Phase 4
N=200
Effect of Low-Dose Dexamethasone on the Incidence of Hyperglycemia Following Surgery
Postoperative Complications
Bottom Line
View on ClinicalTrials.gov: NCT01545700 ↗Enrolled (actual)
200
Serious AEs
0.0%
Results posted
Jan 2013
Primary outcome: Primary: Serum Blood Glucose Concentrations — 101; 137; 140; 141 mg/dl
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- Control-saline (Drug); Dexamethasone 4 mg (Drug); Dexamethasone 8 mg (Drug); Control saline (Drug)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- Female
- Sponsor
- Endeavor Health
- Primary completion
- Nov 2012
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Serum Blood Glucose Concentrations |
101; 137; 140; 141; 139; 107 | — |
| SECONDARY Pain Scores |
50; 47; 45; 50; 45; 44.5 | — |
Summary
The question of a possible hyperglycemic effect from single-dose dexamethasone is an important issue for clinicians managing patients in the intraoperative and postoperative periods. Recent evidence suggests that even moderate elevations in blood glucose levels may be associated with adverse events.
The aim of this clinical investigation is to determine whether standard clinical doses of dexamethasone produce hyperglycemia in the perioperative period.
Eligibility Criteria
Inclusion Criteria
- Patients presenting for elective gynecologic surgery
Exclusion Criteria
- Age 90, patients receiving chronic or preoperative steroids,or allergy to dexamethasone.
Data sourced from ClinicalTrials.gov (NCT01545700). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.