Aspirin Responsiveness in Women With Coronary Artery Disease

Inclusion Criteria

• Able and willing to provide informed consent
• Women at least 45 years old of any race
• Taking 81 mg aspirin daily, for at least one month
• Diagnosed with known or suspected CAD with at least one of the following: angiographic evidence of at least one lesion > 50% stenosis, history of significant elevation of biomarker troponin or CK-MB, or history of ECG changes in at least 2 contiguous leads characterized by either new ST depression > 0.1 mV or transient ( 0.1 mV, coronary artery revascularization either by PCI or CABG

Exclusion Criteria

• 85 years of age
• Clinically unstable: hypotension defined as sustained systolic blood pressure of 30 seconds or associated with symptoms and no ICD, untreated complete heart block or untreated high grade secondary heart block
• Pregnant, planning to become pregnant, or breastfeeding
• Alcohol abuse or illicit drug abuse
• Allergy or intolerance to salicylates and/or excipients including a history of and/or active GI bleed
• Use of NSAIDs within seven days or planned regular use during the study
• Taking HRT or oral contraceptives within the past 30 days or planned use during study
• Use of heparin, warfarin, ADP inhibitors (clopidogrel, prasugrel, or ticlopidine), or glycoprotein IIb/IIa inhibitors within previous 96 hours or planned use during the study
• Use or planned use of any other medications known to interfere with AA-induced platelet function
• Currently participating in another investigational drug or device study
• Survival less than six months