N/A
Completed N=22
Effects of a Combined Transcranial Magnetic Stimulation (TMS) and Cognitive Training in Alzheimer Patients
Source: ClinicalTrials.gov NCT01504958 ↗Enrolled (actual)
22
Serious AEs
4.6%
Results posted
Jun 2017
Primary outcomePrimary: Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-Cog) — 1.79; -0.20; -0.66 percentage change
Summary
This study looks at the potential benefits of combining cognitive training (mental exercises) together with transcranial magnetic stimulation (also known as TMS) to see if this can make a difference in the condition of people with Alzheimer's disease by improving their disease and the cognitive decline that goes along with it.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Alzheimer's Disease Assessment Scale - Cognitive Subscale (ADAS-Cog) |
1.79; -0.20; -0.66 | — |
| SECONDARY Clinical Global Impression of Change (CGIC) |
3.25; 4.40; 4.08 | — |
| SECONDARY Alzheimer's Disease Cooperative Study - Activities of Daily Living Inventory (ADCS-ADL) |
72.67; 73.60; 65.75; 69.78; 71.20; 61.75 | — |
Eligibility Criteria
Inclusion Criteria
- Male or female age 55-90
- Diagnosed with mild to moderate AD according to DSM-IV criteria
- Diagnosis of dementia of the Alzheimer's type according to the criteria established by the NINCDS-ADRDA
- Normal or corrected normal ability to see and hear
- Primary language is English
Exclusion Criteria
- IQ below 85
- Any major structural abnormalities on MRI (eg. Infarction, intracerebral malformation)
- Any symptoms of disease or abnormalities sufficient to cause memory impairment other than AD (eg. Normal pressure hydrocephalus, progressive supranuclear palsy)
- Any functional psychiatric disorder (eg. Schizophrenia)
- Chronic uncontrolled medical conditions that may cause a medical emergency in case of a provoked seizure (eg. Cardiac malformation)
- History of seizures, diagnosis of epilepsy
- Metal implants excluding dental fillings or any of the following medical devices: pacemaker, implanted medication pump, vagal nerve stimulator, deep brain stimulator, TENS unit (unless removed completely for this study), cerebral spinal fluid shunt
- Recent withdrawal from the following drugs: alcohol, barbiturates, benzodiazepines, meprobamate, chloral hydrate
Data sourced from ClinicalTrials.gov (NCT01504958). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.