N/A
N=150
Lidocaine and Prevention of Chronic Pain
Surgery
Bottom Line
View on ClinicalTrials.gov: NCT01619852 ↗Enrolled (actual)
150
Serious AEs
0.0%
Results posted
Nov 2019
Primary outcome: Primary: Number of Participants With Chronic Persistent Pain 3 Months After Surgery as Determined by Character Severity (Yes/no). — 2; 6 participants — p=.19
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- .9 normal saline placebo (Drug); Group L (lidocaine) (Drug)
- Age
- Adult · 18+ yrs
- Sex
- Female
- Sponsor
- Northwestern University
- Primary completion
- Jul 2014
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants With Chronic Persistent Pain 3 Months After Surgery as Determined by Character Severity (Yes/no). |
2; 6 | .19 |
| SECONDARY Quality of Recovery |
158; 169 | 0.64 |
| SECONDARY Post-surgical Persistent Pain Using Validated Questionnaires (S-LANNS Questionnaire, McGill Questionnaire, Brief Pain Inventory) to Assess Pain Qualities in Accordance With IMMPACT Recommendations. |
3; 3; 4; 3; 0; 0 | 0.68 |
| SECONDARY Opioid Consumption |
34; 39 | .19 |
| SECONDARY Postoperative Pain |
116; 119 | .29 |
Summary
The study seeks to investigate a safe and inexpensive strategy to reduce persistent post-surgical pain that can affect up to 60% of patients undergoing surgical procedures.
Hypotheses: Perioperative systemic lidocaine reduces the persistence of chronic pain in patients undergoing surgical procedures.
Eligibility Criteria
Inclusion Criteria
- Age 18-64,
- Females undergoing gynecological, urological or breast surgery
Exclusion Criteria
- pregnant,
- history of chronic use of opioids,
- allergy to local anesthetics,
- history of cardiac arrhythmias Drop out: patient or surgeon request
Data sourced from ClinicalTrials.gov (NCT01619852). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.