N/A N=22

Investigation of the Effects of Bariatric Surgery on Taste Reward in Humans

Obesity

Bottom Line

View on ClinicalTrials.gov: NCT01531738 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Oct 2020

Primary outcome: Primary: Breakpoints as Assessed by Change in the Number of Mouse Clicks in the Last Completed Ratio — 0; 320 Clicks

Study Design & Population

Study type: Observational
Phase: N/A
Interventions: —
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Imperial College London
Primary completion: Jan 2012

Outcome Measures

Outcome	Result	p-value
PRIMARY Breakpoints as Assessed by Change in the Number of Mouse Clicks in the Last Completed Ratio	0; 320	—
SECONDARY Hunger	20; -60	—
SECONDARY Body Mass Index	-0.2; -6.2	—

Summary

The investigators hypothesize that some of these changes in the reduced appetite after surgery may be due to alterations in taste. The aim is to compare obese patients before and after bariatric surgery (gastric bypass and banding) to define the reward value of sweet, fatty and vegetable/fruit taste in obese individuals, and how this changes after surgery.

Eligibility Criteria

Inclusion Criteria

BMI of 18-25 for normal weight volunteers
BMI of >30 for obese patients

Exclusion Criteria

Pregnancy
breast feeding
substance abuse
consumption of more than 3 alcoholic units per day
severe psychiatric illness
lack of understanding of test instructions
diabetes mellitus
chronic medical conditions making a general anaesthetic unsafe
allergy to stimulus ingredients
active smoking

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01531738). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.