Phase 2 Completed N=40 Randomized Triple-blind Treatment

Effects of Transcranial Direct Current Stimulation on the Apathy of Alzheimer's Disease

Apathy · Alzheimer's Disease

Source: ClinicalTrials.gov NCT01481558 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jan 2014

Primary outcomePrimary: Apathy Symptoms — -2.05; -1.95 units on a scale — p=0.55

Summary

This is a phase 2 double-blind, randomized, sham-controlled study to investigate the effects of repeated transcranial direct current stimulation for the treatment of apathy in moderate Alzheimer's Disease in patients selected from an outpatient clinics in São Paulo, Brazil.

Outcome Measures

Outcome	Result	p-value
PRIMARY Apathy Symptoms	-2.05; -1.95	0.55

Eligibility Criteria

Inclusion criteria

Dementia defined by DSM-IV (Diagnostic and Statistical Manual version IV)
Possible Alzheimer's Disease defined by NINCDS-ADRDA (National Institute for Neurological and Communicative Disorders and Stroke and the Alzheimer's Disease and Related Disorders Association)
Mini Mental State Examination scores from 10 to 20
Apathy defined by a score equal or higher to 14 in Apathy Scale

Exclusion criteria

Clinical instability
Epilepsy
Metallic clip in the head
Use of alcohol and psychotropic drugs

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01481558). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.