N/A
N=38
The Neurobiology of Expectancy and Pain Perception
Pain
Bottom Line
View on ClinicalTrials.gov: NCT01575106 ↗Enrolled (actual)
38
Serious AEs
0.0%
Results posted
Oct 2017
Primary outcome: Primary: Subjective Response to Pain (0-20 Visual Analogue Scale) — 10.7; 11; 11.2; 8.1 units on a scale
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Heat pain applied using TSA or CHEPS (Device)
- Age
- Adult · 21+ yrs
- Sex
- All
- Sponsor
- Massachusetts General Hospital
- Primary completion
- Oct 2013
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Subjective Response to Pain (0-20 Visual Analogue Scale) |
10.7; 11; 11.2; 8.1; 12.2; 10.8 | — |
| PRIMARY fMRI Signal Changes in the Dorsal Anterior Cingulate Cortex |
0.2; 0.3 | — |
Summary
This study will use using fMRI (functional Magnetic Resonance Imaging) to elucidate how contextual learning/expectation relieves or aggravates pain experience in the same cohort of subjects and the same study session.
Eligibility Criteria
Inclusion Criteria
- a) Healthy male and female adults aged 21-50
- b) No contraindications to fMRI scanning
- c) Right handed
Exclusion Criteria
- a) Current or past history of major medical, neurological, or psychiatric illness
- b) Pregnancy or breast feeding, menopause, and irregular menstrual cycles (length of cycle must be within 26 to 32 days)
- c) Claustrophobia
- d) History of head trauma
- e) History of impaired elimination
- f) Instability of responses to experimental pain (see Study Procedures Section)
- g) Use of psychotropic drugs, hormone treatments (including hormonal birth control) within 1 year
- h) Non-fluent speaker of English
Data sourced from ClinicalTrials.gov (NCT01575106). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.