Phase 1
N=40
A First-in-Human Study of LY3009385 in Healthy Participants
Diabetes Mellitus, Type 2
Bottom Line
View on ClinicalTrials.gov: NCT01477567 ↗Enrolled (actual)
40
Serious AEs
0.0%
Results posted
Oct 2014
Primary outcome: Primary: Number of Participants With One or More Drug-related Adverse Events (AEs) or Any Serious AEs — 1; 1; 1; 2 participants
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 1
- Interventions
- LY3009385 (Drug); Placebo (Drug)
- Age
- Adult, Older Adult · 21+ yrs
- Sex
- All
- Sponsor
- Eli Lilly and Company
- Primary completion
- Mar 2012
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants With One or More Drug-related Adverse Events (AEs) or Any Serious AEs |
1; 1; 1; 2; 5; 5 | — |
| SECONDARY Pharmacokinetics: Area Under the Concentration Curve (AUC) of LY3009385 |
4.81; 9.49; 53.1; 214; 757; 1670 | — |
| SECONDARY Pharmacokinetics: Maximum Concentration (Cmax) |
14.1; 51.9; 180; 847; 2030; 4810 | — |
| SECONDARY Change in Level of Blood Glucose Before and After a Standard Meal |
76.54; -45.35; -8.44; -14.50; -31.33; -108.93 | — |
| SECONDARY Change in Level of C-peptide Before and After a Standard Meal |
932.50; 2235.08; 982.50; 1510.58; 640.25; -116.50 | — |
| SECONDARY Change in Level of Glucagon Before and After a Standard Meal |
0.93; -1.05; 0.68; 0.68; 0.48 | — |
| SECONDARY Number of Participants Forming Antibody to LY3009385 |
1; 2; 2; 2; 2; 0 | — |
Summary
The main purpose of this study is to determine the safety of LY3009385 in healthy participants. The study drug is given as a single dose, by injections under the skin. Side effects will be documented. This study is approximately 28 days not including screening. Screening is required within 28 days prior to the start of the study.
Eligibility Criteria
Inclusion Criteria
- Are a healthy male or a female who cannot become pregnant
- Have a body mass index (BMI) of 18.5 to 32.0 kilograms per meter squared (kg/m^2) at screening
- Have blood pressure, pulse rate, as well as blood and urine laboratory test results acceptable for the study
- Have veins suitable for easy blood collection
- Are reliable and willing to be available for the whole study and be willing to follow study procedures
- Have given consent to participate in this study
Exclusion Criteria
- Are currently participating in or were in another new drug or device or in any medical research study in the last 30 days
- Currently have or used to have allergies or other health problems or laboratory test results that in the opinion of the doctor, could make it unsafe for the participant to participate, or interfere with understanding the results of this study
- Have received live vaccine(s) within 1 month of screening, or intend to during the study
- Have received treatment with biologic agents (such as monoclonal antibodies) within 3 months or 5 half-lives (whichever is longer) prior to dosing
- Have a weakened immune system
- Have previously completed or withdrawn from this study
- Have illnesses or conditions that may increase risk when taking the study medication or interfere with the interpretation of data in this study
- Have electrocardiogram (ECG) readings that are not suitable for the study
- Are using or intend to use over-the-counter medications or prescription medications within 7 and 14 days (respectively) from the start of the first study dosing until end of the study
- Have a history of drug or alcohol abuse
- Are infected with hepatitis B
- Are infected with human immunodeficiency virus (HIV)
- Have donated 450 milliliters (mL) or more of blood in the last 3 months or made any blood donation within the last month
- Have a regular alcohol intake greater than 21 units per week (males) and 14 units per week (females) or are unwilling to abstain from alcohol 24 hours before dosing until the completion of each inpatient study period
- Smoke more than 10 cigarettes per day or are unable or unwilling to refrain from smoking while at the clinic
- Are unwilling or unable to follow dietary requirements/restrictions for the study and only consume only the meals provided during inpatient stays at the clinical research unit
- Are deemed unsuitable to participate by the study doctor for any other reasons
Data sourced from ClinicalTrials.gov (NCT01477567). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.