N/A N=37 Randomized Single-blind Treatment

Effectiveness of Cognitive Remediation in a Supported Education Setting

Psychosis

Bottom Line

View on ClinicalTrials.gov: NCT01492439 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jun 2014

Primary outcome: Primary: Completion of Academic Semesters — 1.95; 1.67; 1.89; 1.67 Courses completed — p=0.029

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Cognitive Remediation (Behavioral); Supported Education (Behavioral)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Centre for Addiction and Mental Health
Primary completion: Jul 2013

Outcome Measures

Outcome	Result	p-value
PRIMARY Completion of Academic Semesters	1.95; 1.67; 1.89; 1.67	0.029 sig
SECONDARY Positive and Negative Symptoms Scale (PANSS) Score at 3 Months	13.22; 13.90; 12.83; 14.31; 27.89; 29.23	0.247
SECONDARY The Rosenberg Self-Esteem Scale Score at 3 Months	21.72; 15.31	0.000 sig
SECONDARY The Positive and Negative Symptoms Scale (PANSS) Score at 6 Months	14.40; 13.44; 11.53; 17.44; 26.20; 28.44	0.950
SECONDARY The Rosenberg Self-Esteem Scale Score at 6 Months	21.53; 16.00	0.008 sig
SECONDARY The California Verbal Learning Test at 3 Months	5.83; 5.23; 28.28; 26.08; 7.22; 6.92	0.314
SECONDARY The California Verbal Learning Test at 6 Months	6.00; 5.00; 28.60; 26.44; 7.40; 7.44	0.139
SECONDARY The Trail Making Test Part A at 3 Months	33.89; 27.08	0.391
SECONDARY The Trail Making Test Part A at 6 Months	33.20; 31.00	0.958
SECONDARY The Digit Span Subtest of the Wechsler Adult Intelligence Scale - III at 3 Months	9.05; 9.07; 5.22; 5.23; 14.28; 14.31	0.754
SECONDARY The Digit Span Subtest of the Wechsler Adult Intelligence Scale - III at 6 Months	9.73; 9.67; 6.60; 5.78; 16.33; 15.22	0.802
SECONDARY The Trail Making Test Part B at 3 Months	104.11; 81.31	0.267
SECONDARY The Trail Making Part B at 6 Months	88.58; 70.22	0.527
SECONDARY The Wisconsin Card Sorting Test at 3 Months	40.00; 44.38	0.612
SECONDARY The Wisconsin Card Sorting Test at 3 Months	40.00; 44.38	0.612
SECONDARY The Wisconsin Card Sorting Task at 6 Months	39.87; 41.33	0.843
SECONDARY The Wisconsin Card Sorting Task at 6 Months	39.87; 41.33	0.843
SECONDARY The Digit Vigilance Test at 3 Months	446.11; 366.61	0.004 sig
SECONDARY The Digit Vigilance Test at 6 Months	409.93; 433.33	0.468

Summary

The purpose of this study is to determine whether cognitive remediation as an adjunct to supported education, will result in improved cognitive functioning, symptoms, and performance in academic domains for persons with psychosis compared to supported education given alone.

Eligibility Criteria

Inclusion Criteria

Enrollment in the George Brown Redirection Through Education program.
A DSM-IV chart diagnosis of schizophrenia or other psychotic condition
Stable use of medications for at least 3 months without plans of changing medications.
Proficiency in English.

Exclusion Criteria

a psychiatric history of mental retardation, brain injury, or other neurological condition.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01492439). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.