Remimazolam may reduce early postoperative cognitive dysfunction risk and intraoperative opioid consumption in elderly patients
Remimazolam May Reduce Early Cognitive Risks After Surgery
This meta-analysis of 2,226 elderly surgical patients evaluated remimazolam compared to other sedatives. The analysis found that remimazolam…
A new sedative may help protect elderly patients from early cognitive issues after surgery while reducing the need for other pain medication…
Dexmedetomidine plus esketamine may reduce postoperative delirium and injury
Combined dexmedetomidine and esketamine may protect brain function after surgery
Perioperative combo of dexmedetomidine and esketamine lowers neuronal injury biomarkers and delirium risk in surgical patients.
A new analysis suggests a combination of two medications could lower the risk of confusion and protect brain health during and after surgery…
Gastrodin, intranasal insulin, and cognitive training show greatest preventive effectiveness for postoperative cognitive dysfunction after cardiac surgery
Insulin, Gastrodin, and Training May Protect Brain After Heart Surgery
A systematic review and Bayesian network meta-analysis of 46 RCTs (9,928 patients) ranked 20 strategies for preventing postoperative cogniti…
A review of 46 trials suggests certain drugs and cognitive training may help prevent confusion and memory loss after cardiac surgery.
Shenmai and Shenfu injections may reduce postoperative cognitive dysfunction incidence following surgical procedures
Two injections may help patients recover mental clarity after surgery
This meta-analysis of 16 RCTs involving 1,199 patients indicates that Shenmai and Shenfu injections are associated with higher MMSE scores a…
New data suggests that Shenmai and Shenfu injections could help patients regain mental clarity and awareness more quickly after undergoing s…
Review of ferroptosis role in postoperative cognitive dysfunction in older surgical patients
Aging and surgery may trigger brain cell death in older patients
This narrative review examines the potential role of ferroptosis in postoperative cognitive dysfunction among older surgical patients. The a…
A review suggests aging and surgery might trigger brain cell death in older patients, but scientists are not sure if this process causes the…
Bibliometric review of anesthesia-associated postoperative cognitive dysfunction in elderly patients from 2000 to 2024
Why Your Brain Fog After Surgery Might Start in Your Gut
This bibliometric review analyzed 923 publications indexed in the Web of Science Core Collection and PubMed database regarding anesthesia-as…
Understanding how surgery and anesthesia trigger brain inflammation could lead to new ways to prevent memory loss after operations.
Narrative review suggests spontaneous-breathing anesthesia may offer cognitive protection in elderly surgical patients
Breathing Naturally Might Protect Elderly Brains
A narrative review of existing clinical evidence suggests spontaneous-breathing anesthesia may have cognitive protective effects compared to…
Letting older patients breathe naturally during surgery could help keep their minds sharp by reducing brain stress and inflammation.
PENG block with bupivacaine reduces early POCD incidence after hip arthroplasty in older patients
PENG block may lower confusion and pain after hip surgery in older adults
In a randomized, double-blind study of 84 older patients undergoing hip arthroplasty, ultrasound-guided PENG block with 0.25% bupivacaine re…
An ultrasound-guided PENG block lowers confusion and pain after hip surgery in older adults, helping them move earlier and use fewer painkil…
Research across Cognitive Dysfunction
Related studies from across the Cognitive Dysfunction family.
Gut microbiome dysbiosis may contribute to cognitive decline through neuroinflammation and hypertension-mediated cerebrovascular injury
Gut health and blood pressure may impact brain health
This narrative review explores the gut-brain-vascular axis, proposing that gut microbiome dysbiosis contributes to cognitive decline via neu…
New research explores how an unbalanced gut and high blood pressure might work together to cause brain aging and cognitive decline.
Luteolin monotherapy improves cognitive and memory impairments in rodent models of Alzheimer disease
Luteolin may improve memory and brain health in rodent models
This meta-analysis of preclinical rodent models indicates that luteolin monotherapy significantly ameliorates cognitive and memory impairmen…
A review of research suggests the compound luteolin could protect memory and reduce brain inflammation in models of Alzheimer's disease.
