N/A N=37 Basic Science

Does Glaucoma Cause Loss of Brain Function?

Glaucoma

Bottom Line

View on ClinicalTrials.gov: NCT01303939 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Nov 2018

Primary outcome: Primary: Absolute Brain Volume (Size) — 3067; 2302 cubic millimeters (mm3)

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: magnetic resonance imaging (MRI) of the brain (Diagnostic_test)
Age: Adult, Older Adult · 21+ yrs
Sex: All
Sponsor: Wills Eye
Primary completion: Mar 2012

Outcome Measures

Outcome	Result	p-value
PRIMARY Absolute Brain Volume (Size)	3067; 2302	—
SECONDARY Relative Volumes	0.0037; 0.0029	—

Summary

The purpose of the study is to determine if glaucoma is associated with neurodegenerative changes in areas of the brain other than the occipital lobe. This will help guide the direction of further research in the use of neuroprotective agents in preventing or controlling such changes. The final goal is to improve the quality of life for patients with glaucoma.

Eligibility Criteria

Inclusion Criteria

Patients with glaucoma who were participated in other studies Assessment of Ability Related to Vision (AARV) or Assessment of Disability Related to Vision (ADREV) and were found to be outliers in that they have poor performance-based measure scores (≤ 40) despite having midrange visual field scores (mean deviation of -6 to -20).
Age-, gender- and race-matched controls who do not have glaucoma, and who do not have loss of vision for any reason other than cataract or refractive error.

Exclusion Criteria

Patients with any type of neurological disease.
Patients with a cognitive deficit which would affect visual functioning, as revealed by score of less than 25 in the mini mental status examination.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01303939). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.