Phase 2
N=20
Optimization of Desflurane in Elderly Patients
Postoperative Cognitive Dysfunction
Bottom Line
View on ClinicalTrials.gov: NCT01700907 ↗Enrolled (actual)
20
Serious AEs
0.0%
Results posted
Nov 2014
Primary outcome: Primary: The Time From the End of Anesthesia to Extubation — 329.0; 636.0 second
Study Design & Population
- Study type
- Interventional
- Phase
- Phase 2
- Interventions
- Desflurane (Drug); Sevoflurane (Drug)
- Age
- Older Adult · 65+ yrs
- Sex
- All
- Sponsor
- Sapporo Medical University
- Primary completion
- Feb 2013
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY The Time From the End of Anesthesia to Extubation |
329.0; 636.0 | — |
| SECONDARY The Time From the End of Anesthesia to Eye Opening |
176.5; 315.0 | — |
| SECONDARY The Time From the End of Anesthesia to Following Commands |
246.5; 424.0 | — |
| SECONDARY Cognitive Function |
28.0; 28.0; 29.5; 29.0 | — |
| SECONDARY The Incidence of Postoperative Delirium |
2; 0 | — |
Summary
Various issues had been pointed out when undergoing the anesthesia for elderly patients with sevoflurane, such as delayed emergence, post-operative trouble with swallowing.
Desflurane, which has a lower blood/gas partition coefficient, is expected to contribute the better emergence, along with the recent progress on optimization of delivered amount of anesthesia.
The purpose of this study is to compare the time to emergence in long elderly patient cases with desflurane or sevoflurane, with the recently developed drug-delivery optimization system "Aisys®" (GE Healthcare Japan).
Eligibility Criteria
Inclusion Criteria
- Elderly patients (>= 65 yr-old), long operation (> 4hours), abdominal surgery patients
Exclusion Criteria
- Liver dysfunction, Renal dysfunction, preoperative dementia Neurosurgery patients, Cardiac surgery patients, obese patients(BMI>35)
Data sourced from ClinicalTrials.gov (NCT01700907). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.