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N/A Completed N=45 Randomized Single-blind Supportive Care

Computer Training Program for Younger Patients With a Brain Tumor Who Underwent Radiation Therapy

Source: ClinicalTrials.gov NCT01503086 ↗
Enrolled (actual)
45
Serious AEs
Results posted
Dec 2025
Primary outcomePrimary: Intervention Compliance — 0.39; 0.50 Proportion of Participants

Summary

This randomized clinical trial studies how well an adaptive computerized cognitive training program works compared to a non-adaptive computerized cognitive training program in treating younger patients with brain tumor who underwent radiation therapy. Providing a computer training program may improve the well-being and quality of life of patients with cognitive (physical and mental) function difficulties caused by radiation therapy to the brain.

Outcome Measures

OutcomeResultp-value
PRIMARY
Intervention Compliance
0.39; 0.50

Eligibility Criteria

Inclusion Criteria

  • Patient must be newly diagnosed or relapsed/progressed with a brain tumor that has not previously been treated with CRT
  • Note: COG therapeutic study participation is not required for ACCL10P1 enrollment
  • Patient enrollment must occur within 4 calendar months following completion of CRT
  • Reminder: after patient enrollment, baseline testing followed by randomization must occur within 2-4 months after completion of CRT
  • The patient must have an identified caregiver who is willing and able to oversee the training practice during the intervention period (ie, for 5-9 weeks starting approximately 3 months after completion of CRT)
  • The patient must have access to a telephone and phone number where they can be reached
  • The patient and caregiver must have reading, speaking and listening comprehension of English
  • All patients and/or their parents or legal guardians must sign a written informed consent (patient assent is also recommended when applicable according to each institution's policy)
  • All institutional, Food and Drug Administration (FDA), and National Cancer Institute (NCI) requirements for human studies must be met

Exclusion Criteria

  • Patients with pontine glioma are not eligible
  • Patients with an estimated survival of less than one year are not eligible
  • Patients with a history of traumatic brain injury prior to tumor diagnosis are not eligible
  • Patients with a motor, visual, or auditory handicap that prevents computer use (e.g., unresolved posterior fossa syndrome) are not eligible to participate in this trial
  • Patients with full-scale intelligence quotient (IQ) < 70 per previous testing OR existing diagnosis of/educational classification as a student with an intellectual disability are not eligible
View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01503086). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.

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