N/A
Completed N=22
Investigation of the Effects of Bariatric Surgery on Taste Reward in Humans
Source: ClinicalTrials.gov NCT01531738 ↗Enrolled (actual)
22
Serious AEs
0.0%
Results posted
Oct 2020
Primary outcomePrimary: Breakpoints as Assessed by Change in the Number of Mouse Clicks in the Last Completed Ratio — 0; 320 Clicks
Summary
The investigators hypothesize that some of these changes in the reduced appetite after surgery may be due to alterations in taste. The aim is to compare obese patients before and after bariatric surgery (gastric bypass and banding) to define the reward value of sweet, fatty and vegetable/fruit taste in obese individuals, and how this changes after surgery.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Breakpoints as Assessed by Change in the Number of Mouse Clicks in the Last Completed Ratio |
0; 320 | — |
| SECONDARY Hunger |
20; -60 | — |
| SECONDARY Body Mass Index |
-0.2; -6.2 | — |
Eligibility Criteria
Inclusion Criteria
- BMI of 18-25 for normal weight volunteers
- BMI of >30 for obese patients
Exclusion Criteria
- Pregnancy
- breast feeding
- substance abuse
- consumption of more than 3 alcoholic units per day
- severe psychiatric illness
- lack of understanding of test instructions
- diabetes mellitus
- chronic medical conditions making a general anaesthetic unsafe
- allergy to stimulus ingredients
- active smoking
Data sourced from ClinicalTrials.gov (NCT01531738). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.