Phase 4 Completed N=200 Randomized Quadruple-blind Treatment

Effect of Low-Dose Dexamethasone on the Incidence of Hyperglycemia Following Surgery

Postoperative Complications

Source: ClinicalTrials.gov NCT01545700 ↗

Enrolled (actual)

200

Serious AEs

0.0%

Results posted

Jan 2013

Primary outcomePrimary: Serum Blood Glucose Concentrations — 101; 137; 140; 141 mg/dl

Summary

The question of a possible hyperglycemic effect from single-dose dexamethasone is an important issue for clinicians managing patients in the intraoperative and postoperative periods. Recent evidence suggests that even moderate elevations in blood glucose levels may be associated with adverse events. The aim of this clinical investigation is to determine whether standard clinical doses of dexamethasone produce hyperglycemia in the perioperative period.

Outcome Measures

Outcome	Result	p-value
PRIMARY Serum Blood Glucose Concentrations	101; 137; 140; 141; 139; 107	—
SECONDARY Pain Scores	50; 47; 45; 50; 45; 44.5	—

Eligibility Criteria

Inclusion Criteria

Patients presenting for elective gynecologic surgery

Exclusion Criteria

Age 90, patients receiving chronic or preoperative steroids,or allergy to dexamethasone.

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01545700). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.