N/A
N=99
Exercise Trial in Chronic Kidney Disease
Chronic Kidney Disease
Bottom Line
View on ClinicalTrials.gov: NCT01462097 ↗Enrolled (actual)
99
Serious AEs
55.6%
Results posted
Jan 2023
Primary outcome: Primary: Change in Peak Aerobic Capacity — 17.1; 16.8; 17.9; 15.9 ml/kg/min
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Aerobic exercise training (Behavioral); Health Education (Behavioral)
- Age
- Adult, Older Adult · 60+ yrs
- Sex
- All
- Sponsor
- University of Maryland, Baltimore
- Primary completion
- Oct 2017
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Change in Peak Aerobic Capacity |
17.1; 16.8; 17.9; 15.9; 18.7; 17.2 | — |
| PRIMARY Change in 6 Minute Walk |
1298; 1251; 1649; 1247; 1453; 1284 | — |
| SECONDARY Change in Physical Function |
8.2; 8.6; 8.0; 9.3; 8.3; 9.0 | — |
| SECONDARY Number With Short Physical Performance Battery (SPPB) Score <10 (Out of 12 Maximum) |
19; 19; 9; 15; 9; 16 | — |
Summary
Chronic Kidney Disease (CKD) is exceedingly common in older adults, in whom it is associated with impairment in cognition and physical function. The purpose of this study is to test the effects of 12 months of aerobic and resistance exercise training compared to health education on cognitive and physical performance in 120 older adults with CKD not requiring dialysis. The results of this study will be essential for demonstrating the effectiveness of exercise in improving function and ultimately preventing disability in this high-risk population of older adults.
Eligibility Criteria
Inclusion Criteria
- Stage 3-4 Chronic kidney disease (estimated Glomerular Filtration Rate 15-45)
- Age 60 to 85
- English Speaking
Exclusion Criteria
- Dementia or cognitive impairment
- Renal transplant
- New York Heart Association class 3-4 heart failure
- Severe Chronic Lung Disease
- Unstable angina or coronary revascularization within the last 3 months
- Orthopedic problems that would preclude aerobic exercise training
- Known, untreated infection
- Disabling arthritis
- Uncontrolled arrhythmia
- More than 14 alcoholic drinks per week
Data sourced from ClinicalTrials.gov (NCT01462097). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.