N/A Completed N=19 Treatment

High MAP in Septic Shock With Hypertension

Septic Shock

Source: ClinicalTrials.gov NCT01443494 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jun 2014

Primary outcomePrimary: Mean Arterial Pressure — 90 mmHg

Summary

We hypothesized that the increase in MAP from 65 mmHg to patients' usual level improved sublingual microcirculation.

Outcome Measures

Outcome	Result	p-value
PRIMARY Mean Arterial Pressure	90	—
SECONDARY Perfused Vessel Density	12.08	—

Eligibility Criteria

Inclusion Criteria

Patients with septic shock for less than 24 hours
Fluid resuscitation was performed according to the guideline for treating septic shock to maintain the central venous pressure (CVP) for more than 8 mm Hg and central venous oxygen saturation for more than 70%
Patients requiring norepinephrine (NE) to maintain a MAP of 65 mm Hg. Septic shock patients with fluid resuscitation after CVP > 8mmHg and mean blood pressure > 65 mmHg

Exclusion Criteria

Pregnancy
Age < 18 years
Inability to acquire the usual level of MAP
Refusal of consent by the patient or relative
Participation in other trials during the last three months
Hypertensive patients without hypertension treatment

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01443494). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.