Phase 4 N=100 Randomized Double-blind Treatment

The Anesthetic Efficacy of 3% Mepivacaine Plus 2% Lidocaine With 1:100,000 Epinephrine for Lower Jaw Dental Injections

Pain

Bottom Line

View on ClinicalTrials.gov: NCT01574807 ↗

Enrolled (actual)

100

Serious AEs

0.0%

Results posted

Nov 2020

Primary outcome: Primary: Number of Participants Achieving Pulpal Anesthesia Success. — 44; 40 Participants — p=1.00

Study Design & Population

Study type: Interventional
Phase: Phase 4
Interventions: mepivacaine + lidocaine followed by lidocaine +lidocaine (Drug); lidocaine + lidocaine followed by mepivacaine + lidocaine (Drug)
Age: Adult, Older Adult · 18+ yrs
Sex: All
Sponsor: Ohio State University
Primary completion: May 2013

Outcome Measures

Outcome	Result	p-value
PRIMARY Number of Participants Achieving Pulpal Anesthesia Success.	44; 40	1.00

Summary

The inferior alveolar nerve block (shot) is the most frequently used injection technique for achieving local anesthesia (numbness) for the teeth in the lower jaw. However, this injection does not always result in successful pulpal (tooth) anesthesia (patient felt pain). No study has combined mepivacaine and lidocaine anesthetics (numbing solutions) for this type of injection (shot). The investigators propose to compare an injection of mepivacaine followed by lidocaine to an injection of lidocaine followed by lidocaine to determine if there is a difference in effectiveness.

Eligibility Criteria

Inclusion Criteria

between the ages of 18 and 65 years
good health (ASA classification I or II)
able to provide informed consent

Exclusion Criteria

allergy to lidocaine or mepivacaine
history of significant medical problem (ASA classification III or greater)
depression
have taken CNS depressants (including alcohol or any analgesic medications) within the last 48 hours
lactating or pregnant
inability to give informed consent

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01574807). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.