N/A
N=53
The Effect of Neurontin on Pain Management in the Acutely Burned Patient
Pain · Burn Injury
Bottom Line
View on ClinicalTrials.gov: NCT01265056 ↗Enrolled (actual)
53
Serious AEs
0.0%
Results posted
Feb 2013
Primary outcome: Primary: Opioid Consumption Between the Treatment and the Control Groups (Morphine Equivalents) — 7.0; 6.7 morphine equivalents — p=<0.05
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Gabapentin (Drug); Placebo (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Lucy A Wibbenmeyer
- Primary completion
- Sep 2011
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Opioid Consumption Between the Treatment and the Control Groups (Morphine Equivalents) |
7.0; 6.7 | <0.05 sig |
| SECONDARY Psychological Functioning as Evaluated by the Brief Symptom Inventory (BSI) Between Treatment and Placebo Groups |
9; 7.3 | <0.8 |
| SECONDARY Difference in Psychological Outcomes on the Sickness Inventory Profile (SIP) |
34.9; 36.0 | 0.8 |
Summary
Burn patients have extreme pain. Opioids are the main agents used for analgesia. We therefore propose a single center study to fruther assess the efficacy of neuropathic agents in controlling the pain associated with acute thermal injury.
Eligibility Criteria
Inclusion Criteria
- All admitted patients with LOS expected to be > 48 hours (usually burn injury > 5%)
- > 18 years of age
- Thermal injury to skin
Exclusion Criteria
- Prisoners
- Pregnant or nursing women
- Children <18 years of age
- Frostbite or non thermal injury to skin
- Renal insuffiency (creatinine clearance < 60mL/min) or failure (on renal replacement)
- Expected length of stay < 48 hours (this usually includes burn <5%
Data sourced from ClinicalTrials.gov (NCT01265056). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.