N/A
N=72
Transversus Abdominis Plane (TAP) Block for Postoperative Analgesia After Laparoscopic Colonic Resection
Colonic Cancer · Rectal Cancer · Colonic Diverticulum · Ulcerative Colitis
Bottom Line
View on ClinicalTrials.gov: NCT01339273 ↗Enrolled (actual)
72
Serious AEs
0.0%
Results posted
Feb 2020
Primary outcome: Primary: Morphine Consumption in the First 48hours After the Operation — 47.3; 46.7 mg
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Ultrasound guided Transversus Abdominis Plane (TAP) bock (Procedure); Local anaesthetic infiltration of laparoscopic port sites (Procedure)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Oxford University Hospitals NHS Trust
- Primary completion
- Dec 2013
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Morphine Consumption in the First 48hours After the Operation |
47.3; 46.7 | — |
| SECONDARY Numerical Rating Pain Scores at 48 Hours Postoperatively |
2; 2 | — |
| SECONDARY Nausea Score at 48 Hours Postoperatively |
0; 0 | — |
| SECONDARY Time to First Request for Rescue Analgesia |
— | — |
| SECONDARY Time to Mobilisation |
1; 1 | — |
| SECONDARY Time to Successful Intake of Fluids |
1.5; 2 | — |
| SECONDARY Time to Resumption of Normal Diet |
2; 2.5 | — |
| SECONDARY Time to First Bowel Motion |
2.5; 3 | — |
| SECONDARY Time to First Flatus |
1; 1 | — |
| SECONDARY Time to Medically Fit to Discharge |
4.5; 4.5 | — |
| SECONDARY Total Morphine Consumption at 24hours |
30.9; 31 | — |
| SECONDARY Nausea at 24hours Post Operatively |
0; 0 | — |
| SECONDARY Time to Mobilization |
1; 1 | — |
| SECONDARY Time to Hospital Discharge |
4.5; 4.5 | — |
Summary
Laparoscopic (key-hole) large bowel resection is a minimally invasive procedure when compared to open large bowel resection, but is still associated with a significant amount of pain and discomfort. Analgesia is commonly provided by a multi-modal technique involving varying combinations of paracetamol, Non steroidal anti-inflammatory drugs (NSAIDs), regional analgesia and oral or parenteral opioids. While epidural analgesia is considered the gold standard for open colo-rectal procedures it can be associated with significant complications and may delay hospital discharge in laparoscopic procedures. Opioids are associated with an increased incidence of nausea, vomiting and sedation and reduced bowel motility which can also prolong recovery.
Transversus Abdominis Plane (TAP) block is a technique which numbs the nerves carrying pain sensation from the abdominal wall and provides effective and safe analgesia with minimal systemic side effects. Their perceived benefits are thought to relate to reduced opioid consumption and therefore reduced opioid side effects. The investigators believe ultrasound guided TAP blocks will reduce pain and morphine consumption with a resultant improved patient satisfaction, earlier return of bowel function and earlier hospital discharge.
The key research question the investigators are trying to answer is whether TAP block provide better pain relief than local anaesthetic infiltration of the laparoscopic port sites. Both techniques are currently being used in our hospital and a retrospective audit demonstrated better analgesia and lower consumption of morphine in the TAP block group.The differences were not statistically significant as the number patients in the audit were not large enough.The investigators are hoping that this study will demonstrate that the difference is real by recruiting the necessary number of patients into each group (36 per group)
Eligibility Criteria
Inclusion Criteria
- Participant is willing and able to give informed consent for participation in the study.
- Male or Female, aged 18 years or above.
- Undergoing elective laparoscopic high anterior resection without stoma or laparoscopic right hemicolectomy.
- American Society of Anaesthetists physical status (ASA) 1-3
Exclusion Criteria
- Opioid tolerance
- Chronic abdominal pain
- Allergy/Intolerance: Morphine, local anaesthetics
- BMI>35 Kg/M2
- Previous major abdominal surgery
- High likelihood of conversion to open procedure
- Patients unable to communicate in written and spoken English
- Weight less than 50 kg
Data sourced from ClinicalTrials.gov (NCT01339273). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.