Dexmedetomidine plus esketamine may reduce postoperative delirium and injury
Combined dexmedetomidine and esketamine may protect brain function after surgery
Perioperative combo of dexmedetomidine and esketamine lowers neuronal injury biomarkers and delirium risk in surgical patients.
A new analysis suggests a combination of two medications could lower the risk of confusion and protect brain health during and after surgery…
Gastrodin, intranasal insulin, and cognitive training show greatest preventive effectiveness for postoperative cognitive dysfunction after cardiac surgery
Insulin, Gastrodin, and Training May Protect Brain After Heart Surgery
A systematic review and Bayesian network meta-analysis of 46 RCTs (9,928 patients) ranked 20 strategies for preventing postoperative cogniti…
A review of 46 trials suggests certain drugs and cognitive training may help prevent confusion and memory loss after cardiac surgery.
Shenmai and Shenfu injections may reduce postoperative cognitive dysfunction incidence following surgical procedures
Two injections may help patients recover mental clarity after surgery
This meta-analysis of 16 RCTs involving 1,199 patients indicates that Shenmai and Shenfu injections are associated with higher MMSE scores a…
New data suggests that Shenmai and Shenfu injections could help patients regain mental clarity and awareness more quickly after undergoing s…
Review of ferroptosis role in postoperative cognitive dysfunction in older surgical patients
Aging and surgery may trigger brain cell death in older patients
This narrative review examines the potential role of ferroptosis in postoperative cognitive dysfunction among older surgical patients. The a…
A review suggests aging and surgery might trigger brain cell death in older patients, but scientists are not sure if this process causes the…
Bibliometric review of anesthesia-associated postoperative cognitive dysfunction in elderly patients from 2000 to 2024
Why Your Brain Fog After Surgery Might Start in Your Gut
This bibliometric review analyzed 923 publications indexed in the Web of Science Core Collection and PubMed database regarding anesthesia-as…
Understanding how surgery and anesthesia trigger brain inflammation could lead to new ways to prevent memory loss after operations.
Narrative review suggests spontaneous-breathing anesthesia may offer cognitive protection in elderly surgical patients
Breathing Naturally Might Protect Elderly Brains
A narrative review of existing clinical evidence suggests spontaneous-breathing anesthesia may have cognitive protective effects compared to…
Letting older patients breathe naturally during surgery could help keep their minds sharp by reducing brain stress and inflammation.
PENG block with bupivacaine reduces early POCD incidence after hip arthroplasty in older patients
PENG block may lower confusion and pain after hip surgery in older adults
In a randomized, double-blind study of 84 older patients undergoing hip arthroplasty, ultrasound-guided PENG block with 0.25% bupivacaine re…
An ultrasound-guided PENG block lowers confusion and pain after hip surgery in older adults, helping them move earlier and use fewer painkil…
Research across Cognitive Dysfunction
Related studies from across the Cognitive Dysfunction family.
Non-pharmacological interventions for sleep disturbances in mild cognitive impairment and early dementia provide management guidance
Sleep Care Plan for Early Dementia: Best Evidence
This integrative review and guideline identifies 44 evidence items across 11 themes for managing sleep disturbances in patients with mild co…
A new review maps 44 best evidence items for managing sleep problems in mild cognitive impairment and early dementia.
Higher adherence to MedDiet and DASH associated with better executive function in aging populations
Mediterranean and DASH diets linked to better brain health
This meta-analysis of 8 longitudinal cohorts involving 17,368 individuals in Europe and the United States found that higher adherence to the…
Specific dietary patterns like the Mediterranean and DASH diets may help protect memory and mental focus as people age.
