N/A
N=117
Genetic Variation in Platelet Aggregation
Myocardial Infarction
Bottom Line
View on ClinicalTrials.gov: NCT01576536 ↗Enrolled (actual)
117
Serious AEs
0.9%
Results posted
Jun 2019
Primary outcome: Primary: LogEC50 Platelet Aggregation — 2.65; 2.62 nM
Study Design & Population
- Study type
- Observational
- Phase
- N/A
- Interventions
- —
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Vanderbilt University
- Primary completion
- Dec 2015
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY LogEC50 Platelet Aggregation |
2.65; 2.62 | — |
| SECONDARY Percentage, Adenosine Diphosphate (ADP) Induced Platelet Aggregation |
72.8; 75.8 | — |
| SECONDARY Percentage, Collagen Induced Platelet Aggregation |
84.3; 83.5 | — |
Summary
The aim of the study is to test whether genetic variation in the alpha 2A adrenergic receptor affects diurnal variation in platelet aggregation.
Eligibility Criteria
Inclusion Criteria
- Men and women aged 18 - 45 years inclusive.
- Women of the above age will be studied between day 1 and day 14 of a normal menstrual cycle.
- Subjects must be willing to give informed consent for the study and able to adhere to the study diet and study procedures.
- Subjects and immediate extended family up till grandparents will be Caucasians or African Americans only.
- Subjects will be free of any clinically significant disease.
- Clinical laboratory test (CBC, blood chemistry) will be within acceptable limits.
Exclusion Criteria
- Subjects who have taken any antiplatelet, anticoagulant or procoagulant medicines within the last three weeks preceding the study.
- Subjects who have taken medications (including over the counter medications) other than oral contraceptives in the past two weeks.
- Subjects who smoke or have smoked in the past 3 months.
- Subjects who are presently or were formerly a narcotic addict or alcoholic.
- Females with a positive pregnancy test.
- Females who are breast feeding.
Data sourced from ClinicalTrials.gov (NCT01576536). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.