Phase 4
Completed N=100
The Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Lower Jaw Dental Injections
Source: ClinicalTrials.gov NCT01574807 ↗Enrolled (actual)
100
Serious AEs
0.0%
Results posted
Nov 2020
Primary outcomePrimary: Number of Participants Achieving Pulpal Anesthesia Success. — 44; 40 Participants — p=1.00
◆ Published Evidence
No publication linked
No peer-reviewed publication reporting this trial's results has been linked yet. This can indicate results are unpublished — a known publication-bias signal. We re-check periodically.
Summary
The inferior alveolar nerve block (shot) is the most frequently used injection technique for achieving local anesthesia (numbness) for the teeth in the lower jaw. However, this injection does not always result in successful pulpal (tooth) anesthesia (patient felt pain). No study has combined mepivacaine and lidocaine anesthetics (numbing solutions) for this type of injection (shot). The investigators propose to compare an injection of mepivacaine followed by lidocaine to an injection of lidocaine followed by lidocaine to determine if there is a difference in effectiveness.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants Achieving Pulpal Anesthesia Success. |
44; 40 | 1.00 |
Eligibility Criteria
Inclusion Criteria
- between the ages of 18 and 65 years
- good health (ASA classification I or II)
- able to provide informed consent
Exclusion Criteria
- allergy to lidocaine or mepivacaine
- history of significant medical problem (ASA classification III or greater)
- depression
- have taken CNS depressants (including alcohol or any analgesic medications) within the last 48 hours
- lactating or pregnant
- inability to give informed consent
Data sourced from ClinicalTrials.gov (NCT01574807). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.