Dysregulated tryptophan metabolism drives neurocognitive complications in approximately 40% of patients with chronic kidney disease
Tryptophan metabolism may link kidney disease to brain fog
This narrative review explores how dysregulated tryptophan metabolism, including kynurenine and indole pathways, contributes to cognitive im…
About 40% of people with chronic kidney disease experience cognitive issues, potentially linked to how the body processes a nutrient called …
Aerobic and combined physical-cognitive training programs may improve executive function and decision-making in older adults
Combined Physical and Cognitive Training May Improve Decision Making
This narrative review examines the impact of aerobic and combined physical-cognitive training on cognitive decline in healthy older adults. …
Combining aerobic exercise with cognitive training may improve executive functions and brain health in older adults to support better decisi…
Visual art therapy significantly improves global cognitive function and activities of daily living in older adults
Visual art therapy improves memory and daily tasks in seniors
This meta-analysis of randomized controlled trials indicates that visual art therapy improves global cognitive function (SMD = 0.39) and act…
Engaging in visual art therapy can help older adults improve their overall brain function and perform daily activities more easily.
Computerized cognitive training and cognitive stimulation therapy improve MMSE and MoCA scores in older adults
Computerized Training Shows Promise for Improving Cognitive Function
This Bayesian network meta-analysis of 35 randomized controlled trials evaluated multiple interventions for cognitive impairment in older ad…
New data from a large analysis suggests that computerized training and brain stimulation may help improve memory and thinking in older adult…
Prolonged FVEP-P2 latency is associated with Alzheimer's disease and other forms of dementia
Brain Signal Delays Linked to Alzheimer's and Dementia Types
This meta-analysis of 18 comparisons involving 1,778 participants found significantly prolonged FVEP-P2 latency in patients with Alzheimer's…
A large review found that specific brain signal delays are linked to Alzheimer's disease and other forms of cognitive decline.
Robot-based interventions reduce depressive and anxiety symptoms in older adults with cognitive impairment
Robot-based Interventions Reduce Depression in Older Adults with Cognitive Impairment
This meta-analysis of 514 older adults with cognitive impairment found that robot-based interventions significantly reduced depressive sympt…
New research suggests that robot-based interventions can help reduce feelings of depression and anxiety in older adults living with cognitiv…
Moderate-intensity resistance training improves cognitive performance and brain health markers in older adults
Resistance Training May Boost Brain Health in Older Adults
This narrative review of 28 peer-reviewed publications synthesizes evidence on the effects of low-, moderate-, and high-intensity resistance…
Lifting weights, especially at moderate intensity, may improve memory and thinking in older adults, a review finds.
Pain assessment guidelines for cognitively impaired older adults lack practical detail
Pain guidelines for dementia patients lack practical advice
This scoping review mapped pain assessment guidelines for hospitalized older adults with cognitive impairment. No Australian guidelines were…
A review finds most pain assessment guidelines for older adults with dementia offer little practical help for hospital staff.
Frailty associated with higher odds of cognitive impairment in patients with chronic kidney disease
Frailty increases risk of cognitive issues in kidney disease patients
This meta-analysis of 129,868 patients with chronic kidney disease (CKD) found that frailty is associated with a significantly higher risk o…
People with chronic kidney disease who experience frailty are much more likely to face memory and thinking problems than those who stay robu…
Natural compounds may alleviate anesthesia induced cognitive dysfunction through multi-target regulatory mechanisms
Natural Compounds May Help Protect Brains After Anesthesia
This systematic review evaluates 16 natural compounds, including flavonoids and polyphenols, regarding their role in mitigating anesthetic-i…
Certain natural compounds like flavonoids and polyphenols may help protect brain function from damage caused by inhalational anesthetics.
Questions about Postoperative cognitive dysfunction
Does using bupivacaine during hip replacement lower the risk of postoperative cognitive dysfunction?
Yes, a 2026 study found that a bupivacaine nerve block (PENG block) before hip replacement reduced POCD risk at 7 days (14.6% vs 37.2%).
Full answer →Is there a link between ferroptosis and postoperative cognitive dysfunction in older patients?
Ferroptosis, an iron-dependent form of cell death involving lipid peroxidation, is considered a key mechanism in the development of postoperative cognitive dysfunction (POCD) in older patients.
Full answer →Does spontaneous-breathing anesthesia protect elderly patients from postoperative cognitive dysfunction?
Spontaneous-breathing anesthesia may offer cognitive protection to elderly patients by improving oxygen balance and reducing inflammation compared to traditional intubation methods.
Full answer →