N/A
N=38
Using Transcranial Direct Current Stimulation (tDCS) to Improve Post-Stroke Aphasia
Aphasia
Bottom Line
View on ClinicalTrials.gov: NCT01709383 ↗Enrolled (actual)
38
Serious AEs
0.0%
Results posted
Jul 2017
Primary outcome: Primary: Western Aphasia Battery - Revised: Naming and Word Finding Score — .30; .48 scores on a scale — p=.57
Study Design & Population
- Study type
- Interventional
- Phase
- N/A
- Interventions
- Transcranial Direct Current Stimulation (Device); Sham Stimulation (Device)
- Age
- Adult, Older Adult · 18+ yrs
- Sex
- All
- Sponsor
- Georgetown University
- Primary completion
- Jul 2015
Outcome Measures
| Outcome | Result | p-value |
|---|---|---|
| PRIMARY Western Aphasia Battery - Revised: Naming and Word Finding Score |
.30; .48 | .57 |
| SECONDARY Western Aphasia Battery - Revised: Spontaneous Speech, Repetition, Auditory Verbal Comprehension and Overall Aphasia Quotient |
7.6; 7.1; 7.8; 7.0; 5.5; 6.2 | — |
| SECONDARY Philadelphia Naming Test (PNT) |
31.3; 32.1; 34.1; 34.9 | .64 |
| SECONDARY Subjective Assessments Including: Communicative Effectiveness Index (CETI), Stroke and Aphasia Quality of Life Scale (SAQOL), and Stroke Aphasic Depression Questionnaire (SADQ) |
1.2; 1.58; 1.0; 1.3; 2.7; 2.6 | — |
| SECONDARY Cognitive-Linguistic Quick Test (CLQT) |
150.0; 175.5; 155.9; 184.9; 21.9; 23.7 | — |
| SECONDARY Reading Assessments |
89.1; 85.1; 89.7; 87.3; 6.1; 8.9 | — |
| SECONDARY Motricity Index |
33; 33; 33; 33; 33; 33 | — |
Summary
This study tests whether weak electrical stimulation of the brain is effective in improving language or reading difficulties occurring after a brain injury or stroke.
Eligibility Criteria
Inclusion Criteria
- Age 18 or older
- Aphasia due to left hemisphere stroke diagnosed by a physician or speech-language pathologist
Exclusion Criteria
- Skull defect at or near the site of tDCS delivery
- History of a significant stroke or traumatic brain injury other than the event that caused the aphasia
- History of other brain conditions that could impact interpretation of results (such as multiple sclerosis, brain tumor, encephalitis, premorbid dementia)
- Presence of implanted electrical or metallic devices in the head or body (except titanium; e.g. cochlear implants, implanted shunts with metal parts, deep brain stimulators, pacemakers, defibrillators)
- Presence of ferrous metal in the head (e.g. shrapnel)
- History of psychiatric disease requiring hospitalization, electroconvulsive therapy, or ongoing medication use (other than common selective serotonin reuptake inhibitor antidepressants)
- Pregnancy
- Severe comprehension deficits
Additional Exclusion Criteria for the optional MRI portion of the study:
- Presence of metal in the body (except titanium)
- Claustrophobia
Data sourced from ClinicalTrials.gov (NCT01709383). Outcome figures and adverse-event rates are extracted automatically from the registry's posted results and are provided for clinician reference, not as a substitute for the primary publication.