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Home › Conditions › Psychosis

Psychosis

Subtypes of Psychosis

First-Episode Psychosis 8 Psychotic disorders 8 Clinical High-Risk for Psychosis 2 Schizoaffective disorder 2 Medically-associated psychosis 1 Substance-/medication-induced psychosis 1

25 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Psychosis

34 trials tracked for Psychosis: 4 in phase 3 or 4.

34Trials tracked
4Phase 3 & 4
0Recruiting
0With published results
Phase distribution
Phase 4 1 Phase 3 3 Phase 2 4 Phase 1 2 Other / NA 24
  1. Phase 4 Treatment of Alcohol Dependence and Comorbid Bipolar Disorder Completed
  2. Phase 3 Open-label Ziprasidone Study for Psychosis Treatment in Adolescents Completed
  3. Phase 3 Aspirin in Young Psychotic Patients Completed
  4. Phase 3 Study of Asenapine in Elderly Subjects With Psychosis (A7501021)(P05717) Completed
  5. Phase 2 Effects of Intranasal Insulin on Neuroimaging Markers and Cognition in Patients With Psychotic Disorders Completed
  6. Phase 2 Levetiracetam in Early Psychosis Completed
Show 28 more trials
  1. Phase 2 Treatment of Psychosis and Agitation in Alzheimer's Disease Completed
  2. Phase 2 Curcumin as a Novel Treatment to Improve Cognitive Dysfunction in Schizophrenia Completed
  3. Phase 1 Developing Clinical Tools to Communicate Genetic Risk for Individuals Who Are Clinical High Risk for Psychosis Completed
  4. Phase 1 NAPLS Omega-3 Fatty Acid Versus Placebo Study Completed
  5. N/A Effect Evaluation of Individual Placement and Support (IPS) Completed
  6. N/A Mindfulness, Group Therapy and Psychosis; Training Decreases Anxiety and Depression Completed
  7. N/A Prefrontal Cortical Engagement Through Non-Invasive Brain Stimulation in Schizophrenia Completed
  8. N/A Vitamin D Supplementation in Psychiatric Illnesses Completed
  9. N/A Treatment to Enhance Cognition in Bipolar Disorder Completed
  10. N/A Social Cognition Intervention Completed
  11. N/A Feasibility of an Early Detection Program for Early Psychosis on a College Campus Completed
  12. N/A Effectiveness of Cognitive Remediation in a Supported Education Setting Completed
  13. N/A Community Reinforcement and Family Training for Early Psychosis (CRAFT-EP) and Substance Use: A Pilot Study Completed
  14. N/A Testing the Effectiveness of The Welcome Basket Intervention Completed
  15. N/A CBT-I for Psychosis: Guidelines, Preliminary Efficacy, and Functional Outcomes Completed
  16. N/A Minnesota Community-Based Cognitive Training in Early Psychosis Completed
  17. N/A USS Training to Improve Social Function in People With Psychosis Completed
  18. N/A The Family Cognitive Adaptation Training Manual: A Test of Effectiveness Completed
  19. N/A mHealth for Psychosis Help-seeking Completed
  20. N/A The Relationship Between Autobiographical Memory and Motivation Completed
  21. N/A Improving Hallucinations by Targeting the rSTS With tES Completed
  22. N/A CBTpro: Scaling up CBT for Psychosis Using Simulated Patients and Spoken Language Technologies Completed
  23. N/A Cognitive Behavioral Suicide Prevention for Psychosis: Aim 1 Completed
  24. N/A Families With Substance Use and Psychosis: A Pilot Study Completed
  25. N/A Pilot Study of Motivational Interviewing for Loved Ones Completed
  26. N/A Improving Adherence to Cognitive Rehabilitation Completed
  27. N/A Cognitive Behavioral Suicide Prevention for Psychosis: Aim 2 Completed
  28. N/A Transcranial Direct Current Stimulation and Cognitive Remediation Therapy for Psychosis Completed

Showing the 34 most-cited and recently-updated of 34 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Psychosis: what the trials found

Pharmacological management of psychosis includes the use of Ziprasidone 6 and Asenapine 7.

