N/A
N=15
Role of the Supraspinal Opioidergic Circuit in Prefrontal TMS-Induced Analgesia
Pain
Bottom Line
View on ClinicalTrials.gov: NCT01643798 ↗Enrolled (actual)
15
Serious AEs
0.0%
Results posted
Apr 2014
Primary outcome: Primary: Pain Rating — 7.36; 5.61; 7.54; 6.75 units on a scale — p=<0.001
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Sham rTMS (Procedure); Real rTMS (Procedure)
- Age
- Adult · 18+ yrs
- Sex
- All
- Sponsor
- Medical University of South Carolina
- Primary completion
- May 2012
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Pain Rating |
7.36; 5.61; 7.54; 6.75 | <0.001 sig |
| PRIMARY Change in BOLD Signal in Pain Processing Regions During Pain, Including Supraspinal Opioidergic Structures |
0.15; 0.00; 0.10; 0.13 | .0003 sig |
Summary
Studies have shown that transcranial magnetic stimulation (TMS), a non-invasive form of brain stimulation, can reduce pain in the laboratory and in the clinic. The purpose of this study is to investigate how TMS relieves pain and affects pain circuitry in the brain. One of the primary study hypotheses is that opioid blockade will significantly reduce the pain relief produced by left prefrontal cortex TMS.
Eligibility Criteria
Inclusion Criteria
- healthy volunteers
- no history of depression or pain
- no metal in body
- no medications that lower seizure threshold
Exclusion Criteria
- history of depression or pain
- history of seizures or epilepsy
- metal implants in body
- medications that lower seizure threshold
- psychiatric medications
Data sourced from ClinicalTrials.gov (NCT01643798). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.