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Home › Conditions › Brain Cancer

Brain Cancer

0 published articles · Updated continuously

Clinical Trial Landscape

Clinical Trials for Brain Cancer

233 trials tracked for Brain Cancer: 18 in phase 3 or 4 and 6 with published results. The most-cited published study has 1183 citations.

233Trials tracked
18Phase 3 & 4
0Recruiting
6With published results
Phase distribution
Phase 4 6 Phase 3 12 Phase 2 167 Phase 1 21 Other / NA 27
  1. Phase 3 Radiation Therapy With or Without Temozolomide in Treating Older Patients With Newly Diagnosed Glioblastoma Multiforme Completed · 1,183 cited
  2. Phase 3 An Investigational Immuno-therapy Study of Temozolomide Plus Radiation Therapy With Nivolumab or Placebo, for Newly Diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer) Completed · 513 cited
  3. Phase 3 An Investigational Immuno-therapy Study of Nivolumab Compared to Temozolomide, Each Given With Radiation Therapy, for Newly-diagnosed Patients With Glioblastoma (GBM, a Malignant Brain Cancer) Completed · 498 cited
  4. Phase 3 Radiation Therapy Combined With Chemotherapy in Treating Patients With Anaplastic Astrocytoma or Mixed Gliomas Completed · 26 cited
  5. Phase 3 Hypovitaminosis D in Neurocritical Patients Completed · 22 cited
  6. Phase 4 Single Dose Tramadol Effect on Extubation Response and Quality of Emergence Post-supratentorial Intracranial Surgery Completed
Show 44 more trials
  1. Phase 4 Efficacy Evaluation of Dotarem®-Enhanced MRI Compared to Gadovist®/Gadavist®-Enhanced MRI in the Diagnosis of Brain Tumors Completed
  2. Phase 4 Perampanel in Seizure Patients With Primary Glial Brain Tumors Completed
  3. Phase 4 Stereotactic Body Radiotherapy for Head and Neck Tumors Completed
  4. Phase 4 1 Week Versus 6 Weeks of Levetiracetam in Surgical Brain Tumor Patients Completed
  5. Phase 4 Bioequivalence Study of Temozolomide in Patients With Primary Tumors of the Central Nervous System Completed
  6. Phase 3 Combination Chemotherapy Followed By Peripheral Stem Cell Transplant in Treating Young Patients With Newly Diagnosed Supratentorial Primitive Neuroectodermal Tumors or High-Risk Medulloblastoma Completed
  7. Phase 3 Vorinostat, Temozolomide, or Bevacizumab in Combination With Radiation Therapy Followed by Bevacizumab and Temozolomide in Young Patients With Newly Diagnosed High-Grade Glioma Completed
  8. Phase 3 Performance of Elucirem in DSC-MRI Perfusion of Brain Gliomas Completed
  9. Phase 3 Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain Completed
  10. Phase 3 Treatment of Patients With Newly Diagnosed Medulloblastoma, Supratentorial Primitive Neuroectodermal Tumor, or Atypical Teratoid Rhabdoid Tumor Completed
  11. Phase 3 Radiation Therapy (RT) and Temozolomide (TMZ) in Treating Patients With Newly Diagnosed Glioblastoma or Gliosarcoma Completed
  12. Phase 3 Comparing Two Forms of Head Immobilization for Stereotactic Radiotherapy Completed
  13. Phase 2 Adavosertib and Irinotecan Hydrochloride in Treating Younger Patients With Relapsed or Refractory Solid Tumors Completed
  14. Phase 2 Plerixafor After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed High Grade Glioma Completed
  15. Phase 2 A Phase I/II Trial of BMS-247550 for Treatment of Patients With Recurrent High-Grade Gliomas Completed
  16. Phase 2 Presurgery Bortezomib for Recurrent Malignant Gliomas Followed by Postop Bortezomib & Temozolomide Completed
  17. Phase 2 Palbociclib in Treating Patients With Relapsed or Refractory Rb Positive Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With Activating Alterations in Cell Cycle Genes (A Pediatric MATCH Treatment Trial) Completed
  18. Phase 2 Safety and Efficacy of PF-299804 (Dacomitinib), a Pan-HER Irreversible Inhibitor, in Patients With Recurrent Glioblastoma With EGFR Amplification or Presence of EGFRvIII Mutation. A Phase II CT. Completed
  19. Phase 2 Pegylated Interferon ALFA-2b in Children With Juvenile Pilocytic Astrocytomas and Optic Pathway Gliomas Completed
  20. Phase 2 Dovitinib in Treating Patients With Recurrent or Progressive Glioblastoma Completed
  21. Phase 2 Oral Pazopanib Plus Oral Topotecan Metronomic Antiangiogenic Therapy for Recurrent Glioblastoma Multiforme (A) Without Prior Bevacizumab Exposure and (B) After Failing Prior Bevacizumab Completed
  22. Phase 2 Bevacizumab and Irinotecan or Temozolomide in Treating Patients With Recurrent or Refractory Glioblastoma Multiforme or Gliosarcoma Completed
  23. Phase 2 Low Dose Naltrexone for Glioma Patients Completed
  24. Phase 2 Pazopanib in Treating Patients With Recurrent Glioblastoma Completed
  25. Phase 2 LBH589 and Bevacizumab in Patients With Recurrent High Grade Glioma Completed
  26. Phase 2 Temozolomide and Irinotecan Hydrochloride With or Without Bevacizumab in Treating Young Patients With Recurrent or Refractory Medulloblastoma or CNS Primitive Neuroectodermal Tumors Completed
  27. Phase 2 Autologous CMV-Specific Cytotoxic T Cells and Temozolomide in Treating Patients With Glioblastoma Completed
  28. Phase 2 Gossypol in Treating Patients With Progressive or Recurrent Glioblastoma Multiforme Completed
  29. Phase 2 Imatinib Mesylate in Treating Patients With Recurrent Brain Tumor Completed
  30. Phase 2 Convection-Enhanced Delivery (CED) of MDNA55 in Adults With Recurrent or Progressive Glioblastoma Completed
  31. Phase 2 Bortezomib, Temozolomide, and Regional Radiation Therapy in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma Completed
  32. Phase 2 Antineoplaston Therapy in Treating Patients With Primary Malignant Brain Tumors Completed
  33. Phase 2 Sorafenib Tosylate and Temsirolimus in Treating Patients With Recurrent Glioblastoma Completed
  34. Phase 2 Bevacizumab and Erlotinib After Radiation Therapy and Temozolomide in Treating Patients With Newly Diagnosed Glioblastoma Multiforme or Gliosarcoma Completed
  35. Phase 2 Bevacizumab, Temozolomide and Hypofractionated Radiotherapy for Patients With Newly Diagnosed Malignant Glioma Completed
  36. Phase 2 Study of MEK162 for Children With Low-Grade Gliomas Completed
  37. Phase 2 Phase 1-2 of Temozolomide and Hypofractionated Radiotherapy in Tx of Supratentorial Glioblastoma Multiform Completed
  38. Phase 2 Tazemetostat in Treating Patients With Relapsed or Refractory Advanced Solid Tumors, Non-Hodgkin Lymphoma, or Histiocytic Disorders With EZH2, SMARCB1, or SMARCA4 Gene Mutations (A Pediatric MATCH Treatment Trial) Completed
  39. Phase 2 Tipifarnib and Radiation Therapy in Treating Young Patients With Brainstem Glioma Completed
  40. Phase 2 Clinical and Molecular-Metabolic Phase II Trial of Perifosine for Recurrent/Progressive Malignant Gliomas Completed
  41. Phase 2 PNOC 001: Phase II Study of Everolimus for Recurrent or Progressive Low-grade Gliomas in Children Completed
  42. Phase 2 Nivolumab for Recurrent or Progressive IDH Mutant Gliomas Completed
  43. Phase 2 Bevacizumab Beyond Progression (BBP) Completed
  44. Phase 2 Veliparib and Temozolomide in Treating Patients With Recurrent Glioblastoma Completed

