Phase 4
N=23,687
Continuous Chest Compressions vs AHA Standard CPR of 30:2
Out of Hospital Cardiac Arrest
Bottom Line
View on ClinicalTrials.gov: NCT01372748 ↗Enrolled (actual)
23,687
Serious AEs
0.0%
Results posted
Oct 2016
Primary outcome: Primary: Number of Participants Who Survive From the Time of Cardiac Arrest to Hospital Discharge — 1072; 1127 participants
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- Standard CPR (Other); Continuous chest compressions (Other)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- University of Washington
- Primary completion
- Aug 2015
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants Who Survive From the Time of Cardiac Arrest to Hospital Discharge |
1072; 1127 | — |
| SECONDARY Percentage of Participants Scoring at or Below a 3 on the MRS Scale |
7.7; 7.0 | — |
Summary
The primary aim of the trial is to compare survival to hospital discharge after continuous chest compressions (CCC) versus standard American Heart Association (AHA) recommended cardiopulmonary resuscitation (CPR) with interrupted chest compressions (ICC) in patients with out-of-hospital cardiac arrest (OOHCA). The primary null hypothesis will be that the rate of survival to hospital discharge is not affected by use of continuous compressions with passive or positive pressure ventilation (intervention group) versus CPR with compressions interrupted for ventilation at a ratio of 30:2 (control group).
Eligibility Criteria
Inclusion Criteria
- Age 18 years or more (or local age of consent);
- Initial fire/Emergency Medical Services (EMS) chest compressions provided by Resuscitation Outcomes Consortium (ROC) study participating agency dispatched to the scene;
- Lack of the exclusion criteria below
Exclusion Criteria
- EMS witnessed arrest;
- Written do not attempt resuscitation (DNAR) orders;
- Obvious primary asphyxia or respiratory cause of arrest (drowning, strangulation, hanging)
- Advanced airway placed prior to ROC EMS arrival, or pre-existing tracheostomy
- Traumatic cause (blunt, penetrating, burn) of arrest;
- Known prisoners;
- Known pregnancy;
- Uncontrolled bleeding or exsanguination
- Mechanical compression device used during study-assigned compression cycles
Data sourced from ClinicalTrials.gov (NCT01372748). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.