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Phase 4 N=90 Randomized Triple-blind Treatment

Improvement in Pain,Function and HRQoL ( Health Related Quality of Life) in Subacute Low Back Pain: A Controlled Clinical Trial of Exercise vs NSAIDs (Nonsteroidal Antiinflammatory)

Back Pain Lower Back

Enrolled (actual)
90
Serious AEs
0.0%
Results posted
Apr 2014
Primary outcome: Primary: Visual Analogue Scale of Pain — 47.3; 45.2 units on a scale

Study Design & Population

Study type
Interventional
Phase
Phase 4
Interventions
Exercise program (Other); NSAID (Nonsteroidal anti-inflammatory drugs) (Drug)
Age
Adult · 18+ yrs
Sex
All
Sponsor
Grupo Rehabilitacion en Salud
Primary completion
Oct 2011

Outcome Measures

OutcomeResultp-value
PRIMARY
Visual Analogue Scale of Pain
17.8; 17.5
PRIMARY
Visual Analogue Scale of Pain
17.8; 17.5
PRIMARY
Visual Analogue Scale of Pain
17.8; 17.5
PRIMARY
Visual Analogue Scale of Pain
17.8; 17.5
SECONDARY
Oswestry Disability Index
13.8; 17.2
SECONDARY
Oswestry Disability Index
13.8; 17.2
SECONDARY
Oswestry Disability Index
13.8; 17.2
SECONDARY
Oswestry Disability Index
13.8; 17.2
SECONDARY
Roland-Morris Questionnaire
2.3; 2.5
SECONDARY
Roland-Morris Questionnaire
2.3; 2.5
SECONDARY
Roland-Morris Questionnaire
2.3; 2.5
SECONDARY
Roland-Morris Questionnaire
2.3; 2.5
SECONDARY
Quality of Life, Change in Health
78.0; 70.7
SECONDARY
Quality of Life, Change in Health
78.0; 70.7
SECONDARY
Quality of Life, Change in Health
78.0; 70.7
SECONDARY
Quality of Life, Change in Health
78.0; 70.7
SECONDARY
Quality of Life, Bodily Pain
74.1; 68
SECONDARY
Quality of Life, Bodily Pain
74.1; 68
SECONDARY
Quality of Life, Bodily Pain
74.1; 68
SECONDARY
Quality of Life, Bodily Pain
74.1; 68
SECONDARY
Quality of Life, Emotional Performance.
94.1; 93.9
SECONDARY
Quality of Life, Emotional Performance.
94.1; 93.9
SECONDARY
Quality of Life, Emotional Performance.
94.1; 93.9
SECONDARY
Quality of Life, Emotional Performance.
94.1; 93.9
SECONDARY
Quality of Life, Physical Performance.
84.3; 85.2
SECONDARY
Quality of Life, Physical Performance.
84.3; 85.2
SECONDARY
Quality of Life, Physical Performance.
84.3; 85.2
SECONDARY
Quality of Life, Physical Performance.
84.3; 85.2
SECONDARY
Quality of Life, Physical Function.
84.1; 82.6
SECONDARY
Quality of Life, Physical Function.
84.1; 82.6
SECONDARY
Quality of Life, Physical Function.
84.1; 82.6
SECONDARY
Quality of Life, Physical Function.
84.1; 82.6
SECONDARY
Quality of Life, Social Function.
88.6; 86
SECONDARY
Quality of Life, Social Function.
88.6; 86
SECONDARY
Quality of Life, Social Function.
88.6; 86
SECONDARY
Quality of Life, Social Function.
88.6; 86
SECONDARY
Quality of Life, General Health Perceptions.
73.4; 69.3
SECONDARY
Quality of Life, General Health Perceptions.
73.4; 69.3
SECONDARY
Quality of Life, General Health Perceptions.
73.4; 69.3
SECONDARY
Quality of Life, General Health Perceptions.
73.4; 69.3
SECONDARY
Quality of Life, Mental Health.
78.5; 76.9
SECONDARY
Quality of Life, Mental Health.
78.5; 76.9
SECONDARY
Quality of Life, Mental Health.
78.5; 76.9
SECONDARY
Quality of Life, Mental Health.
78.5; 76.9
SECONDARY
Quality of Life, Vitality.
70.3; 62.8
SECONDARY
Quality of Life, Vitality.
70.3; 62.8
SECONDARY
Quality of Life, Vitality.
70.3; 62.8
SECONDARY
Quality of Life, Vitality.
70.3; 62.8
SECONDARY
PHQ-9 Patient Health Questionnaire (PHQ-9) Depression
2.3; 3.1
SECONDARY
PHQ-9 Patient Health Questionnaire (PHQ-9) Depression
2.3; 3.1
SECONDARY
PHQ-9 Patient Health Questionnaire (PHQ-9) Depression
2.3; 3.1
SECONDARY
PHQ-9 Patient Health Questionnaire (PHQ-9) Depression
2.3; 3.1
SECONDARY
Relapses of Lumbar Pain
5.0; 20.5
SECONDARY
Relapses of Lumbar Pain
5.0; 20.5
SECONDARY
Treatments Associated With Low Back Pain at 6 Months
3; 14
SECONDARY
Missing Workdays
0.2; 0.2
SECONDARY
Missing Workdays
0.2; 0.2
SECONDARY
Missing Workdays
0.2; 0.2
SECONDARY
Missing Workdays
0.2; 0.2
SECONDARY
Medical Consultations.
4; 4
SECONDARY
Medical Consultations.
4; 4
SECONDARY
Medical Consultations.
4; 4

Summary

Our clinical trial has the purpose to evaluate the effectiveness in reducing pain and improving function and quality of life during a 6-months follow-up of a therapeutic exercise program compared to pharmacological treatment with NSAIDs in patients with subacute low back pain attending the physiatrist consultation of several ambulatory health centers in Medellín during the years 2009-2010.

Eligibility Criteria

Inclusion Criteria

  • Patients aged between 18 and 60 years old
  • Subacute low back pain -evolution time more than 4 weeks and less than 3 months.
  • That have social security system
  • Live in the metropolitan area

Exclusion Criteria

  • Antecedents of spinal, pelvis or abdominal trauma
  • Cancer
  • Diabetes mellitus
  • Steroids use
  • Men and Women over 60 years
  • Cauda equine syndrome
  • Women and men with osteoporosis or compression fractures
  • Suspicion of infection.
  • Insidious onset, constitutional symptoms
  • Intravenous drugs abuse
  • HIV
  • Immunosuppression or previous surgery
  • Rheumatic diseases
  • Urinary tract infections
  • Neurological symptoms in lower limbs
  • Mental illness (schizophrenia, bipolar or somatomorphic disorder, major depression)
  • Deformities in the spine (scoliosis greater than 15º)
  • History of peptic acid disease
  • Renal failure
  • Intake of anticoagulants or antiplatelet drugs
  • Allergy to NSAIDs.
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01374269). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.

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