N/A
N=90
Resistance Exercise and Knee Osteoarthritis Pain, Functional Impairment and Cartilage Turnover
Knee Osteoarthritis
Bottom Line
View on ClinicalTrials.gov: NCT01245283 ↗Enrolled (actual)
90
Serious AEs
1.1%
Results posted
Oct 2014
Primary outcome: Primary: Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC Score); Change From Baseline at 4 Months — 27.1; 33.3; 28.9; 26.7 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- normal activities and clinical care (Other); Concentric Focused Resistance Exercise (Other); Eccentric Focused Resistance Exercise (Other)
- Age
- Adult, Older Adult · 60+ yrs
- Sex
- All
- Sponsor
- University of Florida
- Primary completion
- Jun 2013
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC Score); Change From Baseline at 4 Months |
27.1; 33.3; 28.9; 26.7; 23; 19.9 | — |
| SECONDARY Six Minute Walk Test; Change From Baseline at 4 Months |
1556; 3600; 4652; 1640; 3496; 4643 | — |
| SECONDARY Chair Rise Time and Stair Climb Time; Change From Baseline at 4 Months |
1.5; 1.2; 1.2; 0.7; 0.8; 1.6 | — |
| SECONDARY Leg Press Test; Change From Baseline at 4 Months |
319; 374; 327; 399; 357; 412 | — |
| SECONDARY Leg Extensions Test; Change From Baseline at 4 Months |
147; 186; 174; 181; 167; 191 | — |
| SECONDARY Leg Curl Test; Change From Baseline at 4 Months |
154; 168; 155; 182; 166; 175 | — |
| SECONDARY Chest Press; Change From Baseline at 4 Months |
170; 184; 167; 199; 170; 174 | — |
| SECONDARY Shoulder Press Test; Change From Baseline at 4 Months |
158; 158; 152; 190; 153; 147 | — |
| SECONDARY Seated Row Test; Change From Baseline at 4 Months |
195; 194; 175; 215; 219; 193 | — |
Summary
The purpose of this study is to determine if a 4 month resistance exercise program can reduce knee osteoarthritis pain functional impairment and cartilage turnover.
Eligibility Criteria
Inclusion Criteria
- Osteoarthritis (OA) of the knee for >6 months
- moderate to severe pain immediately following a 50-foot walk
- knee pain primarily due to tibiofemoral OA and not from patellofemoral OA
- bilateral standing anterior-posterior radiograph demonstrating grade 2 or 3 OA of the target knee
- willing and able to participate in regular exercise for four months
- free from musculoskeletal limitations that would preclude resistance exercise participation
- free of abnormal cardiovascular responses during the screening graded maximal walk test
Exclusion Criteria
- unable to walk
- regular resistance exercise training (>3X week) within the past 6 months
- specific low back pain or acute back injury
- spinal stenosis that precludes walking one block due to neurogenic claudication
- any major injury to either knee within the prior 12 months
- any surgery to either knee within the last 12 months
- lumbar radiculopathy
- vascular claudication
- significant anterior knee pain due to diagnosed isolated patella-femoral syndrome or chondromalacia in either knee
- have had corticosteroid or viscosupplement injections within three months of study participation
- have added new over the counter or prescription pain medication within two months of study participation
Data sourced from ClinicalTrials.gov (NCT01245283). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.