N/A
N=200
The Impact of SCN9A Gene Polymorphism on Individual Pain Perception in the General Population
Pain · Surgery
Bottom Line
View on ClinicalTrials.gov: NCT01507493 ↗Enrolled (actual)
200
Serious AEs
0.0%
Results posted
Sep 2014
Primary outcome: Primary: Opioid Consumption Dose 48h After Operation. — 37.4; 50.4 microgramme
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- —
- Age
- Adult, Older Adult · 20+ yrs
- Sex
- All
- Sponsor
- Xianwei Zhang
- Primary completion
- Dec 2012
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Opioid Consumption Dose 48h After Operation. |
37.4; 50.4 | — |
| PRIMARY PCA Press Frequency 48h After Operation. |
8.8; 19.9 | — |
| SECONDARY The Visual Analog Scale 48h After Operation. |
6.9; 5.0 | — |
| SECONDARY Preoperative Pressure Pain Threshold (PPT) |
3.6; 3.7 | — |
| SECONDARY Preoperative Pressure Pain Tolerance (PTO) |
6.6; 6.5 | — |
Summary
This study was conducted to explore whether the non-synonymous single-nucleotide polymorphisms in SCN9A gene can predict individual basal pain perception and postoperative pain intensity in the general population undergoing upper abdominal surgery. Methods: Patients receiving elective upper abdominal surgery under general anesthesia were recruited into this study. Genotyping of SCN9A was carried out by direct sequencing. The investigators measured their preoperative pressure pain threshold (PPT) and pressure pain tolerance (PTO). The visual analog scale (VAS) was used for pain evaluation at rest during patient-controlled analgesia (PCA) treatment 0 h, 12 h ,24 h and 48h after operation. And the PCA press frequency and drug consumption were recorded.
Eligibility Criteria
Inclusion Criteria
- Aged 20-70 years
- Receiving elective upper abdominal surgery
- Anesthesiologists (ASA) physical status I or II
- Received PCA administration
- Agreed to participate the research
Exclusion Criteria
- History of chronic pain
- Psychiatric diseases
- Diabetes mellitus
- Severe cardiovascular diseases
- Kidney or liver diseases
- Alcohol or drug abuse
- Heavy smoker
- Pregnancy or at lactation period
- Refused PCA administration
- Disagree to participate to the research
Data sourced from ClinicalTrials.gov (NCT01507493). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.