N/A
N=19
High MAP in Septic Shock With Hypertension
Septic Shock
Bottom Line
View on ClinicalTrials.gov: NCT01443494 ↗Enrolled (actual)
19
Serious AEs
0.0%
Results posted
Jun 2014
Primary outcome: Primary: Mean Arterial Pressure — 90 mmHg
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- NE (Other)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Southeast University, China
- Primary completion
- Jun 2012
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mean Arterial Pressure |
90 | — |
| SECONDARY Perfused Vessel Density |
12.08 | — |
Summary
We hypothesized that the increase in MAP from 65 mmHg to patients' usual level improved sublingual microcirculation.
Eligibility Criteria
Inclusion Criteria
- Patients with septic shock for less than 24 hours
- Fluid resuscitation was performed according to the guideline for treating septic shock to maintain the central venous pressure (CVP) for more than 8 mm Hg and central venous oxygen saturation for more than 70%
- Patients requiring norepinephrine (NE) to maintain a MAP of 65 mm Hg. Septic shock patients with fluid resuscitation after CVP > 8mmHg and mean blood pressure > 65 mmHg
Exclusion Criteria
- Pregnancy
- Age < 18 years
- Inability to acquire the usual level of MAP
- Refusal of consent by the patient or relative
- Participation in other trials during the last three months
- Hypertensive patients without hypertension treatment
Data sourced from ClinicalTrials.gov (NCT01443494). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.