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Psychiatry
Meta-analysis
Meta-analysis on psychological interventions and early psychosis care for depression and psychosis
Psychological interventions cut major depression risk by 43% after treatment
This meta-analysis synthesizes evidence on psychological interventions for subclinical depression and early intervention for first-episode p…
Early psychological help for subclinical symptoms lowers major depression risk by 43% after treatment and 33% a year later, a meta-analysis …
Frontiers
Apr 22, 2026
Psychiatry
Cohort
Observational cohort links symptom severity subgroups to poorer functioning and brain volume in psychosis and depression risk.
Severe Mental Symptoms Share Hidden Common Cause
This observational cohort study stratified 749 participants into transdiagnostic symptom severity subgroups. Symptom severity was associated…
This could explain why different mental illnesses feel so similar in early stages.
medRxiv
Apr 22, 2026
Psychiatry
RCT
Aripiprazole linked to less insight improvement than dopamine antagonists in schizophrenia trial
Can reducing symptoms help people with schizophrenia gain insight into their illness?
A 6-week RCT of 144 schizophrenia spectrum disorder patients found symptom reduction was associated with improved clinical insight. Patients…
Reducing symptoms helps people with schizophrenia gain insight into their illness, but early improvement in hallucinations and delusions mat…
Apr 7, 2026
Psychiatry
Phase III
Planned trial compares injectable antipsychotics to usual care for psychosis with stimulant use
Hong Kong trial planned to test antipsychotic injections for substance use with psychosis
A trial record describes a planned phase 2/3 study of 165 individuals in Hong Kong with substance use disorders and psychosis. The study wil…
Hong Kong researchers plan a trial to test long-acting antipsychotic injections for people with substance use disorders and psychosis.
CT.gov
Apr 3, 2026