N/A N=33 Randomized Treatment

Effect of Laser Use on Guided Tissue Regeneration in Treatment of Molar Teeth With Class 2 Furcation Affected by Periodontitis

Furcation Defects · Periodontitis · Alveolar Bone Loss Beyond Furcation

Bottom Line

View on ClinicalTrials.gov: NCT01522131 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Jun 2014

Primary outcome: Primary: Change in Clinical Attachment( Gain or Loss) Measured by Horizontal Clinical Attachment Loss(in mm) From Baseline to 6 Months. — -.82; -1.26 mm

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: bioresorbable membrane alonewill be used for regeneration of the periodontium(control) (Procedure)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: The University of Texas Health Science Center, Houston
Primary completion: Jun 2013

Outcome Measures

Outcome	Result	p-value
PRIMARY Change in Clinical Attachment( Gain or Loss) Measured by Horizontal Clinical Attachment Loss(in mm) From Baseline to 6 Months.	-.82; -1.26	—
SECONDARY Clinical Evidence of Regeneration of Class 2 Furcation Defects Based on Changes in Vertical Pocket Depth Measurement(in mm)	-.79; -.88	—

Summary

Purpose: The proposed study will evaluate and compare the clinical response of using bioresorbable collagen membrane alone or defect debridement with erbium Laser irradiation in conjunction with bioresorbable collagen membrane in the treatment of Class II furcation defects in maxillary and mandibular teeth. The study will examine whether there is a superior regeneration potential when the laser energy is combined with membrane defect isolation. Procedure: The study will use 2 groups, a control group and a test group with 16 patients in each group, with severe chronic periodontitis having clinical or radiographic evidence of Class II furcation defects in the buccal or lingual of the mandibular molars or Class II furcation defects on the buccal of maxillary molars. 16 patients will serve as the control group and open flap debridement with bioresorbable collagen membrane will be the mode of treatment. Group 2: 16 patients will serve as the test group and will undergo open flap debridement in conjunction with Er, Cr: YSGG laser irradiation and a bioresorbable collagen membrane will be used.

Eligibility Criteria

Inclusion Criteria

should be 18 years of age in good general health
should exhibit an O'Leary plaque score of 20% or less after initial therapy
class II furcations defects should be present in the buccal of the maxillary molars or buccal or lingual of the mandibular molars
tooth mobility should not exceed Miller Class II

Exclusion Criteria

patients who will be excluded include those with known hypersensitivity or allergy to chlorhexidine,
uncontrolled diabetics,
patients who are immunocompromised,
who have taken steroids within 6 months of study enrollment,
individuals who are pregnant and heavy smokers (> 10 cigarettes/day)

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01522131). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.