Arterial hypotension is a late sign of decompensated shock linked to increased mortality and adverse neurologic outcomes in critically ill children
Low blood pressure in sick kids signals danger and needs careful management
This guideline narrative review addresses arterial hypotension, septic shock, and traumatic brain injury in critically ill infants and child…
Low blood pressure in critically ill children often means shock is worsening. Experts now suggest aiming for targets at least at the 10th pe…
Scoping review on androgen pathways and therapy in adult sepsis and septic shock
Sepsis Patients With Low Testosterone Face Higher Death Risks
This systematic scoping review synthesizes evidence on testosterone levels and androgen-based interventions in adult sepsis or septic shock.…
• Low testosterone strongly links to severe sepsis and death • Helps doctors spot high-risk ICU patients faster • Hormone therapy failed to …
Conservative oxygen targets show no mortality difference in mechanically ventilated critically ill adults
New Oxygen Rules Save Lives Without Extra Risk in ICU
This systematic review and meta-analysis of 20,447 mechanically ventilated critically ill adults in the ICU found no substantial difference …
ICU teams can safely use less oxygen for ventilated patients, new research shows, potentially reducing harm without raising death risk for m…
Polymyxin B haemoadsorption associated with lower mortality in endotoxic septic shock patients
Polymyxin B blood filter cuts death risk in severe septic shock
This phase 3 trial examined polymyxin B haemoadsorption versus standard care in adults with endotoxic septic shock and multiorgan dysfunctio…
A blood filter that removes toxins may cut deaths in adults with severe septic shock, new trial results suggest.
Narrative review of Shenfu Injection for sepsis-induced gastrointestinal injury and septic shock
A Chinese herbal therapy may protect the gut during septic shock
This narrative review examines Shenfu Injection for sepsis-induced acute gastrointestinal injury and septic shock.
A traditional Chinese herbal blend may help protect the gut during septic shock, offering a new angle on a deadly complication that often go…
Large language models show varying accuracy for data extraction in sepsis guidelines
AI models show promise for extracting sepsis study data
This study evaluated the performance of large language models, including ChatGPT-4o, Claude 3 Sonnet, and Gemini 1.5 Pro, for data extractio…
New tests show AI can help pull patient details from medical papers, but extracting clinical results remains a major challenge.
Non-invasive ultrasound defines snuffbox artery RI and PI reference ranges in healthy volunteers versus ICU patients with septic shock or hypertension
New blood flow numbers reveal hidden risks in shock patients
This prospective observational cohort study included 91 healthy volunteers and 55 ICU patients at a 4,900-bed tertiary care hospital in Chin…
A simple finger test now shows hidden blood flow problems that standard checks miss in sick patients.
Retrospective cohort study links pulse pressure levels to 28-day mortality in septic shock patients
New Blood Pressure Target Could Save Septic Shock Patients
This retrospective cohort study examined septic shock patients across two settings to assess pulse pressure levels during the first 24 h in …
A new study suggests a specific blood pressure range improves survival for people in septic shock.
Seraph Microbind filter used in a 7-year-old with refractory septic shock and invasive Streptococcus pyogenes infection
New Filter May Save Children in Life-Threatening Shock
This single case report describes a previously healthy 7-year-old girl with refractory septic shock and invasive Streptococcus pyogenes infe…
This device offers a new rescue option for kids whose bodies shut down from infection.
Thiamin supplementation associated with reduced mortality in septic shock patients
Thiamin Cuts Death Risk in Sepsis Shock
This meta-analysis of randomized controlled trials evaluated thiamin supplementation versus placebo or blank controls in patients with septi…
A common vitamin called thiamin lowers death risk and kidney failure needs for patients in septic shock, offering new hope for severe infect…
CytoSorb hemoadsorption shows no benefit and potential harm in small septic shock trial
A Promising Sepsis Treatment May Do More Harm Than Good
A single-center RCT of 31 adults with septic shock and high IL-6 found no significant difference in cumulative norepinephrine dose (primary …
A high-tech blood filter for sepsis failed to help patients and may have worsened early survival rates in a new study.
Socioeconomic factors associated with increased mortality in adults with sepsis or septic shock
Study finds poverty and lack of insurance linked to higher death rates from sepsis
A systematic review and meta-analysis of 13 observational studies involving 3,951,677 adults with sepsis or septic shock found that several …
Poverty and lack of private insurance are linked to higher death rates from sepsis, affecting nearly 4 million adults in a major review.
Questions about Septic Shock
Do doctors need to give extra oxygen to patients with septic shock?
Yes, doctors often give extra oxygen to septic shock patients, but recent evidence shows conservative oxygen targets (SpO2 88-94%) are as safe as liberal targets, with no difference in mortality.
Full answer →Is it better to have high or low pulse pressure when you have septic shock?
In septic shock, a pulse pressure between 40-70 mmHg during the first 24 hours is linked to lower 28-day mortality; both very low and very high pulse pressure are associated with worse outcomes.
Full answer →All Septic Shock Articles
- Arterial hypotension is a late sign of decompensated shock linked to increased mortality and adverse neurologic outcomes in critically ill children
- Scoping review on androgen pathways and therapy in adult sepsis and septic shock
- Conservative oxygen targets show no mortality difference in mechanically ventilated critically ill adults
- Polymyxin B haemoadsorption associated with lower mortality in endotoxic septic shock patients
- Narrative review of Shenfu Injection for sepsis-induced gastrointestinal injury and septic shock
- Large language models show varying accuracy for data extraction in sepsis guidelines
- Non-invasive ultrasound defines snuffbox artery RI and PI reference ranges in healthy volunteers versus ICU patients with septic shock or hypertension
- Retrospective cohort study links pulse pressure levels to 28-day mortality in septic shock patients
- Seraph Microbind filter used in a 7-year-old with refractory septic shock and invasive Streptococcus pyogenes infection
- Thiamin supplementation associated with reduced mortality in septic shock patients
- CytoSorb hemoadsorption shows no benefit and potential harm in small septic shock trial
- Neostigmine infusion in septic shock linked to lower TNF-alpha and 28-day mortality in single-center RCT
- Socioeconomic factors associated with increased mortality in adults with sepsis or septic shock
- Corticosteroids in cirrhotic shock show no mortality benefit but increase bleeding and organ failure risk
- Network meta-analysis finds PMX and HA 330 blood purification may reduce mortality in severe septic shock
- VR and in-person sepsis simulation show similar skill outcomes in medical student pilot study
- Balanced salt solution in pediatric septic shock linked to lower AKI and RRT rates versus normal saline