Phase 4
Completed N=20
Comparison of Premixed Insulins Aspart 30, Aspart 70 and Aspart on Postprandial Lipids
Source: ClinicalTrials.gov NCT01293396 ↗Enrolled (actual)
20
Serious AEs
0.0%
Results posted
Jun 2021
Primary outcomePrimary: Area Over Basal for Postprandial Glucose From 0 to 600min — 591; 220; 197 mg*/min/dL
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
The aim of the study is to investigate meal-related treatment with either premixed Insulin Aspart 30, Aspart 70 and Aspart with regard to postprandial glucose, triglyceride and free fatty acids excursions after a standard breakfast and lunch.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Area Over Basal for Postprandial Glucose From 0 to 600min |
591; 220; 197 | — |
| PRIMARY Area Over Basal for Postprandial Triglycerides |
484; 358; 412 | — |
| SECONDARY Maximum Glucose Increase |
89.25; 55.95; 60.25 | — |
| SECONDARY Maximum Triglyceride Increase |
484; 358; 412 | — |
| SECONDARY Area Over Basal for Postprandial Insulin |
211.2; 141.2; 128.6 | — |
| SECONDARY Area Over Basal for Postprandial C-peptide |
21.6; 12.8; 13.4 | — |
Eligibility Criteria
Inclusion Criteria
- Type-II Diabetes
- BMI > 27 kg/m2
- age 35 to 75 years
- HbA1c 8.5 %
- Serum Creatinine > 1.7 mg/dl
- Alaninaminotranferase or Aspartataminotransferase > 3x Upper Limit of Normal
- treatment with sulfonylurea or gliptins
- treatment with glitazones
- manifest clinical infections
- treatment with glucocorticoids or antipsychotic drugs
- psychiatric diseases
- alcohol abuse
- myocardial infarction or stroke within the previous 3 months
- surgery within the previous 3 months
Data sourced from ClinicalTrials.gov (NCT01293396). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.