N/A
Completed N=60
Cerebral Blood Perfusion Changes After General Anesthesia for Craniotomy
Brain Cancer · Surgery · Hyperemia
Source: ClinicalTrials.gov NCT01642147 ↗
Enrolled (actual)
60
Serious AEs
0.0%
Results posted
Apr 2013
Primary outcomePrimary: Mean Blood Flow Velocity in Middle Cerebral Artery — 63.7; 61.8 cm/s — p=0.554
Summary
Few studies look into cerebral blood flow (CBF) changes during emergence from general anesthesia for craniotomy. The purpose of this study is to demonstrate CBF changes during emergence from general anesthesia for craniotomy, through monitoring blood oxygen saturation of jugular vein bulb and transcranial Doppler.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Mean Blood Flow Velocity in Middle Cerebral Artery |
69.7; 59.2 | <0.001 sig |
| PRIMARY Oxygen Saturation of Jugular Venous Bulb |
66.9 | — |
Eligibility Criteria
Inclusion Criteria
- American Society of Anesthesia (ASA) physical status I or II
- Scheduled for selective supratentorial tumor removal surgery or major abdominal surgery.
Exclusion Criteria
- Patients with evidence of systemic hypertension, intracranial hypertension, cerebrovascular diseases, other coexisting medical conditions likely to affect cerebral autoregulation.
- Preoperatively planned delayed tracheal extubation.
- Pregnant or nursing women
Data sourced from ClinicalTrials.gov (NCT01642147). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.