Phase 4
N=60
Testing the Anesthetic Effectiveness of Three Different Dental Local Anesthetics Injected Next to a Lower First Molar
Anesthetic Effectiveness
Bottom Line
View on ClinicalTrials.gov: NCT01567839 ↗Enrolled (actual)
60
Serious AEs
0.0%
Results posted
Jan 2014
Primary outcome: Primary: Successful Pulpal Anesthesia. — 37; 27; 22; 33 participants
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 4
- Interventions
- Mandibular buccal Infiltration injection (Procedure)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Ohio State University
- Primary completion
- Mar 2013
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Successful Pulpal Anesthesia. |
37; 27; 22; 33; 20; 19 | — |
Summary
Infiltration (injecting next to the tooth) injections are common in dentistry and a number of studies have shown that articaine anesthetic, when injected next to the tooth as a supplemental injection, works very well following a typical inferior alveolar (lower jaw) nerve block. No study has compared 4% articaine with 1:100,000 epinephrine, 4% prilocaine with 1:200,000 epinephrine, and 4% lidocaine with 1:100,000 epinephrine in mandibular (lower jaw) infiltration injections of the first molar. The purpose of this prospective, randomized, double-blind, crossover study is to compare the degree of anesthesia obtained from the three solutions as a primary infiltration injection next to the mandibular first molar. The investigators also will record the pain of injection and postoperative pain.
Eligibility Criteria
Inclusion Criteria
- between the ages of 18 and 65 years.
- in good health (ASA classification II or lower).
- able to provide informed consent.
Exclusion Criteria
- allergy to articaine, lidocaine or prilocaine.
- history of significant medical problems (ASA classification III or greater).
- depression (taking tri-cyclic antidepressant medications to control).
- have taken CNS depressants (including alcohol or any analgesic medications) within the last 48 hours prior to testing.
- lactating or pregnant.
- inability to give informed consent.
Data sourced from ClinicalTrials.gov (NCT01567839). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.