N/A N=60 Randomized Prevention

Cerebral Blood Perfusion Changes After General Anesthesia for Craniotomy

Brain Neoplasms · Surgery · Hyperemia

Bottom Line

View on ClinicalTrials.gov: NCT01642147 ↗

Enrolled (actual)

Serious AEs

0.0%

Results posted

Apr 2013

Primary outcome: Primary: Mean Blood Flow Velocity in Middle Cerebral Artery — 63.7; 61.8 cm/s — p=0.554

Study Design & Population

Study type: Interventional
Phase: N/A
Interventions: Transcranial Doppler (TCD) (Device); jugular venous bulb catheterization (Procedure); Tumor removal surgery under general anesthesia (Procedure); Radial artery catheterization (Procedure); Abdominal surgery under general anesthesia (Procedure)
Age: Adult · 25+ yrs
Sex: All
Sponsor: Huashan Hospital
Primary completion: Jan 2013

Outcome Measures

Outcome	Result	p-value
PRIMARY Mean Blood Flow Velocity in Middle Cerebral Artery	69.7; 59.2	<0.001 sig
PRIMARY Mean Blood Flow Velocity in Middle Cerebral Artery	69.7; 59.2	<0.001 sig
PRIMARY Mean Blood Flow Velocity in Middle Cerebral Artery	69.7; 59.2	<0.001 sig
PRIMARY Mean Blood Flow Velocity in Middle Cerebral Artery	69.7; 59.2	<0.001 sig
PRIMARY Mean Blood Flow Velocity in Middle Cerebral Artery	69.7; 59.2	<0.001 sig
PRIMARY Mean Blood Flow Velocity in Middle Cerebral Artery	69.7; 59.2	<0.001 sig
PRIMARY Oxygen Saturation of Jugular Venous Bulb	66.9	—
PRIMARY Oxygen Saturation of Jugular Venous Bulb	66.9	—
PRIMARY Oxygen Saturation of Jugular Venous Bulb	66.9	—
PRIMARY Oxygen Saturation of Jugular Venous Bulb	66.9	—
PRIMARY Oxygen Saturation of Jugular Venous Bulb	66.9	—
PRIMARY Oxygen Saturation of Jugular Venous Bulb	66.9	—

Summary

Few studies look into cerebral blood flow (CBF) changes during emergence from general anesthesia for craniotomy. The purpose of this study is to demonstrate CBF changes during emergence from general anesthesia for craniotomy, through monitoring blood oxygen saturation of jugular vein bulb and transcranial Doppler.

Eligibility Criteria

Inclusion Criteria

American Society of Anesthesia (ASA) physical status I or II
Scheduled for selective supratentorial tumor removal surgery or major abdominal surgery.

Exclusion Criteria

Patients with evidence of systemic hypertension, intracranial hypertension, cerebrovascular diseases, other coexisting medical conditions likely to affect cerebral autoregulation.
Preoperatively planned delayed tracheal extubation.
Pregnant or nursing women

View full record on ClinicalTrials.gov →

Data sourced from ClinicalTrials.gov (NCT01642147). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.