N/A
Completed N=73
Peritoneal Dialysis vs Furosemide for Acute Kidney Injury After Cardiopulmonary Bypass
Source: ClinicalTrials.gov NCT01709227 ↗Enrolled (actual)
73
Serious AEs
0.0%
Results posted
Jun 2017
Primary outcomePrimary: Number of Participants With Negative Fluid Balance on Postop Day 1 — 21; 29 Participants
Summary
Acute kidney injury (AKI) after cardiopulmonary bypass (CPB) in infants is common and associated with poor outcomes. Peritoneal dialysis (PD) and furosemide have been used to attain negative fluid balance due to AKI induced oliguria, but have not been compared prospectively. The investigators will prospectively compare outcomes of infants with oliguria after CPB randomized to PD vs. furosemide with the hypothesis that infants receiving PD have superior outcomes.
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Number of Participants With Negative Fluid Balance on Postop Day 1 |
21; 29 | — |
| SECONDARY Respiratory Support Administered |
4; 3 | — |
| SECONDARY NGAL Concentration |
— | — |
| SECONDARY Duration of Cardiac ICU Stay |
9; 7 | — |
| SECONDARY Duration of Hospital Stay |
15; 14 | — |
| SECONDARY All Cause Mortality |
3; 1 | — |
| SECONDARY Renal/Electrolyte Abnormalities |
6; 4 | — |
| SECONDARY Doses of Potassium Chloride or Arginine Chloride Required |
2; 1 | — |
| SECONDARY B-Natriuretic Peptide |
1334; 1168; 1110; 663 | — |
| SECONDARY Modified Oxygenation Index |
4; 4; 3.8; 2.8 | — |
Eligibility Criteria
Inclusion Criteria
- Age less than 6 months of age;
- Undergoing cardiothoracic surgery with CPB;
- Planned placement of PD catheter per institutional standard of care criteria.
Exclusion Criteria
- Pre-existing chronic kidney disease stage 3 or above (correlating with estimated GFR<60 ml/min/m2, which will be calculated using routine preoperative serum creatinine value using the modified Schwartz equation).
- Known history of allergy to furosemide.
Data sourced from ClinicalTrials.gov (NCT01709227). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication. Informational only — not medical advice.