Phase 2 Completed N=205 Randomized Single-blind Prevention

Remote Ischemic Preconditioning Prior to Vascular Surgery

Peripheral arterial disease · Vascular Surgery

Source: ClinicalTrials.gov NCT01558596 ↗

Enrolled (actual)

205

Serious AEs

6.5%

Results posted

Dec 2016

Primary outcomePrimary: Troponin I Elevation Above the Upper Reference Limit (URL) — 25; 22 participants

Summary

The investigators have previously shown that elective vascular surgery is a high-risk operation with an anticipated risk of either death or heart attack of 15%. This study is testing whether a protocol of remote ischemic preconditioning (RIPC) applied 24 hours prior to the operation is safe, feasible and reduces the incidence of an adverse, perioperative cardiac complication.

Outcome Measures

Outcome	Result	p-value
PRIMARY Troponin I Elevation Above the Upper Reference Limit (URL)	25; 22	—

Eligibility Criteria

Inclusion Criteria

Undergoing elective major vascular surgery at the Minneapolis VA Medical Center for abdominal aortic aneurysm, carotid disease or limb ischemia.
Age > 18.
Provides informed consent.

Exclusion Criteria

Hypertensive crisis
Peripheral arterial disease of the upper extremities
Arteriovenous (AV) fistula
Acute Coronary Syndrome (ACS) in the last 6 months
Severe valvular heart disease
Pregnant women
Unable to provide consent

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01558596). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.