Phase 4
Completed N=23,687
Continuous Chest Compressions vs AHA Standard CPR of 30:2
Source: ClinicalTrials.gov NCT01372748 ↗Enrolled (actual)
23,687
Serious AEs
0.0%
Results posted
Oct 2016
Primary outcomePrimary: Number of Participants Who Survive From the Time of Cardiac Arrest to Hospital Discharge — 1072; 1127 participants
◆ Published Evidence
Highly cited
305citations · ~28 / year
Trial of Continuous or Interrupted Chest Compressions during CPR.
Summary
The primary aim of the trial is to compare survival to hospital discharge after continuous chest compressions (CCC) versus standard American Heart Association (AHA) recommended cardiopulmonary resuscitation (CPR) with interrupted chest compressions (ICC) in patients with out-of-hospital cardiac arrest (OOHCA). The primary null hypothesis will be that the rate of survival to hospital discharge is not affected by use of continuous compressions with passive or positive pressure ventilation (intervention group) versus CPR with compressions interrupted for ventilation at a ratio of 30:2 (control group).
Linked Publications (2)
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Trial of Continuous or Interrupted Chest Compressions during CPR.
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A randomized trial of continuous versus interrupted chest compressions in out-of-hospital cardiac arrest: rationale for and design of the Resuscitation Outcomes Consortium Continuous Chest Compressions Trial.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants Who Survive From the Time of Cardiac Arrest to Hospital Discharge |
1072; 1127 | — |
| SECONDARY Percentage of Participants Scoring at or Below a 3 on the MRS Scale |
7.7; 7.0 | — |
Eligibility Criteria
Inclusion Criteria
- Age 18 years or more (or local age of consent);
- Initial fire/Emergency Medical Services (EMS) chest compressions provided by Resuscitation Outcomes Consortium (ROC) study participating agency dispatched to the scene;
- Lack of the exclusion criteria below
Exclusion Criteria
- EMS witnessed arrest;
- Written do not attempt resuscitation (DNAR) orders;
- Obvious primary asphyxia or respiratory cause of arrest (drowning, strangulation, hanging)
- Advanced airway placed prior to ROC EMS arrival, or pre-existing tracheostomy
- Traumatic cause (blunt, penetrating, burn) of arrest;
- Known prisoners;
- Known pregnancy;
- Uncontrolled bleeding or exsanguination
- Mechanical compression device used during study-assigned compression cycles
Data sourced from ClinicalTrials.gov (NCT01372748) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.