Showing the 50 most-cited and recently-updated of 233 trials. Browse the full registry →

Trial data sourced from ClinicalTrials.gov. Counts describe the research landscape and are not a treatment recommendation. Informational only — not medical advice.

What the trials found Updated — new results For clinicians

Brain Cancer: what the trials found

Elucirem is a newly established intervention in the treatment of brain cancer 1. Other established interventions include temozolomide [7, 8], concurrent temozolomide 15, bevacizumab 13, and carboplatin 14.

Nivolumab has been evaluated across multiple trials. One study showed no significant difference in overall survival (OS) between groups (p=0.3402), while another trial demonstrated a statistically significant difference in OS (p=0.0037) with 21.2% of patients reaching the 24-month OS mark [9, 10].

Other established interventions include stereotactic body radiotherapy 4, perampanel, which showed zero instances of adverse events attributable to treatment in a small cohort 5, and filgrastim, where progression-free survival (PFS) varied significantly by risk group but not by ERBB2 status 16.

Supportive or adjunctive measures include injection tramadol 3, levetiracetam (which showed no significant change in neurotoxicity scores, p=0.7824) 2, cholecalciferol (no significant difference in hospital stay duration) 12, and a GTC frame 17. Dotarem® demonstrated high rates of good or excellent lesion visualization across multiple cohorts 6.

Recent results — preliminary, needs further review

  • MEK162 20
  • Cabozantinib S-malate 21

For the clinician treating this condition

  • Nivolumab shows inconsistent results across trials; while one study showed no significant difference in OS, another demonstrated a statistically significant improvement in 24-month survival rates.
  • Concurrent temozolomide was evaluated for median overall survival and progression-free survival, but did not show statistically significant differences between groups 15.
  • Perampanel was associated with zero reported adverse events in a small study cohort 5.

AI synthesis of 14 cited trials, updated Jul 26, 2026. Informational only — not medical advice; trial data sourced from ClinicalTrials.gov. How we use AI.

HCP Mode — summaries include clinical detail, trial data, and statistical outcomes.
Patient Mode — summaries use plain language, avoiding clinical jargon.
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