N/A
Completed N=60
ADHD Electrophysiological Subtypes and Implications in Transcranial Direct-current Stimulation
Source: ClinicalTrials.gov NCT01649232 ↗Enrolled (actual)
60
Serious AEs
0.0%
Results posted
Apr 2014
Primary outcomePrimary: Clinical Assessment (Amen Questionnaire) — 9.85; 3.55; 5.15; 3.54 units on a scale
Summary
In the present study the aim is to examine whether transcranial direct-current stimulation (tDCS) generated excitability changes and induce modifications of functional cortical architecture in Attention Deficit Hyperactivity Disorder (ADHD) patients. To achieve this, the investigators used an event-related potential (ERP) analysis based on 20 channel EEG recordings in ADHD subjects before and after bipolar tDCS-anode stimulation over F3/F4 or T5/T6 or P4/P3, during resting state and measure clinical scores and visual CPT tasks changes. Time courses and topography of independent component visual ERPs were compared before and after tDCS.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Clinical Assessment (Amen Questionnaire) |
9.85; 3.55; 5.15; 3.54 | — |
| SECONDARY Event-related Potentials Amplitude (ERPs) |
6.07; 5.40; 4.96; 4.77; 9.22; 7.01 | — |
| SECONDARY Event-related Potentials Latency (ERPs) |
323.78; 324.44; 321.56; 326.21; 348.67; 354.00 | — |
| SECONDARY Reaction Time (Behavior Task) |
466.95; 354.68; 444.65; 356.58; 467.04; 352.29 | — |
| SECONDARY Number of Omission and Commission Errors of Behavior Task |
11.22; 1.07; 12.22; 1.04; 0.83; 0.04 | — |
Eligibility Criteria
Inclusion criteria
- ADHD diagnosis.
- Age between 7 and 65 years.
- Comorbidities were no reason for subject exclusion.
Exclusion criteria
- Presence of psychosis.
- Subjects taking medication, they had refrained from taking methylphenidate during 24 hours before testing.
- Subjects taking other psychotropics were not included in the study.
- Subjects which had suffered of a head injury with subsequent loss of consciousness, and subjects suffering from neurological or systemic medical diseases were excluded from the study.
Data sourced from ClinicalTrials.gov (NCT01649232). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.