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N/A N=54 Randomized Treatment

Impact of Exercise Training on Pain and Brain Function in Gulf War Veterans

Chronic Musculoskeletal Pain

Bottom Line

View on ClinicalTrials.gov: NCT01350492 ↗
Enrolled (actual)
54
Serious AEs
0.0%
Results posted
Jul 2020
Primary outcome: Primary: Short Form McGill Pain Questionnaire Visual Analog Scale (VAS). — 29.82; 37.08; 30.07; 31.46 units on a scale — p=0.680

Study Design & Population

Study type
Interventional
Phase
N/A
Interventions
Resistance Exercise Training (Behavioral)
Age
Adult, Older Adult · 35+ yrs
Sex
All
Sponsor
VA Office of Research and Development
Primary completion
Jun 2019

Outcome Measures

OutcomeResultp-value
PRIMARY
Short Form McGill Pain Questionnaire Visual Analog Scale (VAS).		 29.82; 37.08; 30.07; 31.46; 30.68; 35.12 0.680
PRIMARY
Physical Component Score (PCS) From the Veterans Rand 36 Item Heath Survey (VR-36).		 43.01; 44.53; 41.82; 43.37; 42.66; 42.92 0.854
PRIMARY
Patients' Global Impression of Change (PGIC).		 3.58; 1.77; 3.67; 2.00; 3.88; 2.05 0.0002 sig
SECONDARY
Physical Activity (Accelerometer)		 261012; 299872; 267376; 321253; 285157; 305315 0.41
SECONDARY
Physical Activity (Self-report)		 4535; 6824; 5856; 4978; 4629; 6491 0.16
SECONDARY
Brain Structure: White Matter Tract Integrity, Operationalized With Fractional Anisotropy (FA) Measures at the Body of the Corpus Callosum.		 0.5263; 0.5213; 0.5256; 0.5213; 0.5261; 0.5224 0.66

Summary

This study is intended to test the influence of weight training on physical symptoms, physical activity and brain structure and function in Gulf War Veterans with chronic widespread muscle pain.

Eligibility Criteria

Inclusion Criteria

  • Veteran of the Persian Gulf War
  • Chronic muscle pain

Exclusion Criteria

  • Regular participation in resistance exercise
  • Color blindness
  • Claustrophobia
  • Medical conditions that could explain the Veteran's pain
  • Use of exclusionary drugs 3 weeks prior to testing
  • Major depressive disorder with melancholic features
  • Substance abuse
  • Schizophrenia
  • Bipolar disorder
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01350492). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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