Phase 4 N=31 Anesthetic Effect Duration Assessment
Healthy Volunteers
Primary: Duration of Anesthesia(Minutes) — 80; 140; 0; 400 Minutes
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Completed trials with posted results — search by concept, filter by the parameters that matter at the bedside.
Phase 4 N=60 Testing the Anesthetic Effectiveness of Three Different Dental Local Anesthetics Injected Next to a Lower First Molar
Anesthetic Effectiveness
Primary: Successful Pulpal Anesthesia. — 37; 27; 22; 33 participants
Phase 4 N=64 Comparison of Two Topical Anesthetics: Benzocaine Versus Pliaglis
Anesthesia of Mucous Membrane
Primary: Measurement of Pain Associated With Injection, in Millimeters, According to Visual Analog Scale — 38.5; 26.9 mm
Phase 3 N=59 The Effect of Local Anesthesia on Control of Intraoperative Physiologic Parameters and Post Operative Comfort
Pain, Procedural
Primary: Post Operative Pain — 13; 10 Participants
Phase 4 N=35 Effect of Post-Operative Anesthetics on Post-Operative Pain in Patients Receiving Endodontic Treatment
Endodontic Disease · Post Operative Pain · Symptomatic Irreversible Pulpitis
Primary: Post-operative Pain Level 6 Hours on a Visual Analog Scale — 64.2; 43.1 units on a scale
N/A N=49 Efficacy of Injected Local Anesthetic vs Topical Anesthetic in Cosmetic Injectable Fillers.
Anesthesia
Primary: Participants Anesthetic Preference — 32; 16 participant preference selection
Phase 4 N=80 Testing the Anesthetic Effectiveness of Buffered Articaine Injected Next to a Lower First Molar.
Anesthetic Effectiveness
Primary: Number of Participants Achieving Pulpal Anesthesia. — 52; 57 Participants
Phase 2 N=45 Safety and Effectiveness of Kovacaine Nasal Spray for Dental Anesthesia
Dental Anesthesia Efficacy
Primary: Pulpal Anesthesia — 25; 14 participants
Phase 4 N=201 Efficacy Study of Articaine Versus Lidocaine as Supplemental Infiltration in Inflamed Molars
Irreversible Pulpitis
Primary: Anesthetic Success Rate of Supplemental Infiltration Injection — 22; 25; 23; 12 Participants — p=.901
Phase 4 N=50 Lower Third Molar Removal With 2% and 4% Articaine
Impacted Third Molar Tooth · Adverse Reaction to Other Local Anesthetics
Primary: Onset of Anesthetic — 1.5; 1.5 minutes — p=0.192
Phase 4 N=100 The Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Lower Jaw Dental Injections
Pain
Primary: Number of Participants Achieving Pulpal Anesthesia Success. — 44; 40 Participants — p=1.00
N/A N=96 Comparing Two Anesthetic Techniques for Implant Placement
Edentulous Jaw · Dental Implant · Anesthesia, Local
Primary: Pain Perception by Numerical Rating Scale — 0; 0 score on a scale
Phase 4 N=150 Split Face Study of the Duration of Local Anesthetics
Anesthetics, Local
Primary: Time to Return to Baseline Sensation, as Determined by Binary Outcomes (Yes/no) in 15 Minute Increments — 54.34; 49.86; 43.13; 55.78 Minutes — p=0.93
Phase 4 N=20 Physiological Effects of Nitrous Oxide on Anaesthesia
Anesthesia
Primary: Pa t/Pa0 Sevo (Arterial Partial Pressure of Sevoflurane), t=Time(Minutes) — 0.32; 0.44; 0.23; 0.32 ratio
N/A N=42 The Effect of Microneedle Pretreatment on Topical Anesthesia
Pain
Primary: Visual Analog Scale Pain — 7; 12 Units on a Scale