Lamotrigine was evaluated for its impact on alcohol use in patients with psychosis; results showed a mean of 78.7% to 80.1% days abstinent from alcohol, with MADRS scores ranging from 6.93 to 12.05 4.

Aspirin was studied for its effect on psychopathology (PANSS) and cognitive measures (MoCA), but did not show statistically significant differences in these outcomes (p=0.133 and p=1.607, respectively) 5.

Recent results — preliminary, needs further review

  • CBTpro was associated with specific mean scores on the Revised Green Paranoid Thoughts Scale (R-GPTS) and Sheehan Disability Scale (SDS) 2.
  • CRAFT-EP significantly improved family wellbeing by reducing depression (p=0.026) and anxiety (p=0.003), though it did not reach statistical significance for improving relationship scores (p=0.091) 3.
  • Guided Autobiographical Memory Recall was associated with post-intervention motivation scores of 81.01 and 72.89 16.
  • Other recent interventions include Cognitive Behavioral Suicide Prevention for psychosis (CBSPp) 1, Transcranial Electrical Stimulation 14, and the NORTH "Full" protocol 15.

For the clinician treating this condition

  • Ziprasidone and Asenapine are established pharmacological options for psychosis management.
  • Lamotrigine has been shown to correlate with specific alcohol abstinence rates in this population.
  • CRAFT-EP is an effective intervention for improving family members' anxiety and depression levels.