Electroacupuncture provides short-term improvements in MoCA and MMSE scores for MCI and early Alzheimer's
Electroacupuncture shows short term improvements for early Alzheimer's symptoms
This meta-analysis of 614 patients with Mild Cognitive Impairment and early Alzheimer's Disease found that electroacupuncture led to short-t…
Electroacupuncture may improve cognitive scores and reduce inflammation markers in people with early Alzheimer's and mild cognitive impairme…
Mind-body exercise improves global cognition and processing speed in older adults with mild cognitive impairment
Mind Body Exercise May Improve Cognition in Older Adults
This meta-analysis of 2034 older adults with mild cognitive impairment found that mind-body exercise significantly improves global cognition…
Mind body exercises may improve memory and processing speed for older adults with mild cognitive impairment, according to a large meta-analy…
Resistance training shows largest effect for global cognition in Alzheimer's and Parkinson's disease
Resistance training shows strongest results for cognitive health in dementia
This network meta-analysis of 1,993 participants evaluated six exercise modalities for global cognitive function in Alzheimer's disease, Par…
Resistance training may offer the strongest boost to cognitive function for people living with Alzheimer's or Parkinson's disease.
Scoping review protocol to map living arrangement and carer variables in dementia help-seeking research
Mapping How Living Arrangements Affect Help Seeking for Dementia
This is a scoping review protocol, not a completed study, that will map how living arrangement and supporter or carer related variables are …
New research plans to map how living situations and family support impact how people with memory problems seek a diagnosis for dementia.
Elevated plasma CD147 levels are associated with 1.75 odds ratio for poststroke cognitive impairment
Higher CD147 levels linked to cognitive issues after stroke
This observational study of 612 patients with ischemic stroke found that elevated plasma CD147 levels were associated with a 1.75 odds ratio…
A new look at stroke recovery shows that higher levels of a specific protein in the blood may signal a higher risk of lasting brain fog.
Non-pharmacological interventions for sleep disturbances in mild cognitive impairment and early dementia provide management guidance
Sleep Care Plan for Early Dementia: Best Evidence
This integrative review and guideline identifies 44 evidence items across 11 themes for managing sleep disturbances in patients with mild co…
A new review maps 44 best evidence items for managing sleep problems in mild cognitive impairment and early dementia.
Higher adherence to MedDiet and DASH associated with better executive function in aging populations
Mediterranean and DASH diets linked to better brain health
This meta-analysis of 8 longitudinal cohorts involving 17,368 individuals in Europe and the United States found that higher adherence to the…
Specific dietary patterns like the Mediterranean and DASH diets may help protect memory and mental focus as people age.
Combined physical and cognitive interventions improve global cognitive function and gait speed in frail older adults
Combined physical and cognitive exercise helps frail older adults
This meta-analysis of randomized controlled trials involving 989 participants found that combined physical and cognitive interventions signi…
A combined program of physical and cognitive exercises can improve memory and mobility for frail older adults while reducing signs of frailt…
Dysregulated tryptophan metabolism drives neurocognitive complications in approximately 40% of patients with chronic kidney disease
Tryptophan metabolism may link kidney disease to brain fog
This narrative review explores how dysregulated tryptophan metabolism, including kynurenine and indole pathways, contributes to cognitive im…
About 40% of people with chronic kidney disease experience cognitive issues, potentially linked to how the body processes a nutrient called …
Aerobic and combined physical-cognitive training programs may improve executive function and decision-making in older adults
Combined Physical and Cognitive Training May Improve Decision Making
This narrative review examines the impact of aerobic and combined physical-cognitive training on cognitive decline in healthy older adults. …
Combining aerobic exercise with cognitive training may improve executive functions and brain health in older adults to support better decisi…
Questions about Postoperative cognitive dysfunction
Does using bupivacaine during hip replacement lower the risk of postoperative cognitive dysfunction?
Yes, a 2026 study found that a bupivacaine nerve block (PENG block) before hip replacement reduced POCD risk at 7 days (14.6% vs 37.2%).
Full answer →Is there a link between ferroptosis and postoperative cognitive dysfunction in older patients?
Ferroptosis, an iron-dependent form of cell death involving lipid peroxidation, is considered a key mechanism in the development of postoperative cognitive dysfunction (POCD) in older patients.
Full answer →Does spontaneous-breathing anesthesia protect elderly patients from postoperative cognitive dysfunction?
Spontaneous-breathing anesthesia may offer cognitive protection to elderly patients by improving oxygen balance and reducing inflammation compared to traditional intubation methods.
Full answer →