Phase 4
N=25
Effectiveness Study of Different Local Anesthetic Mixtures
Pain
Bottom Line
View on ClinicalTrials.gov: NCT01243112 ↗Enrolled (actual)
25
Serious AEs
0.0%
Results posted
Dec 2011
Primary outcome: Primary: Length of Action — 6.63; 7.02; 7.48; 7.16 minutes — p=0.359
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- 1% Lidocaine with Epinephrine (1:100,000) (Drug); 0.25% Bupivacaine with Epinephrine (1:200,000) (Drug); 0.5% Lidocaine, 0.125 Bupivacaine, and epi (1:150,000) (Drug); 1% Lidocaine, 0.5% Bupivacaine, and epinephrine (1:150,000) (Drug)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Scott and White Hospital & Clinic
- Primary completion
- Sep 2010
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Length of Action |
6.63; 7.02; 7.48; 7.16 | 0.359 |
| PRIMARY Onset of Action |
29; 19; 26; 12 | 0.490 |
Summary
Purpose and Background The purpose of this research study is to investigate the benefits of mixing lidocaine and bupivacaine for numbing the skin. Lidocaine and bupivacaine are two commonly used medications to numb the skin for minor procedures. Lidocaine has a faster onset. Bupivacaine has a longer duration. They are often combined with epinephrine to increase the length of action. These medications are used to control pain at the time of the operation and to decrease discomfort immediately afterward. Participating in the study involves injection of local anesthetic containing lidocaine, bupivacaine, and lidocaine and bupivacain with epinephrine at 4 sites on the forearm. Your participation will potentially improve the administration of these medications in persons undergoing a variety of procedures. You will be one of approximately 25 healthy volunteer subjects in this research study.
Eligibility Criteria
Inclusion Criteria
- Age: 18-60
Exclusion Criteria
- Pregnancy
- allergy to local anesthetics
- history of heart disease or diabetes
Data sourced from ClinicalTrials.gov (NCT01243112). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.