N/A
N=112
The Effects of Caffeinated Coffee on Intraocular Pressure
Primary Open Angle Glaucoma
Bottom Line
View on ClinicalTrials.gov: NCT01364207 ↗Enrolled (actual)
112
Serious AEs
0.0%
Results posted
Oct 2012
Primary outcome: Primary: Change in Intraocular Pressure at 60 Minutes — 1.51; 0.52 mm Hg
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Caffeinated Coffee (Other); Decaffeinated Coffee (Other)
- Age
- Adult, Older Adult · 40+ yrs
- Sex
- All
- Sponsor
- Massachusetts Eye and Ear Infirmary
- Primary completion
- Aug 2011
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Intraocular Pressure at 60 Minutes |
1.51; 0.52 | — |
| PRIMARY Change in Intraocular Pressure at 90 Minutes |
1.46; 0.40 | — |
Summary
High intraocular pressure (IOP) is a known risk factor for developing primary open-angle glaucoma (POAG). There is controversy in the literature regarding the degree to which caffeine influences IOP, with some studies reporting minimal changes in IOP while others report up to 4 mmHg increases. To date there are no double-masked randomized controlled trials that examine acute caffeinated coffee's effects on IOP in patients with or at risk for primary open-angle glaucoma. The investigators aim to better understand the relationship between acute caffeinated coffee (vs decaffeinate coffee) consumption and IOP in a double-masked, crossover randomized controlled clinical trial.
Eligibility Criteria
Inclusion Criteria
- 40-89 yrs
- POAG for cases or no forms of glaucoma for controls
- Willingness to drink coffee
- Consent signed
Exclusion Criteria
- Age less than 40 or greater than 89 yrs
- all forms of glaucoma other than POAG
- any condition inappropriate for tonometry (ie corneal disease, LASIK)
- unable or unwilling to give consent
- unable or unwilling to drink coffee
- pregnancy
Data sourced from ClinicalTrials.gov (NCT01364207). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.