N/A
N=60
Ischemic Preconditioning in Total Knee Arthroplasty
Total Knee Arthroplasty · Ischemic Preconditioning · Postoperative Pain
Bottom Line
View on ClinicalTrials.gov: NCT01333969 ↗Enrolled (actual)
60
Serious AEs
0.0%
Results posted
Sep 2024
Primary outcome: Primary: Postoperative Pain at Rest and Exercise as Assessed by Visual Analogue Scale (VAS) Scores at 48h After Surgery — 1.75; .71; 3; 1.38 score on a scale — p=.043
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Ischemic Preconditioning (Procedure)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Hospital for Special Surgery, New York
- Primary completion
- Apr 2012
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Postoperative Pain at Rest and Exercise as Assessed by Visual Analogue Scale (VAS) Scores at 48h After Surgery |
1.75; .71; 3; 1.38 | .043 sig |
| SECONDARY Overall Epidural Volume |
140.5; 160.8 | .043 sig |
| SECONDARY Muscle Oxygenation Over Calf at 48h After Surgery |
75; 69 | .584 |
| SECONDARY Levels of Interleukin 6 (IL6) in Drainage Fluid at 24hr Postoperatively |
3.79; 3.57 | 0.763 |
| SECONDARY Periarticular Circumference of the Knee at 6h, 24h, and 48h |
2.3; 1.5 | .602 |
| SECONDARY Hospital Length of Stay |
100.6; 99.4 | .8656 |
| SECONDARY Physical Therapy Milestone |
2.0; 3.0 | .8422 |
| SECONDARY Levels of Leukocytes in Drainage Fluid at 24hr Postoperatively |
2487; 2038 | .526 |
| SECONDARY Levels of TNF-alpha in Drainage Fluid at 24hr Postoperatively |
3.72; 3.76 | .526 |
Summary
The application of a tourniquet for 5 minutes and subsequent reperfusion before actual inflation of the tourniquet for total knee arthroplasty (ischemic preconditioning) decreases the level of local inflammation and therefore postoperative pain in response to reperfusion of the ischemic extremity.
Eligibility Criteria
Inclusion Criteria
- All patients undergoing primary total knee arthroplasty
Exclusion Criteria
- Patients who chronically use narcotics (<1 month).
- Patients with contraindications (severe peripheral vascular disease, presence of femoral-popliteal bypass grafts, etc.) or no plan for tourniquet use as determined by the clinical care team.
- Patients who are on corticosteroids prior to their surgery
Data sourced from ClinicalTrials.gov (NCT01333969). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.