Phase 4 N=23 Anesthesia and Postoperative Pain
Postoperative Pain
Primary: Score on a Pain Rating Scale (Numerical Analog Score) — 1.5; 4.9 scores on a scale
N/A N=30 Effect of Local Anaesthetic Volume on Axillary Brachial Plexus Block Duration
Brachial Plexus Blockade
Primary: Overall Duration of Sensory Block. — 165; 188 minutes — p=<0.001
Early Phase 1 N=70 Comparison of Chloroprocaine vs Lidocaine for Epidural Anesthesia in Cesarean Delivery
Surgical Anesthesia, Cesarean Section
Primary: The Onset Time to Surgical Anesthesia — 558; 655 seconds — p=0.10
Early Phase 1 N=60 The Effect of Er,Cr:YSGG Laser-assisted Topical Anesthetic on Oral Mucosal Anesthesia
Anesthesia
Primary: Insertion Depth at Initial Sensory Detection — 7.75; 4.65; 0.4; 8.55 mm
N/A N=50 Effectiveness of the Comfort-In Needle Free Injection System During Palatal Infiltrative Anesthesia
Physiological Effects of Drugs · Anesthetics
Primary: Pain Perception Measured by the Wong-Baker FACES Pain Rating Scale — 1.04; 4.24 score on a scale
Phase 4 N=40 Buffered vs. Unbuffered Local Anesthesia in Mandibular Molars Diagnosed With Symptomatic Irreversible Pulpitis
Symptomatic Irreversible Pulpitis
Primary: VAS Scores as Measures of Profoundness of Pulpal Anesthesia — 3.1; 1.2 Score on a scale
N/A N=154 Effect of Local Anesthetic Dose on Interscalene Block
Shoulder Arthroscopy · Interscalene Block
Primary: Handgrip Strength — 6.45; 2.98 kg
Phase 4 N=26 Clinical Trial Comparing Effectiveness of Buffered Versus Unbuffered Local Anesthetic in Children Ages 10-12 Years
Anesthesia, Local · Pain
Primary: Mean Pain Scores Following Injection — 3.0; 3.3 score on a scale — p=0.38
Phase 3 N=110 Comparison of Intranasal Kovacaine Mist, Tetracaine Alone, and Placebo for Anesthetizing Maxillary Teeth in Adults
Anesthesia
Primary: Number of Participants Who Completed the Study Dental Procedure After Without Need for Rescue by Injection of Local Anesthetic. — 84.1; 27.3; 27.3 percentage of patients
Phase 4 N=98 An Evaluation of the Effectiveness of Local Anesthetics Used During Intravenous Catheter Insertion
IV Insertion Pain
Primary: Differences in Patients' Perceptions of Pain Between Treatment Methods — 0.015; 0; 0; 1.909 units on a scale
Phase 4 N=90 The Effects of Scalp Block With Bupivacaine Versus Levobupivacaine
Hypertension
Primary: Change in Mean Arterial Pressure — 110; 105; 100 mmHg
Phase 3 N=44 Comparative Study of Two Topical Anesthetics Prior to Fractional Nonablative Laser Treatment of the Face
Anesthesia, Local · Photodamaged Skin · Topical and Infiltration Anesthetic Toxicity
Primary: Self-reported Pain After Laser Treatment — 4.5; 5.0 score on a scale — p=0.102
Phase 4 N=10 Influence of Anesthetic Technique on Acute and Chronic Neuropathic Pain
Acute Pain · Chronic Pain · Hernia
Primary: Pain Score, Chronic — 1.7; 1.5; 0; .8 score on a scale
Phase 4 N=25 Effectiveness Study of Different Local Anesthetic Mixtures
Pain
Primary: Length of Action — 6.63; 7.02; 7.48; 7.16 minutes — p=0.359
N/A N=60 Propofol EC50 for Inducing Loss of Consciousness in General Combined Epidural Anesthesia
Gastric Cancer
Primary: Propofol EC50 for Inducing Loss of Conciousness — 2.97; 3.36 ug/ml