Phase 4
Completed N=250
Study of the Effectiveness of Administration of Meperidine on the Length of Active Phase of Labor in Women
Source: ClinicalTrials.gov NCT01555671 ↗Enrolled (actual)
250
Serious AEs
0.0%
Results posted
Sep 2021
Primary outcomePrimary: The Duration of Active Phase of Labour — 249; 304 minutes — p=0.029
◆ Published Evidence
Established
43citations · ~3 / year
A comparison between remifentanil and meperidine for labor analgesia: a systematic review.
Summary
This study aims to evaluate the effect of meperidine on the length of active phase of labor in nulliparous or multiparous women, who will be randomized into two (control and study) groups. Our hypothesis is that the use of meperidine during active labor has no effect on the duration of labor.
Linked Publications (4)
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A comparison between remifentanil and meperidine for labor analgesia: a systematic review.
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Effect of pethidine administered during the first stage of labor on the acid-base status at birth.
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Meperidine for dystocia during the first stage of labor: A randomized controlled trial.
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Effect of meperidine on uterine contractility during pregnancy and prelabor.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY The Duration of Active Phase of Labour |
249; 304 | 0.029 sig |
| SECONDARY Total Duration of Labour |
273; 331 | — |
| SECONDARY Duration of the Second Stage of Labour |
24; 27 | — |
Eligibility Criteria
Inclusion Criteria
- gestational age between 38 and 42 weeks
- live fetus
- cephalic presentation
- in active phase of labour
Exclusion Criteria
- placenta previa, placental abruption
- caesarean section or any uterine scarring
- multiple gestation
- fetal macrosomia (≥4000 g)
- meperidine allergy
- use any kind of labour induction or augmentation before on admission for delivery in our hospital
Data sourced from ClinicalTrials.gov (NCT01555671) and the linked publication. Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.