AI synthesis of 10 cited trials, updated Jun 21, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
Serotonergic antidepressants and prolactin-elevating antipsychotics are associated with higher burdens of sexual dysfunction
Psychiatry Sys. Review
Serotonergic antidepressants and prolactin-elevating antipsychotics are associated with higher burdens of sexual dysfunction Certain medications for depression and psychosis can cause sexual issues
This narrative review examines the impact of antidepressants and antipsychotics on sexual dysfunction in patients with depressive and psycho…
Some common treatments for mood and psychotic disorders may impact a patient's sex life, quality of life, and their ability to stay on medic…
Frontiers Jul 21, 2026
Childhood adversity linked to reduced prefrontal gray matter in psychotic and bipolar disorders
Psychiatry Meta-analysis
Childhood adversity linked to reduced prefrontal gray matter in psychotic and bipolar disorders Childhood adversity linked to brain changes in psychotic and bipolar disorders
This meta-analysis of 3056 participants found significant negative associations between childhood adversity and gray matter volume in prefro…
New data shows that childhood trauma is linked to specific shrinkage in parts of the brain for people with psychotic and bipolar disorders.
medRxiv Jul 20, 2026
Psychosis symptoms in youth linked to 2-fold higher risk of later mental health disorders
Psychiatry Meta-analysis
Psychosis symptoms in youth linked to 2-fold higher risk of later mental health disorders Psychosis symptoms in youth linked to later mental health disorders
This meta-analysis of studies in children and youth under 25 without baseline mental health diagnoses found that psychosis spectrum symptoms…
Children and teens with mild psychosis symptoms face double the risk of later mental health disorders, a new analysis finds.
medRxiv Jul 16, 2026
New 27-item screening tool developed for mental disorders in Indonesian prisons
Psychiatry Guideline
New 27-item screening tool developed for mental disorders in Indonesian prisons New screening tool helps identify mental health issues in prisons
This guideline describes the development of a 27-item, eight-domain screening tool for mental disorders among inmates in Indonesia, based on…
A new 27-item tool aims to help identify depression, anxiety, and other mental disorders among people in Indonesian prison systems.
Frontiers Jul 14, 2026
Resting-state qEEG identifies distinct neurophysiological signatures in chronic schizophrenia compared to first-episode psychosis
Psychiatry Meta-analysis
Resting-state qEEG identifies distinct neurophysiological signatures in chronic schizophrenia compared to first-episode psychosis Brain wave patterns help distinguish schizophrenia from early psychosis
This systematic review of 19 studies evaluates resting-state quantitative electroencephalography (qEEG) as a biomarker for schizophrenia and…
New research shows that specific brain wave changes can tell the difference between chronic schizophrenia and first-episode psychosis.
Frontiers Jun 13, 2026
High-potency cannabis products are consistently linked to increased risks of psychosis and anxiety symptoms
Psychiatry Sys. Review
High-potency cannabis products are consistently linked to increased risks of psychosis and anxiety symptoms High Potency Cannabis Linked to Increased Risk of Psychosis
This narrative review examines the mental health consequences of contemporary high-potency cannabis use in Europe. The authors synthesize ev…
New research highlights a consistent link between high-potency cannabis products and increased risks of psychosis, anxiety, and panic sympto…
Frontiers Jun 10, 2026
Exposure to T gondii linked to small psychiatric risks but causality remains uncertain in current reviews
Psychiatry Sys. Review
Exposure to T gondii linked to small psychiatric risks but causality remains uncertain in current reviews Cat owners might face higher risks for certain mental health struggles
Current reviews suggest small-to-moderate associations between T. gondii exposure and conditions like schizophrenia, yet evidence for cat ow…
New research suggests a hidden parasite from cats might slightly increase the risk of mental health issues like schizophrenia and anxiety in…
Frontiers May 13, 2026
Psychosis Prevalence in SLE Patients: Meta-Analysis of 31,495 Adults
Rheumatology Meta-analysis
Psychosis Prevalence in SLE Patients: Meta-Analysis of 31,495 Adults Lupus psychosis risk is higher than doctors thought
A meta-analysis of 31,495 SLE patients found psychosis prevalence of 4.5% overall and 20.5% in NPSLE, highlighting the need for clinical vig…
Many people with lupus may face a higher risk of psychosis than previously believed, and a key antibody could help spot those most at risk.
May 3, 2026
Systematic review and meta-analysis finds 50% prevalence of antipsychotic polypharmacy in MENAT/EMRO countries
Psychiatry Meta-analysis
Systematic review and meta-analysis finds 50% prevalence of antipsychotic polypharmacy in MENAT/EMRO countries Half of Schizophrenia Patients Take Multiple Drugs at Once
This systematic review and meta-analysis of 17 studies (6,053 individuals) from MENAT/EMRO countries found a pooled prevalence of antipsycho…
New data reveals half of patients with schizophrenia in the Middle East take multiple antipsychotic drugs at once.
Frontiers Apr 29, 2026
Observational study identifies sensory perception differences in schizophrenia and first-episode psychosis
Psychiatry
Observational study identifies sensory perception differences in schizophrenia and first-episode psychosis Simple tests reveal unique sensory signs for early psychosis types
This observational study investigated psychophysical differences in pictorial size perception and auditory discomfort among patients with sc…
New low-cost tests can spot unique sensory changes that help doctors tell schizophrenia apart from bipolar disorder in early psychosis cases…
medRxiv Apr 28, 2026
Systematic review of dance/movement therapy for psychotic and eating disorders
Psychiatry Meta-analysis
Systematic review of dance/movement therapy for psychotic and eating disorders Dance therapy shows promise for teens and adults with mental health challenges
This systematic review of 12 studies examined dance/movement therapy as an adjunctive intervention for adolescents or adults with psychotic …
A review of 12 studies suggests dance and movement therapy can help people with psychotic or eating disorders feel more connected and emotio…
Frontiers Apr 24, 2026
Meta-analysis on psychological interventions and early psychosis care for depression and psychosis
Psychiatry Meta-analysis
Meta-analysis on psychological interventions and early psychosis care for depression and psychosis Psychological interventions cut major depression risk by 43% after treatment
This meta-analysis synthesizes evidence on psychological interventions for subclinical depression and early intervention for first-episode p…
Early psychological help for subclinical symptoms lowers major depression risk by 43% after treatment and 33% a year later, a meta-analysis …
Frontiers Apr 22, 2026

Questions about Psychosis

Can psychological therapy help with depression and early psychosis?

Yes, psychological therapy can help with depression and early psychosis, reducing hospitalizations and improving outcomes.

Full answer →
What is the overall chance of having psychosis if I have lupus?

Based on a large meta-analysis, about 4.5% of adults with lupus experience psychosis, with higher risk in those with active disease or certain antibodies.

Full answer →

All Psychosis Articles