycemia (SIH) and steroid-induced diabetes (SID…
Doctors are exploring a new way to protect patients from the dangerous blood sugar spikes caused by essential steroid medications.
Frontiers Apr 12, 2026
Plant bioactive polysaccharides show metabolic benefits in umbrella review of systematic reviews
Diabetes & Endocrinology Meta-analysis
Plant bioactive polysaccharides show metabolic benefits in umbrella review of systematic reviews Plant polysaccharides show potential benefits for blood sugar, cholesterol, and gut health
An umbrella review of systematic reviews and meta-analyses found plant bioactive polysaccharides had significant effects on blood lipids and…
Plant polysaccharides linked to better blood sugar, cholesterol, gut health, and weight control, though no effect on blood pressure or liver…
Apr 6, 2026
Marked hyperglycemia linked to higher parenchymal hematoma risk with bridging therapy versus direct EVT in stroke
Neurology RCT
Marked hyperglycemia linked to higher parenchymal hematoma risk with bridging therapy versus direct EVT in stroke High blood sugar linked to bleeding risk after stroke clot removal procedure
A post hoc analysis of 627 patients from the DIRECT-MT trial found that in those with admission glucose >11.1 mmol/L, bridging therapy (alte…
Very high blood sugar levels may increase bleeding risk for stroke patients who receive clot-busting drugs before mechanical clot removal.
Apr 3, 2026

Research across Postprandial Hyperglycemia

Related studies from across the Postprandial Hyperglycemia family.

Resistance exercise after high-carb meal improves postprandial glucose and endothelial function in healthy adults
Physical Medicine & Rehab RCT
Resistance exercise after high-carb meal improves postprandial glucose and endothelial function in healthy adults When should you exercise after a meal to help your blood vessels?
A randomized crossover study in healthy adults found whole-body resistance exercise performed immediately after a high-carbohydrate meal imp…
Doing a full-body workout right after eating helps healthy adults lower blood sugar and improve blood vessel function better than resting or…
Apr 2, 2026

Questions about Hyperglycemia

Does having marked hyperglycemia increase stroke bleeding risk with bridging therapy?

Yes, marked hyperglycemia (glucose >11.1 mmol/L) significantly increases the risk of parenchymal hematoma (bleeding) when bridging therapy is used instead of direct endovascular thrombectomy for stroke.

Full answer →

All Hyperglycemia Articles