Early Phase 1
Completed N=33
Tango for Treatment of Motor and Non-motor Manifestations in Parkinson's Disease.
Parkinson's Disease
Source: ClinicalTrials.gov NCT01573260 ↗
Enrolled (actual)
33
Serious AEs
0.0%
Results posted
Feb 2016
Primary outcomePrimary: Severity of PD (Unified Parkinson Disease Rating Scale - UPDRS, 2008 Version) — 24.7; 30.5; 24.4; 30.2 units on a scale
Summary
Parkinson's disease involves many motor difficulties as well as non-motor ones. Recent research has strongly suggested that exercise is very important for Parkinson's disease. We are interested especially in dance as a form of exercise, because it combines physical movements with balance tasks, social engagement, and mental stimulation. Therefore, we think dance classes may be a very beneficial exercise for Parkinson's disease; the purpose of this study is to see if Argentinean Tango classes might improve motor and non-motor manifestations of Parkinson's disease.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Severity of PD (Unified Parkinson Disease Rating Scale - UPDRS, 2008 Version) |
24.7; 30.5; 24.4; 30.2 | — |
| SECONDARY MiniBESTest |
28.3; 27.1; 28.8; 26.0 | — |
| SECONDARY Number of Participants With a Fall in the Past 3 Months Using the Falls Questionnaire From the Canadian Longitudinal Study of Aging |
0; 1 | — |
| SECONDARY Freezing of Gait Questionnare (FOG_Q) |
2.0; 4.6; 2.7; 4.1 | — |
| SECONDARY The Purdue Pegboard |
14.4; 13.1; 13.8; 12.5 | — |
| SECONDARY The Montreal Cognitive Assessment |
27.0; 26.7; 27.4; 26.1 | — |
| SECONDARY The Beck Depression Inventory (BDI) |
7.9; 7.7; 7.7; 7.3 | — |
| SECONDARY Apathy Evaluation Scale (AES) |
28.9; 26.8; 31.3; 29.4 | — |
| SECONDARY The Krupp Fatigue Severity Scale |
34.3; 33.3; 30.8; 35.9 | — |
| SECONDARY The Parkinson's Disease Questionnaire is a Quality of Life(PDQ-39) |
26.8; 25.8; 26.4; 24.5 | — |
| SECONDARY Adherence to Treatment |
6; 0 | — |
| SECONDARY Clinical Global Impression of Change |
3.4; 3 | — |
| SECONDARY Exit Questionnaire |
1.1; 2.1; 1.1; 2 | — |
| SECONDARY Adverse Events |
22; 13 | — |
Eligibility Criteria
Inclusion Criteria
- Patients will be eligible for inclusion if they have a diagnosis of idiopathic PD.
- The subjects must speak either English or French sufficiently to fill out questionnaires and understand the instructions for dance classes (classes will be bilingual).
Exclusion Criteria
- Patients who cannot stand for at least 30 min and walk for ≥3 m without an assistive device.
- Individuals with Hoehn and Yahr stage IV- V (severe and nonambulatory)
- Dementia, defined according to PD dementia criteria as MMSE< 26/30 and ADL impairment secondary to cognitive loss, or inability to understand consent process60
- Serious hearing and vision problems that could affect the participation in dance classes.
- Change to dopaminergic therapy over the preceding three months, or changes to antiparkinsonian medication are anticipated during the study protocol
- Serious medical conditions, including cardiac disease or evidence of musculoskeletal problem which precludes dancing or can be worsened by exercise
- History of frequent falls, with more than 3 falls in the last 12 months
Data sourced from ClinicalTrials.gov (NCT01573260). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.