N/A
Completed N=50
B-type Natriuretic Peptide as a Surrogate Marker Guiding Post-operative Fluid Off-loading
Fluid Over-load
Source: ClinicalTrials.gov NCT01584518 ↗
Enrolled (actual)
50
Serious AEs
8.0%
Results posted
Mar 2016
Primary outcomePrimary: Length of Stay — 4; 6 days
Summary
The long-range goal of this proposal is to decrease morbidity and mortality related to pulmonary edema and congestive heart failure (CHF) in post-operative patients. The short-range goal is to determine a mechanistic endpoint when therapy for impending heart failure can be initiated and terminated based on B-type natriuretic peptide (BNP) levels. The investigators propose to utilize changing levels of BNP as a surrogate marker for CHF.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Length of Stay |
4; 6 | — |
Eligibility Criteria
Inclusion Criteria
- General Surgery patients with history of coronary artery disease, congestive heart failure, pulmonary hypertension
- Cardiac surgery patients undergoing CABG (coronary artery bypass grafting) and valve replacements
Exclusion Criteria
- Recent myocardial infarction (within 3 months).
- ASA class 4 and more.
- Emergency surgeries.
Data sourced from ClinicalTrials.gov (NCT01584518). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.